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Anti-infective therapy of peri-implant mucositis with adjunctive delivery of a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical trial

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Abstract

Objective

To evaluate the effects of adjunctive delivery of a sodium hypochlorite gel in the treatment of peri-implant mucositis (PM).

Materials and methods

Forty-six subjects with 68 implants diagnosed with PM were randomly assigned to two treatment groups. Prior to mechanical debridement, a sodium hypochlorite gel was delivered to the implants of the test group while implants of the control group received a placebo gel. Application of both test and placebo gels was repeated 5 times at baseline. The primary outcome variable was the change in pocket probing depth (PPD) between baseline and 6 months.

Results

After 6 months, the mean PPD decreased statistically significantly from 3.93 ± 1.09 mm to 3.04 ± 0.46 mm in the test (p = 0.0001) and from 3.68 ± 0.85 mm to 3.07 ± 0.58 mm in the control (p = 0.0001) group, respectively. No statistically significant difference (p = 0.53) was observed with respect to PPD changes from baseline to 6 months between test (0.88 ± 1.04 mm) and control group (0.61 ± 0.75 mm), respectively. The number of implants with bleeding on probing (BoP) decreased statistically significantly from 33 to 18 in the test group (p = 0.0001) and from 34 to 23 in the control group (p = 0.0001) after 6 months.

Conclusions

In conclusion and within the limits of the present study, changes in PPD from baseline to 6 months were not statistically significantly different between groups. Complete resolution of mucosal inflammation was not achieved with either of the therapies.

Clinical relevance

The present outcomes have showed that a complete resolution of peri-implant mucositis is not possible to obtain by means mechanical debridement with or without a sodium hypochlorite gel application.

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Acknowledgments

The experimental materials used in the present study were provided by Regedent AG, Zürich, Switzerland.

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Authors and Affiliations

  1. Department of Periodontology, University of Naples Federico II, Via S Pansini 5, Piata, 80131, Naples, Italy

    Vincenzo Iorio-Siciliano, Andrea Blasi & Luca Ramaglia

  2. Department of Health Sciences, School of Dental Medicine, University of Catanzaro, Viale Europa Località Germaneto, 88100, Catanzaro, Italy

    Vincenzo Iorio-Siciliano

  3. Department of Periodontology, Victor Babes University, Piata Eftimie 2, 300041, Timisoara, Romania

    Stefan-Ioan Stratul & Darian Rusu

  4. Department of Periodontology, School of Dental Medicine, University of Bern, Freiburgstrasse, 7CH-3010, Bern, Switzerland

    Anton Sculean & Giovanni E. Salvi

Authors
  1. Vincenzo Iorio-Siciliano
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  2. Andrea Blasi
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  3. Stefan-Ioan Stratul
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  6. Giovanni E. Salvi
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Correspondence to Vincenzo Iorio-Siciliano.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Iorio-Siciliano, V., Blasi, A., Stratul, SI. et al. Anti-infective therapy of peri-implant mucositis with adjunctive delivery of a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical trial. Clin Oral Invest 24, 1971–1979 (2020). https://doi.org/10.1007/s00784-019-03060-2

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