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Root-end surgery with leucocyte- and platelet-rich fibrin and an occlusive membrane: a randomized controlled clinical trial on patients’ quality of life

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Abstract

Objectives

The aim of this study was to investigate the impact of the adjunct of leukocyte- and platelet-rich fibrin (LPRF) to root-end surgery (RES) on the patients’ quality of life during the first week post RES.

Materials and methods

Patients in need of RES were recruited for an open randomized controlled clinical trial (RCT) with a 2 × 2 factorial design. They were randomly allocated to the test (+LPRF) and control (−LPRF) group. Each group was subsequently divided into two strata: with or without an occlusive membrane (Bio-Gide®, Geistlich Biomaterials, Switzerland; BG). After RES, the patients completed daily for 1 week a visual analog pain scale (VAS) and a 5-point Likert-type scale questionnaire concerning activity impairment, occurrence of symptoms, and medication use.

Results

Fifty patients were included, equally divided between the test and control group. Only one patient in the “−LPRF+BG-group” had to take additional antibiotics due to a persistent jaw swelling. There was no evidence (p ≤ 0.05) for a difference between the test and control group in VAS, occurrence of pain symptoms, impairment of daily activities, and medication use, over the 7 days and daily during the 7 days post RES.

Conclusions

There was no statistical significant evidence for improvement of patients’ quality of life during the first week post RES with LPRF in comparison with RES without LPRF.

Clinical relevance

Although LPRF seems to be an inexpensive and autologous agent to reduce pain and swelling post RES, this RCT does not provide a statistical significant evidence for that.

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Authors and Affiliations

  1. Department of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a- box 7001, 3000 Leuven, Belgium

    Nastaran Meschi, Olaf Strijbos, Dominique Van der Veken & Paul Lambrechts

  2. Biomaterialen—BIOMAT, KU Leuven, Kapucijnenvoer 7 blok a- box 7001, 3000, Leuven, Belgium

    Nastaran Meschi, Olaf Strijbos, Dominique Van der Veken & Paul Lambrechts

  3. Leuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, University of Leuven, Kapucijnenvoer 35 blok d - box 7001, 3000, Leuven, Belgium

    Steffen Fieuws

  4. Stomatology and Maxillofacial Surgery, KU Leuven & Dentistry, University Hospitals Leuven, Kapucijnenvoer 7 blok a - box 7001, 3000, Leuven, Belgium

    Anke Vanhoenacker & Constantinus Politis

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  1. Nastaran Meschi
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  2. Steffen Fieuws
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  3. Anke Vanhoenacker
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  7. Paul Lambrechts
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Corresponding author

Correspondence to Nastaran Meschi.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Ethical approval was obtained from the Medical Ethics Committee UZ KU Leuven (KU Leuven, Leuven, Belgium; registration number: S58015/B322201525314).

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Meschi, N., Fieuws, S., Vanhoenacker, A. et al. Root-end surgery with leucocyte- and platelet-rich fibrin and an occlusive membrane: a randomized controlled clinical trial on patients’ quality of life. Clin Oral Invest 22, 2401–2411 (2018). https://doi.org/10.1007/s00784-018-2343-z

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  • DOI: https://doi.org/10.1007/s00784-018-2343-z

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