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Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis

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Abstract

Objectives

Candida albicans is a common fungal infection and is commensal in 40–65 % of healthy adults. The development and pharmacokinetics of a novel sustained release clotrimazole varnish (Clot-SRV) for topical oral use have been reported. The aim of this study was to compare the efficacy of this varnish with clotrimazole troche treatment of oral candidiasis.

Materials and methods

Of the 12 patients with denture stomatitis treated for 14 days, six used Clot-SRV (study group) and six clotrimazole troches (control). The patients were instructed to use Clot-SRV (50 mg of clotrimazole) once a day, and the control group was instructed to use five troches of 10 mg clotrimazole/day. Microbiological samples were obtained from saliva, buccal mucosa, palate, and denture. The degree of erythema was recorded at three time points, and subjective opinions noted using a questionnaire.

Results

At the end of the study, the control group had relatively more cases of erythema on all examined surfaces; patients who applied the Clot-SRV had significantly lower levels of candida on the denture surfaces and in saliva, and had better compliance to the medication.

Conclusions

The novel clotrimazole sustained release varnish may be an important part of a new protocol for oral candidiasis, with improved clinical outcomes.

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Acknowledgments

This study was partially supported by the P&G Innovation Award.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Oral Medicine, School of Dental Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel

    Rakefet Czerninski & Anna Pikovsky

  2. Institute for Drug Research, School of Pharmacy, Hebrew University-Hadassah Medical Center, Jerusalem, Israel

    Irith Gati & Michael Friedman

  3. Institute of Dental Sciences, Faculty of Dental Medicine, Hebrew University-Hadassah, Jerusalem, Israel

    Doron Steinberg

Authors
  1. Rakefet Czerninski
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  2. Anna Pikovsky
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  3. Irith Gati
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  4. Michael Friedman
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  5. Doron Steinberg
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Corresponding author

Correspondence to Rakefet Czerninski.

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Czerninski, R., Pikovsky, A., Gati, I. et al. Comparison of the efficacy of a novel sustained release clotrimazole varnish and clotrimazole troches for the treatment of oral candidiasis. Clin Oral Invest 19, 467–473 (2015). https://doi.org/10.1007/s00784-014-1259-5

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  • DOI: https://doi.org/10.1007/s00784-014-1259-5

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