Abstract
Introduction
Surgery is the standard treatment for medication-related osteonecrosis of the jaw (MRONJ). This study reviewed patients with mandibular MRONJ who underwent surgical treatment, and in particular the characteristics of non-osteolytic MRONJ with no evidence of osteolysis on CT were described.
Materials and methods
We conducted a retrospective study of patients with mandibular MRONJ who underwent surgery between January 2016 and September 2022. Various clinical and imaging factors regarding treatment outcomes were investigated and analyzed. Additionally, the disease course of non-osteolytic MRONJ was examined in detail.
Results
This study included 55 patients (66 surgeries) with a mean age of 74.7. The primary disease was osteoporosis (24 patients) and malignancy (31 patients); the type of antiresorptive agent was bisphosphonate (BP) in 21 patients and denosumab (DMB) in 26. BP was initially administered; however, it was changed to DMB in eight patients. Preoperatively, the cumulative cure rates for all 66 surgeries were 72.8% at 1 year and 77.3% at 2 years. Cure rates were significantly lower in patients with malignancy, those without osteolysis, and those who underwent sequestrum removal or marginal mandibulectomy than those with osteoporosis, osteolysis, and segmental mandibulectomy. Non-osteolytic MRONJ was observed in eight patients, all with malignancy and receiving high-dose DMB. Only two patients were cured after the initial surgery, and most patients ultimately underwent segmental mandibulectomy.
Conclusions
Surgical treatment yielded good treatment outcomes in most patients with mandibular MRONJ; however, the cure rate was lower in patients with malignancy who showed no osteolysis on CT images.
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Data availability
The datasets used and analyzed in the current study are available from the corresponding author upon reasonable request.
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We thank Editage (www.editage.jp) for their English language editing services.
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Study design: YK. Study conduct: YK. Data collection: YK, SS and YS. Data analysis: YK. YK, SS and YS interpreted the data. YK. drafted the manuscript. Revision of the manuscript content: SS and YS. Approval of the final version of the manuscript: YK, SS and YS. YK takes responsibility for the integrity of data analysis.
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Kojima, Y., Sawada, S. & Sakamoto, Y. Medication-related osteonecrosis of the lower jaw without osteolysis on computed tomography images. J Bone Miner Metab 42, 27–36 (2024). https://doi.org/10.1007/s00774-023-01484-1
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DOI: https://doi.org/10.1007/s00774-023-01484-1