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Association of alcohol and bone mineral density dependent on type of alcohol consumed

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Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Introduction

Osteoporosis prevalence will increase in coming decades, with significant financial and economic implications. Whilst alcohol excess has significant detrimental impacts on bone mineral density (BMD), knowledge of low-volume consumption is inconsistent. Type of alcohol may mediate impact on BMD and warrants further investigation.

Materials and methods

Participants were drawn from the Florey Adelaide Male Aging Study, a cohort of community dwelling men from Adelaide, Australia (n = 1195). The final cohort (n = 693) provided information regarding alcohol consumption and undertook BMD scan at wave one (2002–2005) and wave two (2007–2010). Cross-sectional and longitudinal multivariable regression was performed for whole-body and spine BMD. To assess change in exposure over time, change in BMD was compared to change in covariates between waves.

Results

Cross-sectionally, whole-body BMD was positively associated with obesity (p < 0.001), exercise (p = 0.009), prior smoking (p = 0.001), oestrogen concentration (p = 0.001), rheumatoid arthritis (p = 0.013) and grip strength (p < 0.001). No association was identified with volume of differing types of alcohol consumed. Spinal BMD was inversely associated with low-strength beer consumption (p = 0.003). The volume of alcohol consumed at Wave 1 did not predict change in whole-body or spinal BMD; however, increases in full-strength beer consumption between waves were associated with reduced spinal BMD (p = 0.031).

Conclusion

When consumed at quantities in the usual social range, alcohol was not associated with whole-body BMD. However, low-strength beer consumption was inversely related to spinal BMD.

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Authors and Affiliations

  1. Freemasons Foundation Centre for Men’s Health, South Australia Health Medical Research Institute and University of Adelaide, Level 6 University of Adelaide Medical School, North Terrace, Adelaide, 5000, Australia

    Andrew Peel & Gary Wittert

  2. Queen Elizabeth Hospital, Woodville, South Australia, Australia

    David Jesudason

  3. Australian Institute of Family Studies, Melbourne, Australia

    Sean Martin

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Article was written by AP, review and editing was performed by GW, DJ and SM. All authors approved the final copy of the article.

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Correspondence to Andrew Peel.

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Peel, A., Jesudason, D., Martin, S. et al. Association of alcohol and bone mineral density dependent on type of alcohol consumed. J Bone Miner Metab 41, 702–713 (2023). https://doi.org/10.1007/s00774-023-01450-x

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  • DOI: https://doi.org/10.1007/s00774-023-01450-x

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