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Predictors of bone mineral density in adolescents with atypical anorexia nervosa

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Abstract

Introduction

We aimed to evaluate the bone mineral density (BMD) z scores of adolescents with atypical anorexia nervosa (AAN) and investigate the potential predictors of low BMD risk.

Materials and methods

Potential factors that might have an effect on the femoral neck and lumbar spine dual energy X-ray absorptiometry data of adolescents (11–18 years) with AAN were retrospectively evaluated.

Results

Among adolescents with AAN, 13 (34.2%) had a z score lower than − 1 and 25 (65.8%) had a z score equal or greater than − 1. When adolescents with a BMD score lower and higher than − 1 were compared, normal BMD group had a significantly higher mean lifetime maximum BMI (p = 0.0035). Similarly previous overweight history was significantly higher in the normal BMD group (p = 0.005). A positive correlation was found between femoral neck (p = 0.002, r: 0.546) and lumbar spine (p: 0.002, r: 0.505) z scores and lifetime maximum BMI. There was also a positive correlation between lumbar spine BMD scores and BMI at admission (p = 0.001, r: 0.540). Lumbar spine z scores and amenorrhea duration were negatively correlated (p: 0.002, r:  − 10.867).

Conclusion

In the adolescent period similar to AN, AAN cases are also at risk for disordered bone health. In adolescents with AAN, BMI prior to the illness was estimated to be the significant parameter for the risk of low BMD. Special attention should be paid to the bone health of adolescents with AAN, especially for those who do not have a previous overweight history.

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Funding

No funding was secured for this study.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Adolescent Medicine, Hacettepe University Ihsan Dogramaci Children’s Hospital, Ankara, Turkey

    Melis Pehlivanturk-Kizilkan, Sinem Akgul, Orhan Derman & Nuray Kanbur

Authors
  1. Melis Pehlivanturk-Kizilkan
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  2. Sinem Akgul
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  3. Orhan Derman
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  4. Nuray Kanbur
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Contributions

All authors contributed to the study conception and design. MP-K performed data collection and statistical analysis. The first draft of the manuscript was written by MP-K and all the other authors commented on the previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Melis Pehlivanturk-Kizilkan.

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Conflict of interest

The authors have no financial relationships relevant to this article to disclose. The authors have no conflicts of interest to disclose.

Ethical approval

This study was approved by the Clinical Research Ethics Board of Hacettepe University (GO 19/837).

Informed consent

Informed consent was obtained from all individual participants and their parents included in the study. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Pehlivanturk-Kizilkan, M., Akgul, S., Derman, O. et al. Predictors of bone mineral density in adolescents with atypical anorexia nervosa. J Bone Miner Metab 39, 678–683 (2021). https://doi.org/10.1007/s00774-021-01211-8

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  • DOI: https://doi.org/10.1007/s00774-021-01211-8

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