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Assessment of patient-reported outcomes (PROs): treatment satisfaction, medication adherence, and quality of life (QoL) and the associated factors in postmenopausal osteoporosis (PMO) patients in Korea

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Abstract

Patient-reported outcomes (PROs) provide practical guides for treatment; however, studies that have evaluated PROs of women in Korea with postmenopausal osteoporosis (PMO) are lacking. This cross-sectional, multi-center (29 nationwide hospitals) study, performed from March 2013 to July 2014, aimed to assess PROs related to treatment satisfaction, medication adherence, and quality of life (QoL) in Korean PMO women using osteoporosis medication for prevention/treatment. Patient demographics, clinical characteristics, treatment patterns, PROs, and experience using medication were collected. The 14-item Treatment Satisfaction Questionnaire for Medication (TSQM) (score-range, 0–100; domains: effectiveness, side effects, convenience, global satisfaction), Osteoporosis-Specific Morisky Medication Adherence Scale (OS-MMAS) (score-range, 0–8), and EuroQol-5 dimensions questionnaire (index score range, − 0.22 to 1.0; EuroQol visual analog scale score range, 0–100) were used. To investigate factors associated with PROs, linear (treatment satisfaction/QoL) or logistic (medication adherence) regression analyses were conducted. A total of 1804 patients (age, 62 years) were investigated; 60.1% used bisphosphonate, with the majority (67.2%) using weekly medication, 27.8% used daily hormone replacement therapy, and 12.1% used daily selective estrogen receptor modulator. Several patients reported gastrointestinal (GI) events (31.6%) and dental visits due to problems (24.1%) while using medication. Factors associated with the highest OS-MMAS domain scores were convenience and global satisfaction. GI events were associated with non-adherence. TSQM scores for effectiveness, side effects, and GI risk factors were significantly associated with QoL. Our study elaborately assessed the factors associated with PROs of Korean PMO women. Based on our findings, appropriate treatment-related adjustments such as frequency/choice of medications and GI risk management may improve PROs.

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Acknowledgements

This research was sponsored by Pfizer.

Author information

Authors and Affiliations

  1. Department of Endocrinology, Internal Medicine, Soon Chun Hyang University Hospital, Seoul, South Korea

    Dong Won Byun

  2. Department of Orthopedic Surgery, Severance Hospital, Yonsei University Health System, Seoul, South Korea

    Seong-Hwan Moon

  3. Department of Obstetrics and Gynecology, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea

    Tak Kim

  4. Department of Obstetrics and Gynecology, Soonchunhyang University Bucheon Hospital, Bucheon, South Korea

    Hae-Hyeog Lee

  5. Department of Obstetrics and Gynecology, Chung-Ang University Hospital, Seoul, South Korea

    Hyoung Moo Park

  6. Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary’s Hospital, Seoul, South Korea

    Moo-Il Kang

  7. Department of Orthopedic Surgery, Chung-Ang University Hospital, Seoul, South Korea

    Yong-Chan Ha

  8. Department of Endocrinology and Metabolism, Kyung Hee University, School of Medicine, Seoul, South Korea

    Ho-Yeon Chung

  9. Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University, Seoul, South Korea

    Byung-Koo Yoon

  10. Department of Orthopedic Surgery, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, South Korea

    Tae-Young Kim

  11. Department of Orthopedic Surgery, Gunsan Medical Center of Wonkwang University Hospital, Gunsan, South Korea

    Soo Uk Chae

  12. Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea

    Chan Soo Shin

  13. Department of Orthopedic Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea

    Kyu-Hyun Yang

  14. Department of Orthopedic Surgery, Seoul National University College of Medicine, SMG-SNU Boramae Medical Center, Seoul, South Korea

    Jae Hyup Lee

  15. Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Jae Suk Chang

  16. Department of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Sung Hoon Kim

  17. Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Busan, South Korea

    In Joo Kim

  18. Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea

    Jung-Min Koh

  19. Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, South Korea

    Jung Hwa Jung

  20. Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, South Korea

    Kyong Wook Yi

  21. Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea

    Jeong Joon Yoo

  22. Department of Internal Medicine, Chonnam National University Medical School, Gwangju, South Korea

    Dong Jin Chung

  23. Department of Orthopedic Surgery, Seoul National University Bundang Hospital, Seongnam, South Korea

    Young-Kyun Lee

  24. Division of Endocrinology and Metabolism, Department of Medicine, Cheil General Hospital and Women’s Healthcare Center, Dankook University, Seoul, South Korea

    Hyun-Koo Yoon

  25. Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, South Korea

    Seongbin Hong

  26. Department of Nuclear Medicine, Kyung Hee University, School of Medicine, Seoul, South Korea

    Deog-Yoon Kim

  27. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Ki Hyun Baek

  28. Pfizer Pharmaceuticals Korea Limited, Seoul, Republic of Korea

    Hyun-Joo Kim, Young-Joo Kim & Seongsik Kang

  29. Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

    Yong-Ki Min

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  1. Dong Won Byun
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  2. Seong-Hwan Moon
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  3. Tak Kim
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  29. Young-Joo Kim
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  30. Seongsik Kang
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  31. Yong-Ki Min
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Correspondence to Yong-Ki Min.

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Informed consent was obtained from all individual participants included in the study.

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Byun, D.W., Moon, SH., Kim, T. et al. Assessment of patient-reported outcomes (PROs): treatment satisfaction, medication adherence, and quality of life (QoL) and the associated factors in postmenopausal osteoporosis (PMO) patients in Korea. J Bone Miner Metab 37, 563–572 (2019). https://doi.org/10.1007/s00774-018-0956-6

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