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Predicting bone mineral acquisition during puberty: data from a 3-year follow-up study in Hamamatsu, Japan

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Abstract

Although most adult bone mass is acquired before adolescence, only a few studies have assessed bone turnover markers in children. Thus, the utility of bone markers to evaluate and predict bone mineral accrual in children is unclear. The present study assessed the association between serum bone markers at 11 years of age and subsequent changes in bone gain. Information on bone minerals and bone markers at baseline and at the 3-year follow-up were obtained from 121 children who registered as fifth-grade students in 2010, in Hamamatsu, Japan. Whole-body bone mineral content (WBBMC) and whole-body bone mineral density (WBBMD) were measured using dual-energy X-ray absorptiometry. Boys showed significant (P < 0.05) positive relationships between intact osteocalcin at baseline and WBBMC at follow-up (β = 0.24), between tartrate-resistant acid phosphatase isoenzyme 5b (TRAP5b) and WBBMC (β = 0.34), and between TRAP5b and WBBMD (β = 0.34), after adjusting for potential confounding factors. In girls, adjusted means of 3-year gain in both WBBMC and WBBMD significantly increased from the lowest to highest quartiles of type 1 collagen cross-linked C-terminal telopeptide. In boys, adjusted means of 3-year gain in both WBBMC and WBBMD significantly increased from the lowest to highest quartiles of TRAP5b. Children with a high concentration of bone turnover markers tended to exhibit substantial accrual of bone minerals. These results suggest that serum levels of circulating biomarkers at age 11 predict subsequent bone mineral accrual.

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Acknowledgments

The authors thank the teaching staff at Aritama Elementary School and Sekishi Elementary School and Dr. Toshiko Okamoto for their support. This work was supported by Grants-in-Aid for Scientific Research (KAKENHI Grant Numbers 21657068, 22370092, 24370101, 26291100) from the Japan Society for the Promotion of Science.

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Authors and Affiliations

  1. Department of Public Health, Kinki University Faculty of Medicine, 377-2 Oono-higashi, Osaka-Sayama, 589-8511, Japan

    Katsuyasu Kouda, Yuki Fujita & Masayuki Iki

  2. Department of Health Promotion and Education, Graduate School of Human Development and Environment, Kobe University, 3-11 Tsurukabuto, Nada, Kobe, 657-8501, Japan

    Kumiko Ohara & Harunobu Nakamura

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  1. Katsuyasu Kouda
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  2. Kumiko Ohara
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  3. Harunobu Nakamura
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  4. Yuki Fujita
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  5. Masayuki Iki
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Correspondence to Katsuyasu Kouda.

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Kouda, K., Ohara, K., Nakamura, H. et al. Predicting bone mineral acquisition during puberty: data from a 3-year follow-up study in Hamamatsu, Japan. J Bone Miner Metab 35, 185–191 (2017). https://doi.org/10.1007/s00774-016-0740-4

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  • DOI: https://doi.org/10.1007/s00774-016-0740-4

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