Skip to main content

Advertisement

SpringerLink
Log in

Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women

  • Original Article
  • Published:
Journal of Bone and Mineral Metabolism Aims and scope Submit manuscript

Abstract

Despite experimental and animal evidence showing the detrimental effects of platelet-activating factor (PAF) on bone metabolism, there are no clinical studies relating PAF to osteoporosis-related phenotypes. This case–control study investigates the association between plasma PAF, osteoporotic vertebral fracture (VF), and bone mineral density (BMD) in postmenopausal Korean women. Among 474 eligible women not taking any drug or having any disease that could affect bone metabolism, we identified 73 cases defined as subjects with radiological VF. The controls were randomly selected from the remaining 401 subjects and matched 1:1 to cases in terms of both age and body mass index (BMI). Lateral thoracolumbar radiographs, BMD, and plasma PAF levels were determined for all subjects. Postmenopausal women with VF demonstrated 34.6 % higher plasma PAF levels than subjects without VF after adjusting for age, BMI, smoking habits, alcohol intake, regular exercise, and parental history of osteoporotic fractures (P = 0.021). Multiple logistic regression analyses revealed that the odds ratio for VF linearly increased across increasing PAF quartiles (P for trend = 0.040) and the odds for VF were 2.88-fold higher in subjects in the highest quartile in comparison with those in the lowest quartile (95 % CI 1.04–8.01). Plasma PAF levels were inversely correlated with BMD at various sites (γ = −0.253 to −0.176, P = 0.003–0.041). These findings suggest that plasma PAF may be a potential biomarker for predicting poor bone health in postmenopausal women.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hattner R, Epker BN, Frost HM (1965) Suggested sequential mode of control of changes in cell behaviour in adult bone remodelling. Nature 206:489–490

    Article  CAS  PubMed  Google Scholar 

  2. Seeman E (2008) Bone quality: the material and structural basis of bone strength. J Bone Miner Metab 26:1–8

    Article  PubMed  Google Scholar 

  3. Riggs BL, Khosla S, Melton LJ 3rd (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23:279–302

    Article  CAS  PubMed  Google Scholar 

  4. Tatsuno I, Terano T, Nakamura M, Suzuki K, Kubota K et al (2013) Lifestyle and osteoporosis in middle-aged and elderly women: Chiba bone survey. Endocr J 60:643–650

    Article  PubMed  Google Scholar 

  5. Melton LJ 3rd (1993) Hip fractures: a worldwide problem today and tomorrow. Bone 14(Suppl 1):S1–S8

    Article  PubMed  Google Scholar 

  6. Yi H, Ha YC, Lee YK, Lim YT (2013) National healthcare budget impact analysis of the treatment for osteoporosis and fractures in Korea. J Bone Metab 20:17–23

    Article  PubMed Central  PubMed  Google Scholar 

  7. Kang BJ, Lee YK, Lee KW, Won SH, Ha YC et al (2012) Mortality after hip fractures in nonagenarians. J Bone Metab 19:83–86

    Article  PubMed Central  PubMed  Google Scholar 

  8. Prescott SM, Zimmerman GA, Stafforini DM, McIntyre TM (2000) Platelet-activating factor and related lipid mediators. Annu Rev Biochem 69:419–445

    Article  CAS  PubMed  Google Scholar 

  9. Ishii S, Shimizu T (2000) Platelet-activating factor (PAF) receptor and genetically engineered PAF receptor mutant mice. Prog Lipid Res 39:41–82

    Article  CAS  PubMed  Google Scholar 

  10. Ishii S, Kuwaki T, Nagase T, Tashiro F, Sunaga S et al (1998) Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor. J Exp Med 187:1779–1788

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  11. Ishii S, Nagase T, Shindou H, Takizawa H, Ouchi Y et al (2004) Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. J Immunol 172:7095–7102

    Article  CAS  PubMed  Google Scholar 

  12. Montrucchio G, Alloatti G, Camussi G (2000) Role of platelet-activating factor in cardiovascular pathophysiology. Physiol Rev 80:1669–1699

    CAS  PubMed  Google Scholar 

  13. Noguchi K, Morita I, Murota S (1989) The detection of platelet-activating factor in inflamed human gingival tissue. Arch Oral Biol 34:37–41

    Article  CAS  PubMed  Google Scholar 

  14. Pettipher ER, Higgs GA, Henderson B (1987) PAF-acether in chronic arthritis. Agents Actions 21:98–103

    Article  CAS  PubMed  Google Scholar 

  15. Zheng ZG, Wood DA, Sims SM, Dixon SJ (1993) Platelet-activating factor stimulates resorption by rabbit osteoclasts in vitro. Am J Physiol 264:E74–E81

    CAS  PubMed  Google Scholar 

  16. Wood DA, Hapak LK, Sims SM, Dixon SJ (1991) Direct effects of platelet-activating factor on isolated rat osteoclasts. Rapid elevation of intracellular free calcium and transient retraction of pseudopods. J Biol Chem 266:15369–15376

    CAS  PubMed  Google Scholar 

  17. Hikiji H, Ishii S, Shindou H, Takato T, Shimizu T (2004) Absence of platelet-activating factor receptor protects mice from osteoporosis following ovariectomy. J Clin Invest 114:85–93

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  18. Kiel D (1995) Assessing vertebral fractures. National Osteoporosis Foundation Working Group on vertebral fractures. J Bone Miner Res 10:518–523

    CAS  PubMed  Google Scholar 

  19. Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137–1148

    Article  CAS  PubMed  Google Scholar 

  20. Feng X, McDonald JM (2011) Disorders of bone remodeling. Annu Rev Pathol 6:121–145

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  21. Weitzmann MN, Pacifici R (2006) Estrogen deficiency and bone loss: an inflammatory tale. J Clin Invest 116:1186–1194

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  22. Manolagas SC (2000) Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21:115–137

    CAS  PubMed  Google Scholar 

  23. Gowen M, Mundy GR (1986) Actions of recombinant interleukin 1, interleukin 2, and interferon-gamma on bone resorption in vitro. J Immunol 136:2478–2482

    CAS  PubMed  Google Scholar 

  24. Benveniste J, Henson PM, Cochrane CG (1972) Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor. J Exp Med 136:1356–1377

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. Madeira MF, Queiroz-Junior CM, Costa GM, Werneck SM, Cisalpino D et al (2013) Platelet-activating factor receptor blockade ameliorates Aggregatibacter actinomycetemcomitans-induced periodontal disease in mice. Infect Immun 81:4244–4251

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  26. Green S, Anstiss CL, Fishman WH (1971) Automated differential isoenzyme analysis. II. The fractionation of serum alkaline phosphatases into “liver”, “intestinal” and “other” components. Enzymologia 41:9–26

    CAS  PubMed  Google Scholar 

  27. van Straalen JP, Sanders E, Prummel MF, Sanders GT (1991) Bone-alkaline phosphatase as indicator of bone formation. Clin Chim Acta 201:27–33

    Article  PubMed  Google Scholar 

  28. Ross PD, Fujiwara S, Huang C, Davis JW, Epstein RS et al (1995) Vertebral fracture prevalence in women in Hiroshima compared to Caucasians or Japanese in the US. Int J Epidemiol 24:1171–1177

    Article  CAS  PubMed  Google Scholar 

  29. Ling X, Cummings SR, Mingwei Q, Xihe Z, Xioashu C et al (2000) Vertebral fractures in Beijing, China: the Beijing Osteoporosis Project. J Bone Miner Res 15:2019–2025

    Article  CAS  PubMed  Google Scholar 

  30. Hudry-Clergeon H, Stengel D, Ninio E, Vilgrain I (2005) Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3′-kinase. Faseb J 19:512–520

    Article  CAS  PubMed  Google Scholar 

  31. Prescott SM, McIntyre TM, Zimmerman GA, Stafforini DM (2002) Sol Sherry lecture in thrombosis: molecular events in acute inflammation. Arterioscler Thromb Vasc Biol 22:727–733

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This study was supported by grants from the Korea Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (project no. HI13C1634 and HI13C1432)

Conflict of interest

All authors have no conflicts of interest.

Author information

Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Poongnap2-Dong, Songpa-Gu, Seoul, 138-736, Korea

    Hyeonmok Kim, Beom-Jun Kim, Seong Hee Ahn, Seung Hun Lee & Jung-Min Koh

Authors
  1. Hyeonmok Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Beom-Jun Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Seong Hee Ahn
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Seung Hun Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jung-Min Koh
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Beom-Jun Kim.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kim, H., Kim, BJ., Ahn, S.H. et al. Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women. J Bone Miner Metab 33, 701–707 (2015). https://doi.org/10.1007/s00774-014-0634-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00774-014-0634-2

Keywords

Search

Navigation