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Investigation by ESR Spectroscopy of Biology Active Electron-Rich 1,10-Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

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Abstract

The 1,10-phenanthrocyanines of d-elements were investigated by ESR spectroscopy both in the solid (glassy) state and in solutions. These are coordination compounds of a new structural class of apocyanines: chromophore binuclear cation complexes [M2+Ln(µ-PC)]2Xm (M2+ = Zn2+, Cd2+, Co2+, Pd2+and Pt2+; L = 1,10-phenanthroline, 2,9-Me2-1,10-phenanthroline, pyridine; X = AcO−, Cl−) with electron-rich bridged 1,10-phenanthrocyanine ligands µ-PC. They are presented as soft colloidal glasses capable of acting as inhibitors of tumor cell proliferation, fungicides and DNA complexones. The study of them by ESR spectroscopy showed that one of the possible mechanisms for the formation of spin centers is thermally directed singlet–triplet S0 → Tlow.-transitions.

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Availability of Data and Materials

The materials are available in the databases of the Resource Center "Magnetic Resonance Research Methods" of St. Petersburg State University and the Institute of Silicate Chemistry of the Russian Academy of Sciences. All authors have reviewed the manuscript.

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Acknowledgements

The authors thank Prof. Doctor of Biological Sciences V.V. Sharoiko (Laboratory of Biomedical Chemistry, Institute of Chemistry, St. Petersburg State University, Universitetsky pr., 26, 198504, Peterhof, and Department of General and Bioorganic Chemistry, Pavlov First Saint Petersburg State Medical University, L’va Tolstogo str., 6–8, 197022, Saint Petersburg, Russia) for the study of cytotoxicity activity of Zn(II) complexes.

Funding

The work was carried out at the ISC RAS within the framework of the theme of the state budget: “Physico-chemical bases of inorganic synthesis of micro- and nanostructured non-organic, organo-non-organic and ceramic materials and coatings for bio-, energy- and resource-saving technologies” (1021050501070-0-1.4.3, No. 0097-2022-0006); as well as by V.L. Komarov Botanical Institute of the Russian Academy of Sciences, state budget theme: 122011900033-4, “Biodiversity, ecology and structural and functional features of fungi and fungi-like protists”.

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Authors and Affiliations

  1. Laboratory of Inorganic Synthesis, I.V. Grebenshchikov Institute of Silicate Chemistry of the Russian Academy of Sciences, Makarov Emb., 2, 199034, Saint Petersburg, Russia

    Viktor N. Demidov & Alexandra G. Ivanova

  2. Resource Center “magnetic resonance methods of investigation”, St. Petersburg State University, Universitetsky Pr., 26, 198504, Peterhof, Russia

    Stanislav M. Sukharzhevsky

  3. Department of Inorganic Chemistry, St. Petersburg State Technological Institute (Technical University), Moskovsky pr., 24-26/49 lit. A, 190013, Saint Petersburg, Russia

    Tatiana B. Pakhomova

  4. Department of Molecular Biophysics and Polymer Physics, St. Petersburg State University, Ulyanovskaya Str., 1, 198504, Peterhof, Russia

    Sofia V. Paston

  5. Laboratory of Systematics and Geography of Fungi, V.L. Komarov Botanical Institute of the Russian Academy of Sciences, prof. Popova Str., 2, 197376, Saint Petersburg, Russia

    Evgenia V. Bogomolova

Authors
  1. Viktor N. Demidov
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  2. Stanislav M. Sukharzhevsky
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  3. Tatiana B. Pakhomova
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  4. Alexandra G. Ivanova
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  5. Sofia V. Paston
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  6. Evgenia V. Bogomolova
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Contributions

VND wrote a manuscript, synthesized compounds, participated in the formulation of the concept (while performing the main role), participated in the measurement of ESR spectra, SMS measured ESR spectra, TBP participated in the synthesis of compounds and depicted structural formulas, AGI participated in the formulation of the concept, SVP investigated the interaction of complexes with DNA, EVB investigated the fungistatic activity of complexes.

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Correspondence to Viktor N. Demidov.

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Demidov, V.N., Sukharzhevsky, S.M., Pakhomova, T.B. et al. Investigation by ESR Spectroscopy of Biology Active Electron-Rich 1,10-Phenanthrocyanines of d-Elements (Soft Colloidal Glasses). Appl Magn Reson 54, 1015–1051 (2023). https://doi.org/10.1007/s00723-023-01586-z

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