Skip to main content
SpringerLink
Log in

Study of Molecular Dynamics in Paracetamol and Sulfanilamide Polymorphs by 1H NMR Relaxometry

  • Original Paper
  • Published:
Applied Magnetic Resonance Aims and scope Submit manuscript

Abstract

In this work, a new approach is applied to the study of the dynamics of molecular crystals in various polymorphic modifications using the distributions of T1 and T2 relaxation times for proton NMR. The distributions of relaxation times for different polymorphic states of paracetamol and sulfanilamide are obtained and analyzed. The multimodality of distributions is interpreted by the different nature of the motion of atoms located in different places of the crystal lattice. It is shown that the spectra of spin–lattice relaxation times for polymorphs of the same substance are not identical, as the spin–spin relaxation times spectra are. The results obtained may represent a new approach to quality control by the production of pharmaceutical compounds.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. M. Li, W. Xu, Y. Su, Trends Anal. Chem. 135, 116152 (2021)

    Article  Google Scholar 

  2. A. Becht, C. Schollmayer, Yu. Monakhova, U. Holzgrabe, Anal. Bioanal. Chem. 413, 3107 (2021)

    Article  Google Scholar 

  3. A. Portieri, R.K. Harris, R.A. Fletton, R.W. Lancaster, T.L. Threlfall, Magn. Reson. Chem. 42, 313 (2004)

    Article  Google Scholar 

  4. H.O. Lin, N.C. Baenziger, J.K. Guillory, J. Pharm. Sci. 63(1), 145 (1974)

    Article  Google Scholar 

  5. B.H. O’Connor, E.N. Maslen, Acta Cryst. 18, 363 (1965)

    Article  Google Scholar 

  6. A.M. O’Connell, E.N. Maslen, Acta Cryst. 22, 134 (1967)

    Article  Google Scholar 

  7. R. Blinc, J. Seliger, A. Zidansek, V. Zagar, F. Milia, H. Robert, Solid State Nucl. Magn. Reson. 30, 61 (2006)

    Article  Google Scholar 

  8. N.Y. Sinyavsky, I.G. Mershiev, G.S. Kupriyanova, Solid State Nuclear Magn. Reson. 78, 45 (2016)

    Article  Google Scholar 

  9. D.V. Snegirev, N.Y. Sinyavsky, G.S. Kupriyanova, Chem. Phys. Lett. 750, 137510 (2020)

    Article  Google Scholar 

  10. D. Stueber, S. Jehle, J. Pharm. Sci. 106(7), 1828 (2017)

    Article  Google Scholar 

  11. D. Stueber., S. Jehle, U.S. Patent Application n. 16/072,629 (2019)

  12. K. Okada, D. Hirai, S. Kumada et al., J. Pharm. Sci. 108(1), 451 (2018)

    Article  Google Scholar 

  13. K. Okada, D. Hirai, Y. Hayashi et al., Chem. Pharm. Bull. 67(6), 580 (2019)

    Article  Google Scholar 

  14. K. Okada, Y. Hayashi, S. Kumada, Y. Onuki, Eur. J. Pharm. Sci. 164, 105908 (2021)

    Article  Google Scholar 

  15. A. Pajzderska, J. Wąsicki, Int. J. Pharm. 605, 120800 (2021)

    Article  Google Scholar 

  16. S.W. Provencher, Comput. Phys. Commun. 27(3), 213 (1982)

    Article  ADS  Google Scholar 

  17. I.-G. Marino, http://www.mathworks.com/matlabcentral/fileexchange/6523-rilt/content/rilt.m [Electronic resource] (2004)

  18. D.A. Druzhbin, T.N. Drebushchak, V.E. Min’kov, E.V. Boldyreva, J. Struct. Chem. 56(2), 317 (2015)

    Article  Google Scholar 

  19. Z. Trontelj, J. Pirnat, V. Jazbinšek et al., J. Crystals 10, 450 (2020)

    Article  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Christian G. F. Blum (IFW Dresden institute) for the help with samples preparation.

Author information

Authors and Affiliations

  1. Department of Physics, Kaliningrad State Technical University, Sovetskiy Ave. 1, 236022, Kaliningrad, Russia

    Nikolay Sinyavsky

  2. Immanuel Kant Baltic Federal University, A. Nevskogo St. 14, 236041, Kaliningrad, Russia

    I. Mershiev

Authors
  1. Nikolay Sinyavsky
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Mershiev
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nikolay Sinyavsky.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sinyavsky, N., Mershiev, I. Study of Molecular Dynamics in Paracetamol and Sulfanilamide Polymorphs by 1H NMR Relaxometry. Appl Magn Reson 53, 931–939 (2022). https://doi.org/10.1007/s00723-022-01472-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00723-022-01472-0

Search

Navigation