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Assessment of Combined Therapy of Histochrome and Nebivalol as Angioprotectors on the Background of Experimental Hypertension by Magnetic Resonance Angiography

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Abstract

The renovascular model of arterial hypertension (AH) was induced in Wistar and OXYS strains. The model of AH was verified by magnetic resonance angiography. It was shown that histochrome enhances the vasodilatory effect of selective beta1 blocker, nebivalol, against cerebral and renal arteries using a combined therapy in this model. Monotherapy with histochrome had no significant effect on blood pressure. The angioprotective effect of histochrome in the combined therapy was significantly more expressed in hypertensive OXYS rats compared to hypertensive Wistar rats as shown by magnetic resonance imaging (MRI) morphometry. These differences were more observable in the intrarenal part of renal arteries. The degree of regional discirculation of arteries was calculated by the Cerebro-Renal Vascular Index, which confirms the therapeutic advantage of combined therapy with histochrome and nebivalol in the background of AH. Thus, comparative MRI angiography and MRI morphometry of the cerebral and renal arteries in hypertensive Wistar and OXYS strain rats showed that histochrome expands the therapeutic potential of nebivalol due to angioprotective effects in the vascular region of the target organs.

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Acknowledgements

The research is partially supported by a FEBRAS Grant No 15-I-5-006. The study was carried out using equipment of the “Far Eastern Center of Noninvasive Radio-Frequency Diagnostics of Biological Objects” (FECNRFD) of the G.B. Elyakov Pacific Institute of Bioorganic Chemistry of FEBRAS.

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Authors and Affiliations

  1. G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branches of the Russian Academy of Sciences, Vladivostok, Russia

    Irina G. Agafonova & Valentin A. Stonik

  2. Far Eastern Branches of the State Research and Test Institute of Military Medicine of the Ministry Defense of the Russian Federation, Vladivostok, Russia

    Vladimir N. Kotelnikov

  3. Far Eastern Federal University, Vladivostok, Russia

    Boris I. Geltser

  4. Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk State University, Novosibirsk, Russia

    Natalya G. Kolosova

Authors
  1. Irina G. Agafonova
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  2. Vladimir N. Kotelnikov
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  3. Boris I. Geltser
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  4. Natalya G. Kolosova
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  5. Valentin A. Stonik
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Correspondence to Irina G. Agafonova.

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Agafonova, I.G., Kotelnikov, V.N., Geltser, B.I. et al. Assessment of Combined Therapy of Histochrome and Nebivalol as Angioprotectors on the Background of Experimental Hypertension by Magnetic Resonance Angiography. Appl Magn Reson 49, 217–225 (2018). https://doi.org/10.1007/s00723-017-0960-3

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  • DOI: https://doi.org/10.1007/s00723-017-0960-3

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