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Characterization of kinetic, thermodynamic, and binding properties of l-phenylalanine molecularly imprinted polymer

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Abstract

l-Phenylalanine imprinted polymeric adsorbent was fabricated by a non-covalent approach utilizing methacrylic acid as functional monomer, ethylene glycol dimethacrylate as cross-linker, acetonitrile as porogen, and acetic acid and trifluoroacetic acid as additives (template:monomer:cross-linker ratio was 1:5:24). Adsorption equilibrium, kinetic, thermodynamic, and enantioselective studies were carried out characterization of adsorbent. Parallel studies were performed for the binding of enantiomers on non-imprinted polymer. The experimental l- and d-phenylalanine adsorption-binding isotherms were fitted with hybrid Langmuir–Freundlich model. Studies have demonstrated a heterogeneous distribution of binding sites, site with high and low binding affinity, in polymer. The thermodynamic test revealed the entropy controlled adsorption process on l-phenylalanine imprinted adsorbent. Kinetic studies indicated second-order rate adsorption process. The adsorbent is characterized by enantioselectivity for recognition of phenylalanine enantiomers.

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Acknowledgements

This research was supported by the Scientific Grant Agency VEGA of the Slovak Republic under Grant number 1/0159/20). Authors thanks to Assoc. prof. J. Sádecká, PhD. for realization spectrofluorescence measurements.

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Authors and Affiliations

  1. Faculty of Chemical and Food Technology, Institute of Analytical Chemistry, Slovak University of Technology in Bratislava, Radlinského 9, 812 37, Bratislava, Slovak Republic

    Katarína Hroboňová, Veronika Vybohová, Anna Lomenova, Andrea Špačková & Veronika Svitková

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  1. Katarína Hroboňová
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  2. Veronika Vybohová
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  3. Anna Lomenova
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  4. Andrea Špačková
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  5. Veronika Svitková
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Correspondence to Katarína Hroboňová.

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Hroboňová, K., Vybohová, V., Lomenova, A. et al. Characterization of kinetic, thermodynamic, and binding properties of l-phenylalanine molecularly imprinted polymer. Monatsh Chem 153, 1037–1047 (2022). https://doi.org/10.1007/s00706-022-02900-4

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  • DOI: https://doi.org/10.1007/s00706-022-02900-4

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