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An updated research of glycogen synthase kinase-3β inhibitors: a review

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Abstract

Glycogen synthase kinase-3β (GSK-3β) is a highly conserved multifunctional serine/threonine (Ser/Thr) protein kinase widely expressed in many tissues. GSK-3β inhibitors could be used in the treatment of human key diseases, such as cancer, Alzheimer’s disease, Parkinson’s disease, inflammation, type-II diabetes, and so on, due to the multi-role of GSK-3β in the hepatic glycolysis regulation, cell signaling pathways, and phosphorylation of various proteins. Recently, sets of diverse GSK-3β inhibitors have been prepared, and biologically evaluated in vitro and in vivo in different screening models. This review summarizes the latest developments in GSK-3β inhibitors unclosed from 2015 to 2019, including their structure–activity relationship and bioactivity studies.

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Acknowledgements

This research work was financially supported by the Natural Science Foundation of China [No. 21672082], Major Science and Technology Innovation Project of Shandong Province [No. 2019JZZY011116], and Shandong Talents Team Cultivation Plan of University Preponderant Discipline [No. 10027].

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Authors and Affiliations

  1. School of Biological Science and Technology, University of Jinan, Jinan, 250022, China

    Shan-Kui Liu, Hong-Xu Xie, Yong-Xi Ge, Juan Zhang & Cheng-Shi Jiang

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Correspondence to Juan Zhang or Cheng-Shi Jiang.

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Liu, SK., Xie, HX., Ge, YX. et al. An updated research of glycogen synthase kinase-3β inhibitors: a review. Monatsh Chem 152, 19–33 (2021). https://doi.org/10.1007/s00706-020-02718-y

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