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A green, efficient, and rapid procedure for the hydrogenation of nitroarenes to formanilides in water

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Abstract

A green, efficient, and rapid procedure for the hydrogenation of nitroarenes to formanilides in Pd(TFA)2/HCOOH system in water is described. Under optimized conditions, the reaction of most substrates is complete within 30 min with yields of 30–93%. Furthermore, this procedure is applied successfully for the modification of natural products, such as arctigenin, vindoline, and estrone.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant: 81473110), Special Fund for Strategic Pilot Technology Chinese Academy of Sciences (XDA12040303), Shanghai Science and Technology Support Program (13431900401).

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Authors and Affiliations

  1. College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, 310032, People’s Republic of China

    Yingying Wang & Zhajun Zhan

  2. Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People’s Republic of China

    Yang Zhou & Min Lei

  3. Jiangsu Key Laboratory for Functional Substance of Chinese Medicine, Stake Key Laboratory Cultivation Base for TCM Quality and Efficacy, School of Pharmacy, Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China

    Lihong Hu

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  1. Yingying Wang
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  2. Zhajun Zhan
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  3. Yang Zhou
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  4. Min Lei
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  5. Lihong Hu
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Corresponding authors

Correspondence to Min Lei or Lihong Hu.

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Wang, Y., Zhan, Z., Zhou, Y. et al. A green, efficient, and rapid procedure for the hydrogenation of nitroarenes to formanilides in water. Monatsh Chem 149, 527–533 (2018). https://doi.org/10.1007/s00706-017-2071-0

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  • DOI: https://doi.org/10.1007/s00706-017-2071-0

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