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Kinetic and thermodynamic studies of methotrexate adsorption on chitosan-modified magnetic multi-walled carbon nanotubes

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Abstract

A new type of drug delivery system involved chitosan (CS)-modified magnetic multi-walled carbon nanotubes (M-CS-MWNTs) was synthesized. Prepared M-CS-MWNTs was characterized by Fourier transform infrared spectroscopy, scanning electron microscope, thermogravimetric analysis, X-ray diffraction, and CHN techniques. The nanocarrier was used for controllable loading and release of anticancer drug methotrexate. The full factorial design methodology was employed to obtain the optimum conditions for time, dose of adsorbent, initial methotrexate concentration, and pH of preparative media on the drug loading efficiency, by using Minitab 16 and Design Expert 7.1.6 software. The maximum loading (89 %) was achieved under optimized condition (pH: 7.0, time: 35 min, methotrexate concentration: 20 mg dm−3, and M-CS-MWNTs dosage: 0.20 g dm−3). The adsorption isotherm and other properties including kinetics and thermodynamics were studied. Pseudo-second order shows the best fitting of methotrexate adsorption. The thermodynamic studies showed that the adsorption of methotrexate on nanocarrier is spontaneous and exothermic in nature.

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Acknowledgments

The authors gratefully acknowledge the support of this work by the Imam Khomeini international university, Qazvin, Iran for financial support and providing laboratory facilities for this work.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Imam Khomeini International University, PO Box 288, Qazvin, 34149, Islamic Republic of Iran

    Bahman Vasheghani Farahani & Nasrin Javadi

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  1. Bahman Vasheghani Farahani
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  2. Nasrin Javadi
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Correspondence to Bahman Vasheghani Farahani.

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Vasheghani Farahani, B., Javadi, N. Kinetic and thermodynamic studies of methotrexate adsorption on chitosan-modified magnetic multi-walled carbon nanotubes. Monatsh Chem 147, 2051–2060 (2016). https://doi.org/10.1007/s00706-016-1753-3

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  • DOI: https://doi.org/10.1007/s00706-016-1753-3

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