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Hepatitis B virus and hepatitis C virus infection among HIV-1-infected injection drug users in Dali, China: prevalence and infection status in a cross-sectional study

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Abstract

To assess the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and to investigate their mutual influences on infection status among human immunodeficiency virus type 1 (HIV-1)-seropositive injection drug users (IDUs). A cross-sectional study was conducted among HIV infected IDUs in Dali, China. The participants were tested for serological markers of HBV and HCV infection, alanine transaminase (ALT) activity and CD4+ T cell count. HCV genotype was determined by sequencing. Of 529 patients, 498 (94.1 %) HIV infected IDUs agreed to participate. The overall prevalence of HCV infection (anti-HCV antibody positive) and spontaneous HCV clearance were 90.8 % (452/498) and 21.5 % (97/452), respectively. Of 411 subjects who had not received HBV vaccine, 296 (72.0 %) were positive for antibody against HBV core antigen (HBcAb), while 274 (66.7 %) were positive for both HCV antibody and HBcAb. HBV antigens were detected in 52 of the HBV-infected subjects (17.6 %). HCV clearance was associated with HBV antigenemia (p = 0.0002) and higher CD4+ T cell count (p = 0.0294). Resolved HBV infection was associated with HCV genotype 3 (p = 0.0365). HBV and HCV infection are highly prevalent and mutually influence infection status in HIV-1 infected IDUs in Dali, China.

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The authors declare that they have no conflict of interest.

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    Authors and Affiliations

    1. Shanghai Public Health Clinical Center and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health at Shanghai Medical College, Fudan University, Research Bldg, Rm 308, 2901 Caolang Road, Jinshan District, Shanghai, 201508, China

      Yuan Dong, Chao Qiu, Jing Wang, Xiaoyan Zhang & Jianqing Xu

    2. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China

      Xueshan Xia

    3. Dali Municipal Centers for Disease Control and Prevention, Yunnan, China

      Haiyan Zhang

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    1. Yuan Dong
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    2. Chao Qiu
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    3. Xueshan Xia
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    4. Jing Wang
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    5. Haiyan Zhang
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    6. Xiaoyan Zhang
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    Correspondence to Xiaoyan Zhang or Jianqing Xu.

    Additional information

    Y. Dong, C. Qiu and X. Xia equally contributed to this work.

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    Dong, Y., Qiu, C., Xia, X. et al. Hepatitis B virus and hepatitis C virus infection among HIV-1-infected injection drug users in Dali, China: prevalence and infection status in a cross-sectional study. Arch Virol 160, 929–936 (2015). https://doi.org/10.1007/s00705-014-2311-0

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    • DOI: https://doi.org/10.1007/s00705-014-2311-0

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