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Genome sequence of a pathogenic isolate of monkey B virus (species Macacine herpesvirus 1)

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Abstract

The only genome sequence for monkey B virus (BV; species Macacine herpesvirus 1) is that of an attenuated vaccine strain originally isolated from a rhesus monkey (BVrh). Here we report the genome sequence of a virulent BV strain isolated from a cynomolgus macaque (BVcy). The overall genome organization is the same, although sequence differences exist. The greatest sequence divergence is located in non-coding areas of the long and short repeat regions. Like BVrh, BVcy has duplicated Ori elements and lacks an ORF corresponding to the γ34.5 gene of herpes simplex virus. Nine of ten miRNAs and the majority of ORFs are conserved between BVrh and BVcy. The most divergent genes are several membrane-associated proteins and those encoding immediate early proteins.

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Acknowledgments

This work was partially supported by grants P40 OD010988 and P40 OD010431 from the National Institutes of Health (DB, RE) and Grant-in Aid for Scientific Research B #19300148 from the Ministry of Education, Culture, Sport, Science and Technology of Japan (KO, MO).

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Authors and Affiliations

  1. Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, OK, 74078, USA

    Darla Black & R. Eberle

  2. Division of Comparative Medicine, Center for Frontier Life Sciences, Nagasaki University, Nagasaki, Japan

    Kazutaka Ohsawa & Makiko Ohsawa

Authors
  1. Kazutaka Ohsawa
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  2. Darla Black
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  3. Makiko Ohsawa
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  4. R. Eberle
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Corresponding author

Correspondence to R. Eberle.

Additional information

The GenBank accession number for the BVcy strain E90-136 genome sequence is KJ566591.

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Ohsawa, K., Black, D., Ohsawa, M. et al. Genome sequence of a pathogenic isolate of monkey B virus (species Macacine herpesvirus 1). Arch Virol 159, 2819–2821 (2014). https://doi.org/10.1007/s00705-014-2130-3

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  • DOI: https://doi.org/10.1007/s00705-014-2130-3

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