Abstract
To investigate the association between autonomic dysfunction (AutD) and motor as well as non-motor symptoms (NMS) in patients with Parkinson's disease (PD). Fifty-three PD patients were divided into two groups based on the number of domains affected by AutD: a multi-domain AutD group (AutD-M) and a single-domain AutD group (AutD-S), as evaluated using the Scale for Outcomes in Parkinson's disease-Autonomic (SCOPA-AUT), which assesses autonomic symptoms, one of the NMS. A comprehensive comparison was conducted between the two groups, including clinical measures such as clinical scales, quantitative evaluations of motor function and exercise capacity. Spearman correlation analysis was employed to investigate the relationship between AutD severity and PD symptoms. Additionally, we performed multiple linear regression model analysis to determine whether associations between SCOPA-AUT scores and clinical assessments remained significant after adjusting for Hoehn and Yahr stage, sex, and age. PD patients in the AutD-M group exhibited significantly more severe NMS and motor symptoms compared to those in the AutD-S group. In correlation analysis, SCOPA-AUT scores showed significant correlations with multiple clinical symptoms, such as most of the NMS, 10-MWT and CPET parameters. Furthermore, regression analysis also revealed that more pronounced fatigue, anxiety, depressive symptoms, worse walking speed and impaired exercise capacity were associated with higher SCOPA-AUT scores. The presence of AutD is correlated with emotional disturbances, decreased exercise endurance, and impaired gait function in patients with PD. Early management of AutD may prove beneficial in alleviating some NMS and motor symptoms in PD.
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The data that support the findings of this study are available from the authors upon reasonable request and with permission.
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We would like to express our sincere gratitude to all the patients and medical staff of the Neurological Rehabilitation Center of Beijing Rehabilitation Hospital for their participation and assistance in the study.
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This study was supported by the Science and Technology Development Fund of Beijing Rehabilitation Hospital, Capital Medical University (2019R-006 for Zhao-hui Jin; 2021-011 for Bo-yan Fang; 2022-017 for Wen-junDu). The funding body had no role in protocol design, statistical analysis and manuscript preparation.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by [YQ], [De-TM], [Z-HJ], [W-D]and [B-YF]. The first draft of the manuscript was written by [Yi Qin] and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Qin, Y., Meng, DT., Jin, ZH. et al. Association between autonomic dysfunction with motor and non-motor symptoms in patients with Parkinson's disease. J Neural Transm 131, 323–334 (2024). https://doi.org/10.1007/s00702-024-02745-7
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DOI: https://doi.org/10.1007/s00702-024-02745-7