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Autophagy in trimethyltin-induced neurodegeneration

  • Neurology and Preclinical Neurological Studies - Review Article
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Abstract

Autophagy is a degradative process playing an important role in removing misfolded or aggregated proteins, clearing damaged organelles, such as mitochondria and endoplasmic reticulum, as well as eliminating intracellular pathogens. The autophagic process is important for balancing sources of energy at critical developmental stages and in response to nutrient stress. Recently, autophagy has been involved in the pathophysiology of neurodegenerative diseases although its beneficial (pro-survival) or detrimental (pro-death) role remains controversial. In the present review, we discuss the role of autophagy following intoxication with trimethyltin (TMT), an organotin compound that induces severe hippocampal neurodegeneration associated with astrocyte and microglia activation. TMT is considered a useful tool to study the molecular mechanisms occurring in human neurodegenerative diseases such as Alzheimer’s disease and temporal lobe epilepsy. This is also relevant in the field of environmental safety, since organotin compounds are used as heat stabilizers in polyvinyl chloride polymers, industrial and agricultural biocides, and as industrial chemical catalysts.

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Acknowledgements

This work was supported by grants from Sapienza University to CF (RM118164328DF7F2 and RM11916B88BF39BB).

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  1. Elena Pompili, Cinzia Fabrizi contributed equally to this paper.

Authors and Affiliations

  1. Department of Anatomy, Histology, Forensic Medicine and Orthopedics, Sapienza University of Rome, Via A. Borelli 50, 00161, Rome, Italy

    Elena Pompili, Cinzia Fabrizi & Lorenzo Fumagalli

  2. Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy

    Francesco Fornai

  3. IRCCS Neuromed, Pozzilli, Italy

    Francesco Fornai

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  1. Elena Pompili
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  2. Cinzia Fabrizi
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  4. Francesco Fornai
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Correspondence to Elena Pompili.

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Pompili, E., Fabrizi, C., Fumagalli, L. et al. Autophagy in trimethyltin-induced neurodegeneration. J Neural Transm 127, 987–998 (2020). https://doi.org/10.1007/s00702-020-02210-1

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