Abstract
Subjective cognitive complaints (SCC) are frequent in elderly populations. PD patients report SCC more often than healthy controls. The association between SCC, objective cognitive impairment and affective symptoms remains controversial. We assessed consecutive PD patients between March 2014 and March 2015. Presence of SCC was defined as a score ≥ 1 in the Non-Motor Symptom Assessment Scale for Parkinson’s Disease (NMSS) Domain 5. MoCA was used for cognitive impairment assessment. Pill Questionnaire measured the impact in daily activities. PD with Dementia (PDD) and PD with Mild Cognitive Impairment (PDMCI) were defined as the presence of cognitive impairment with or without impact on daily activities. Anxiety and depression were assessed using the Hospital Anxiety and Depression Scales. Significance was set at p < 0.05. From 134 patients, 128 were included. PDD was diagnosed in 21 (16.4%), PDMCI in 31 (24.2%), and 76 (59.4%) had normal cognition (PDCN). SCC were present in 85% of whole cohort and evenly distributed (p = 0.361), PDD (95.2%), PDMCI (83.9%) and PDCN (82.9%). Severity was significantly different between PDD (20.00 ± 10.81), PDMCI (6.54 ± 5.5) and PDCN (6.97 ± 6.98), p < 0.001. A score ≥ 19 had a specificity of 77.3% and a sensitivity of 78.8% for identifying PDD. In PDCN, SCC severity was found to be related to depression (OR 1.23, CI 95% 1.02–1.47, p = 0.026) more than with MoCA scores (OR: 0.86, CI 95% 0.69–1.05, p = 0.141). SCC are common in PD. Their severity can help distinguish PDD from non-demented PD patients. In PDCN, SCC should alert the clinician for an affective disorder.
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References
Aarsland D, Byron Creese B, Marios Politis M et al (2017) Cognitive decline in Parkinson disease. Nat Rev Neurol 13:217–231. https://doi.org/10.1038/nrneurol.2017.27
Bugalho P, Lampreia T, Miguel R, Mendonça M, Caetano A, Barbosa R (2016) Non-motor symptoms in portuguese Parkinson’s disease patients: correlation and impact on quality of life and activities of daily living. Sci Rep 30(6):32267. https://doi.org/10.1038/srep32267
Chaudhuri KR, Martinez-Martin P, Brown RG et al (2007) The metric properties of a novel non-motor symptoms scale for Parkinson’s disease: results from an international pilot study. Mov Disord 22:1901–1911. https://doi.org/10.1002/mds.21596
Dubois B, Burn D, Goetz C et al (2007) Diagnostic Procedures for Parkinson’s disease dementia: recommendations from the movement disorders society task force. Mov Disord 22:2314–2324. https://doi.org/10.1002/mds.21844
Dujardin K, Duhamel A, Delliaux M, Thomas-Antérion C, Destée A, Defebvre L (2010) Cognitive complaints in Parkinson’s disease: it’s relationship with objective cognitive decline. J Neurol 257:79–84. https://doi.org/10.1007/s00415-009-5268-2
Emre M, Aarsland D, Brown R et al (2007) Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Mov Disord 22(12):1689–1707. https://doi.org/10.1002/mds.21507
Erro R, Santangelo G, Pl Barone et al (2014) Do subjective memory complaints herald the onset of mild cognitive impairment in Parkinson disease? J Geriatr Psychiatry Neurol 7(4):276–281. https://doi.org/10.1177/0891988714532015
Fahn S et al (1987) Unified Parkinson’s disease rating scale (UPDRS). In: Fahn S, Marsden CD, Goldstein M, Calne DB (eds) Recent developments in Parkinson’s disease. McMillan Health Care, London, pp 153–163
Freitas S, Simões MR, Alves L, Santana I (2011) Montreal cognitive assessment (MoCA): normative study for the Portuguese population. J Clin Exp Neuropsychol 33(9):989–996. https://doi.org/10.1080/13803395.2011.589374
Gibb WR, Lees AJ (1998) The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson’s disease. J Neurol Neurosurg Psychiatry 51:745–752. https://doi.org/10.1136/jnnp.51.6.745
Ginó S, Mendes T, Maroco J (2010) Memory complaints are frequent but qualitatively different in young and elderly healthy people. Gerontology 56:272–277. https://doi.org/10.1159/000240048
Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17:427–442. https://doi.org/10.1212/WNL.17.5.427
Hong JY, Lee Y, Sunwoo MK, Sohn YH, Lee PH (2018) Subjective cognitive complaints and objective cognitive impairment in Parkinson’s disease. J Clin Neurol 14(1):16–21. https://doi.org/10.3988/jcn.2018.14.1.16
Jonker C, Geerlinhd MI, Schmands B (2000) Are memory complaints predictive for dementia? A review of clinical and population-based studies. Int J Geriatr Psychatry 15:983–991. https://doi.org/10.1002/1099-1166
Lehrner J, Moser D, Kulg S et al (2014) Subjective memory complaints, depressive symptoms and cognition in Parkinson’s disease patients. Eur J Neurol. 21:1276–1284. https://doi.org/10.1111/ene.12470
Litvan I, Goldman JG, Troster AI et al (2012) Diagnostic criteria for mild cognitive impairment in parkinson’s disease: movement disorders society task force guidelines. Mov Disord 27:349–356. https://doi.org/10.1002/mds.24893
Mendonça MD, Alves L, Bugalho P (2016) From subjective cognitive complaints to dementia: who is at risk?: a systematic review. Am J Alzheimer’s Disease Other Dement 31(2):105–114. https://doi.org/10.1177/1533317515592331
Nasredinne Z, Phillips NA, Bédirian V et al (2005) The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. Am Geriatr Soc 53(4):695–699. https://doi.org/10.1111/j.1532-5415.2005.53221.x
Perrotin A, Mormino EC, Madison CM, Hayenga AO, Jagust WJ (2012) Subjective cognition and amyloid deposition imaging: a Pittsburgh compound B positron emission tomography study in normal elderly individuals. Arch Neurol 69(2):223–229. https://doi.org/10.1001/archneurol.2011.666
Roy R, Niccolini F, Pagano G (2016) Cholinergic imaging in dementia spectrum disorders. Eur J Nucl Med Mol Imaging 43(6):1376–1386. https://doi.org/10.1007/s00259-016-3349-x
Santangelo G, Vitale C, Trajano L et al (2014) Subthereshold depression and subjective cognitive complaints in Parkinson’s disease. Eur J Neurol 21(3):541–544. https://doi.org/10.1111/ene.12219
Stewart R, Godin O, Crivello F et al (2011) Longitudinal neuroimaging correlates of subjective memory impairment: 4-year prospective community study. Br J Psychiatry 198(3):199–205. https://doi.org/10.1192/bjp.bp.110.078683
Strakstein SE, Mayberg HS, Preziosi TJ, Andrezejewski P, Leiguarda R, Robinson RG (1992) Reliability, validity and clinical correlates of apathy in Parkinson’s disease. J Neuropsychiatry Clin Neurosci 4:134–139. https://doi.org/10.1176/jnp.4.2.134
Visser PJ, Verhey F, Knol DL (2009) Prevalence and prognostic value of CSF markers of Alzheimer’s disease pathology in patients with subjective cognitive impairment or mild cognitive impairment in the DESCRIPA study: a prospective cohort study. Lancet Neurol 8(7):619–627. https://doi.org/10.1016/s1474-4422(09)70139-5
Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67:361–370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
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Barbosa, R.P., Mendonça, M.D., Caetano, A.P. et al. Cognitive complaints in Parkinson’s disease patients: from subjective cognitive complaints to dementia and affective disorders. J Neural Transm 126, 1329–1335 (2019). https://doi.org/10.1007/s00702-019-02042-8
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DOI: https://doi.org/10.1007/s00702-019-02042-8