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Quantitative evaluation of electroconvulsive therapy for Parkinson’s disease with refractory psychiatric symptoms

  • Psychiatry and Preclinical Psychiatric Studies - Original Article
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Abstract

Patients with advanced-stage Parkinson’s disease (PD) occasionally experience refractory depression or catatonic stupor. Electroconvulsive therapy (ECT) has been reported as a successful procedure for both severe psychosis and motor symptoms in patients with PD. Four patients with PD who were receiving ECT were quantitatively evaluated using the Unified PD Rating scale part III, Hoehn and Yahr scale, Barthel index, Neuropsychiatric Inventory, mini-mental state examination, Revised Hasegawa’s Dementia scale, Beck’s Depression Inventory, and Hamilton Rating Scale for Depression-17. We adopted the “half-age” method, which is an age-based stimulus-dosing method. The patients showed improvement in symptoms of psychosis and motor symptoms without any adverse effects. The interval of improvement after ECT varied among patients. Of note, a decrease in psychiatric symptoms successfully alleviated the burden of caregivers. ECT may be useful to treat parkinsonism with refractory psychosis, major depression, or catatonic stupor, within the limitations of the patients enrolled.

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The authors declare no financial or other conflict of interest.

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Authors and Affiliations

  1. Department of Neurology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8421, Japan

    Kenya Nishioka, Ryota Tanaka, Kazuoki Hirano, Taku Hatano & Nobutaka Hattori

  2. Department of Neurology, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan

    Hideki Shimura & Takao Urabe

  3. Department of Psychiatry, Juntendo University Urayasu Hospital, 2-1-1 Tomioka, Urayasu, Chiba, 279-0021, Japan

    Koichi Miyakawa

  4. Department of Psychiatry, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo, Tokyo, 113-8421, Japan

    Heii Arai

Authors
  1. Kenya Nishioka
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  2. Ryota Tanaka
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  3. Hideki Shimura
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  4. Kazuoki Hirano
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  5. Taku Hatano
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  6. Koichi Miyakawa
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  7. Heii Arai
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  8. Nobutaka Hattori
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  9. Takao Urabe
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Correspondence to Kenya Nishioka.

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Nishioka, K., Tanaka, R., Shimura, H. et al. Quantitative evaluation of electroconvulsive therapy for Parkinson’s disease with refractory psychiatric symptoms. J Neural Transm 121, 1405–1410 (2014). https://doi.org/10.1007/s00702-014-1212-4

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  • DOI: https://doi.org/10.1007/s00702-014-1212-4

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