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Delayed complete remission of hemifacial spasms following microvascular decompression and the implications for optimal time of revision surgery

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Abstract

Background

Microvascular decompression (MVD) is an effective method for directly treating hemifacial spasms (HFS). The timing for the consideration of failed MVD and reoperation has been paradoxical.

Objective

This study aimed to investigate the delayed complete remission of HFS in terms of prevalence rate, duration between surgery and delayed complete remission, and predictive factors.

Methods

A hundred patients with HFS who underwent MVD from 2012–2021 were enrolled in the study. All HFS occurred as a result of compression of the facial nerve by adjacent blood vessels. Clinical information, intraoperative findings, and surgical outcomes were incorporated for data analysis.

Results

In the first week after MVD, 67 of 100 patients achieved complete remission of HFS, while the remaining 33 had incomplete remission. In long-term follow-up, 26 individuals gradually developed delayed complete remission with a median duration of 9.1 months. Finally, 86 of 100 patients achieved complete long-term remission. Recurrent HFS and incomplete remission were found in 7 and 7 patients, respectively. Factors associated with postoperative complete remission in the first week were a severe degree of facial nerve compression (p = 0.047, OR 2.75, 95% CI 1.01–7.40), with long-term complete remission was left-sided HFS (p = 0.012, OR 5.73, 95% CI 1.47–22.36), and with the appearance of delayed complete remission was the prolonged duration of HFS at least 3 years before MVD (p = 0.046, OR 3.75, 95% CI 1.03–13.76). Transient facial paresis was found in 11% of the patients. Of them, facial nerve function recovered completely in all cases.

Conclusions

A delayed complete remission of HFS could be expected in long-term follow-up after MVD and is probably related to a longer duration of HFS before surgery. Unnecessary reoperation should be avoided in the early years following the first surgery.

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Acknowledgements

The authors gratefully acknowledge Saowalak Hunnangkul, Clinical Epidemiology Unit, Office of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, for assistance with statistical analysis.

Funding

No funding was received for this research.

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Authors and Affiliations

  1. Division of Neurosurgery, Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Wang Lang Road, Bangkok Noi, Bangkok, 10700, Thailand

    Sarun Nunta-aree, Thanthip Kateyoi & Bunpot Sitthinamsuwan

  2. Department of Surgery, Prajuabkirikhan Hospital, Prajuabkirikhan, Thailand

    Thanthip Kateyoi

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  1. Sarun Nunta-aree
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  2. Thanthip Kateyoi
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  3. Bunpot Sitthinamsuwan
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Correspondence to Bunpot Sitthinamsuwan.

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Ethical approval

The protocol for this study was approved by the Siriraj Institutional Review Board (SIRB), Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. This study complied with the principles set forth in the 1964 Declaration of Helsinki and all of its later amendments or with comparable ethical standards. Written informed consent was not required for this study.

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Nunta-aree, S., Kateyoi, T. & Sitthinamsuwan, B. Delayed complete remission of hemifacial spasms following microvascular decompression and the implications for optimal time of revision surgery. Acta Neurochir 166, 12 (2024). https://doi.org/10.1007/s00701-024-05891-9

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