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WHO grade, proliferation index, and progesterone receptor expression are different according to the location of meningioma

  • Original Article - Tumor - Meningioma
  • Published:
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Abstract

Background

Meningiomas may show a different WHO grade and variable biological and clinical behaviors. The aim of the present study is to assess whether WHO grade, proliferation index, progesterone receptor (PR) expression, histological subtype, neuroradiological features, and the recurrence rate differ depending on the tumor location.

Methods

Three hundred meningiomas operated on from 2006 to 2016 were reviewed. The WHO grade (2007 classification), Ki67-MIB1, progesterone receptor expression, and histological subtype were reexamined and correlated to the meningioma location, classified as medial skull base, lateral skull base, non-skull base, and spinal.

Results

Non-skull base and lateral skull base meningiomas showed significantly higher rates of atypical WHO II forms (34% and 25.5% respectively) than medial skull base (12.5%) and spinal ones (7%) (p = 0.0003) and also higher rates of tumors with Ki67-Li > 4% (42% and 38% vs 22% and 14%) (p = 0.0031). The rate of meningiomas with PR expression ≤ 50% was significantly lower in medial skull base (25%) than in non-skull base (48%) (p = 0.009). Meningothelial and transitional meningiomas were more frequent at the skull base (68.5% and 54.5%, respectively), the fibroblastic subtype at the non-skull base (48.5%), and the psammomatous at the spinal canal (50%) (p < 0.00001). Medial skull base and spinal meningiomas showed significantly lower size (p < 0.00001), lower rates of cases with lost arachnoid interface (p = 0.0022), and significantly lower recurrence rates (p = 0.0035) than lateral skull base and non-skull base meningiomas.

Conclusion

Medial skull base meningiomas show lower size, lower rate of atypical forms, lower Ki67-Li values, and significantly higher PR expression than those at the lateral skull base and non-skull base. This corresponds to lesser aggressiveness and lower recurrence rates.

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Authors and Affiliations

  1. Department of Neurosciences and Reproductive and Odontostomatological Sciences, Neurosurgical Clinic, “Federico II” University School of Medicine, 5, Via S. Pansini, 80131, Naples, Italy

    Francesco Maiuri, Giuseppe Mariniello, Marcello Barbato & Sergio Corvino

  2. Department of Advanced Biomedical Sciences, Section of Pathology, University “Federico II” of Naples, Naples, Italy

    Elia Guadagno & Marialaura Del Basso De Caro

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  1. Francesco Maiuri
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  2. Giuseppe Mariniello
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  3. Elia Guadagno
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  4. Marcello Barbato
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  6. Marialaura Del Basso De Caro
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Correspondence to Giuseppe Mariniello.

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Maiuri, F., Mariniello, G., Guadagno, E. et al. WHO grade, proliferation index, and progesterone receptor expression are different according to the location of meningioma. Acta Neurochir 161, 2553–2561 (2019). https://doi.org/10.1007/s00701-019-04084-z

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  • DOI: https://doi.org/10.1007/s00701-019-04084-z

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