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An association of peripheral nerve sheath tumors and lipomas

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Abstract

Background

We noticed the coexistence of peripheral nerve sheath tumors (PNST) with lipomas within a subgroup of our patients. Given the prevalence of lipomas in the general population, we sought to investigate the extent of coexistence of the two entities aiming at uncovering any plausible association between both.

Methods

A retrospective review of all peripheral nerve sheath tumors (sporadic and syndromic forms) treated by a single surgeon between January 2009 and August 2015 was done. We recorded demographics (i.e., gender, age at diagnosis, imaging information, time to diagnosis) in addition to the method of diagnosis, subtype, number and location of lipomas, if present.

Results

Over 6 years, 309 patients with PNST were operated/evaluated. These included 141 sporadic (schwannomas, neurofibromas) and 168 syndromic (neurofibromatosis type 1 and 2 and schwannomatosis). We found 32 patients [10.3%, 95% confidence interval (CI) = 7.43%–14.3%] with coexistent lipomas, some of whom also had a family member with lipoma (n = 3). Of these 26 had schwannomas, 3 had neurofibromas and 3 lacked definitive PNST histopathological diagnosis. Fourteen percent of patients with schwannomas and 2.9% of patients with neurofibromas had coexisting lipomas.

Conclusion

We believe there is an increased association of peripheral nerve tumors and lipomas overall.

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Acknowledgements

We would like to thank our statistician, Adam C. Bartley, for his critical review and modification of manuscript statistical analysis.

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Authors and Affiliations

  1. Department of Neurologic Surgery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA

    Mohamed A. Elsherif & Robert J. Spinner

  2. Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA

    Dusica Babovic-Vuksanovic

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  1. Mohamed A. Elsherif
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  2. Dusica Babovic-Vuksanovic
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  3. Robert J. Spinner
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Corresponding author

Correspondence to Robert J. Spinner.

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All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Patient Consent

Informed consent was obtained from all individual participants included in the study.

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No funding was received for this research.

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Elsherif, M.A., Babovic-Vuksanovic, D. & Spinner, R.J. An association of peripheral nerve sheath tumors and lipomas. Acta Neurochir 159, 185–190 (2017). https://doi.org/10.1007/s00701-016-3038-3

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  • DOI: https://doi.org/10.1007/s00701-016-3038-3

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