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Label-free “signal-off” PEC aptasensor for determination of kanamycin based on 3D nanoflower-like FeIn2S4/CdS Z-scheme heterostructures

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Abstract

Highly photoactive 3D nanoflower-like FeIn2S4/CdS heterostructures were synthesized by hydrothermal treatment and low-temperature cation exchange. The FeIn2S4/CdS displayed 14.5 times signal amplification in contrast to FeIn2S4 alone. It was applied as a photoactive substrate to construct a label-free photoelectrochemical (PEC) aptasensor for ultrasensitive determination of kanamycin (KAN). Under the optimal conditions, the constructed PEC aptasensor displayed a wide linear range (5.0 × 10−4 ~ 5.0 × 101 ng mL−1) and a low detection limit (S/N = 3) of 40.01 fg mL−1. This study provides some constructive insights for preparation of advanced photoactive materials and exhibits great potential for quantitative determination of antibiotics in foods and environmental samples.

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The data underlying this article are available in the article and in its online supplementary material.

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Funding

This research was supported by National Natural Science Foundation of China (22204143), Natural Science Foundation of Zhejiang Province (LQ22B050006, and LQ21C060003), Jinhua Science and Technology Bureau (2021–3-058), Medical and Health Research Project of Zhejiang Province (2022KY424), State Key Laboratory of Analytical Chemistry for Life Science (SKLACLS2213), Research Fund of Jinhua Municipal Central Hospital (JY2021-5–03), and Key Laboratory of Watershed Earth Surface Processes and Ecological Security, Zhejiang Normal University (KF-2022–14).

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Authors and Affiliations

  1. Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Materials Science, College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua, 321004, China

    Fang-Fang Xin, Pei Song, Ke-Ming Fang, Zhi-Gang Wang, Ai-Jun Wang, Li-Ping Mei & Jiu-Ju Feng

  2. Central Laboratory, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, China

    Pei Song

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  1. Fang-Fang Xin
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Correspondence to Li-Ping Mei or Jiu-Ju Feng.

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Research highlights

• 3D nanoflower-like FeIn2S4/CdS Z-scheme heterostructures were prepared as an ideal photoactive material.

• FeIn2S4/CdS Z-type heterojunctions facilitated the separation and transport of the interfacial charges.

• The FeIn2S4/CdS exhibited 14.5-fold higher photocurrent than single FeIn2S4.

• Label-free PEC aptasensors show the higher sensitivity, faster analysis, and weaker interference than traditional techniques.

• The PEC aptasensor exhibited a wider linear range with a lower limit of detection for KAN.

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Xin, FF., Song, P., Fang, KM. et al. Label-free “signal-off” PEC aptasensor for determination of kanamycin based on 3D nanoflower-like FeIn2S4/CdS Z-scheme heterostructures. Microchim Acta 190, 351 (2023). https://doi.org/10.1007/s00604-023-05942-5

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