Abstract
A near-infrared (NIR) fluorescence nanoprobe named RhI-DOX@ZIF-90 has been synthesized by wrapping the guest molecule (RhI and DOX) into ZIF-90 framework. The nanoprobe itself is non-fluorescent and the drug (DOX) is inactive. Upon the addition of ATP, the structure of RhI-DOX@ZIF-90 is degraded. The fluorescence of RhI is recovered and DOX is released. The nanoprobe can detect ATP with high sensitivity and selectivity. There is good linear relationship between the nanoprobe and ATP concentration from 0.25 to 10 mM and the detection limit is 0.10 mM. The nanoprobe has the ability to monitor the change of ATP level in living cells and DOX is released inducing apoptosis of cancer cells. RhI-DOX@ZIF-90 is capable of targeting mitochondria, which provides a basis for improving the efficiency of drug delivery by mitochondrial administration. In particular, the nanoprobe is preferentially accumulated in the tumor sites and detect ATP in tumor mice by fluorescence imaging using near-infrared fluorescence. At the same time, DOX can be released accurately in tumor sites and have good anti-tumor efficiency. So, this nanoprobe is a reliable tool to realize early diagnosis of cancer and improve effect of anticancer drug.
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Funding
This work was supported by the National Natural Science Foundation of China (21775133), Scientific Research Fund of Hunan Provincial Education Department (19A479), Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University (2020YB01), Key Project of Science and Technology of Henan Province (202102310215), the Degree & Postgraduate Education Reform Project of Hunan Province (2019JGYB113), and Hunan Provincial Innovation Foundation For Postgraduate (CX20190483, CX20200635).
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Chen, XX., Hou, MJ., Mao, GJ. et al. ATP-responsive near-infrared fluorescence MOF nanoprobe for the controlled release of anticancer drug. Microchim Acta 188, 287 (2021). https://doi.org/10.1007/s00604-021-04953-4
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DOI: https://doi.org/10.1007/s00604-021-04953-4