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Sensitive sandwich-type voltammetric immunosensor for breast cancer biomarker HER2 detection based on gold nanoparticles decorated Cu-MOF and Cu2ZnSnS4 NPs/Pt/g-C3N4 composite

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Abstract

A sandwich-type sensitive voltammetric immunosensor for breast cancer biomarker human epidermal growth factor receptor 2 (HER2) detection was prepared. The electrochemical immunosensor was developed based on gold nanoparticles decorated copper-organic framework (AuNPs/Cu-MOF) and quaternary chalcogenide with platinum-doped graphitic carbon nitride (g-C3N4). Cu2ZnSnS4 nanoparticle (CZTS NP) quaternary chalcogenide with platinum (Pt)-doped g-C3N4 composite (Pt/g-C3N4) was tagged as CZTS NPs/Pt/g-C3N4. AuNPs/Cu-MOF composite was successfully synthesized by amidation reaction between AuNPs functionalized with amino group and Cu-MOFs containing carboxylic acid. After the conjugations of primer HER2 antibody and antigen HER2 protein to AuNPs/Cu-MOF as sensor platform, CZTS NPs/Pt/g-C3N4 composite was prepared by one-pot hydrothermal method. After immune reaction of 30 min, the prepared HER2 immunosensor was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), x-ray diffraction (XRD) method, x-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The developed immunosensor showed high sensitivity with a detection limit of 3.00 fg mL−1. Additional properties of the voltammetric immunosensor are high selectivity, stability, reproducibility, and reusability.

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Acknowledgements

Mehmet Lütfi YOLA would like to thank Turkish Academy of Sciences (TUBA- GEBIP) for their invaluable support.

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  1. Faculty of Health Sciences, Department of Nutrition and Dietetics, Hasan Kalyoncu University, Gaziantep, Turkey

    Mehmet Lütfi Yola

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Yola, M.L. Sensitive sandwich-type voltammetric immunosensor for breast cancer biomarker HER2 detection based on gold nanoparticles decorated Cu-MOF and Cu2ZnSnS4 NPs/Pt/g-C3N4 composite. Microchim Acta 188, 78 (2021). https://doi.org/10.1007/s00604-021-04735-y

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