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Simultaneous electrochemical determination of nitrofurantoin and nifedipine with assistance of needle-shaped perovskite structure: barium stannate fabricated glassy carbon electrode

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Abstract

A needle-shaped perovskite, barium stannate (BaSnO3), was synthesized via a co-precipitation technique for the simultaneous electrochemical determination of antibiotic drug nitrofurantoin (NFTO) and pericardial drug nifedipine (NFP). The spectroscopic and microscopic result confirms that as-prepared BaSnO3 particles formed with desired crystalline nature, functional group, pore size, pore diameter, and fine needle-like morphology. The simultaneous electrochemical detection of the two pharmaceutical compounds was examined via cyclic voltammetry (CV) and differential pulse voltammetry (DPV) technique using BaSnO3-modified glassy carbon electrode (BaSnO3/GCE) at a potential range from +0.4 to − 1.2 V. The discrete and simultaneous detection of NFTO and NFP at the BaSnO3 sensor exhibits higher catalytic activity in terms of cathodic current and cathodic potential compared to bare GCE. DPV results of the BaSnO3 sensor provide improved linear ranges and limits of detection for NFTO (0.01–42.65 µM; 42.65–557.65 μM, 0.062 μM, respectively) and NFP (0.01–697.65 μM, 0.0168 μM, respectively). Besides, the BaSnO3-fabricated sensor exhibits good sensitivity, reproducibility, and repeatability. The modified electrode shows excellent recoveries of NFTO (97.0–100.7%) and NFP (98.7–101.3%) in plasma, urine, and milk samples with an acceptable relative standard deviation (RSD) of 1.6–4.8%.

Needle-shaped BaSnO3 perovskite material for simultaneous electrochemical sensing of pharmaceutical drugs.

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Funding

This project was supported by the Ministry of Science and Technology (MOST 107-2113-M-027-005-MY3), Taiwan. This work is also jointly supported by the projects from NTUT-NUST-109-01 and NSFC51872141, National Taipei University of Technology, and Nanjing University of Science and Technology.

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Authors and Affiliations

  1. Electroanalysis and Bioelectrochemistry Laboratory, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei, 106, Taiwan, Republic of China

    Muthukutty Balamurugan, Krishnapandi Alagumalai & Shen-Ming Chen

  2. Department of Materials, Imperial College London, London, SW7 2AZ, UK

    Tse-Wei Chen

  3. Key Laboratory of Education Ministry for Soft Chemistry and Functional Materials, Nanjing University of Science and Technology, Nanjing, 210094, China

    Xiaoheng Liu

  4. Department of Chemistry, ACS College of Engineering, Bengaluru, Karnataka, 560074, India

    Muthusamy Selvaganapathy

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  1. Muthukutty Balamurugan
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  2. Krishnapandi Alagumalai
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  3. Tse-Wei Chen
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  4. Shen-Ming Chen
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Correspondence to Shen-Ming Chen or Xiaoheng Liu.

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Balamurugan, M., Alagumalai, K., Chen, TW. et al. Simultaneous electrochemical determination of nitrofurantoin and nifedipine with assistance of needle-shaped perovskite structure: barium stannate fabricated glassy carbon electrode. Microchim Acta 188, 19 (2021). https://doi.org/10.1007/s00604-020-04645-5

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