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Core-shell hollow spheres of type C@MoS2 for use in surface-assisted laser desorption/ionization time of flight mass spectrometry of small molecules

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Abstract

Mesoporous carbon hollow spheres coated with MoS2 (C@MoS2) were synthesized to obtain a material with large specific surface area, fast electron transfer efficiency and good water dispersibility. The composite material was applied as a matrix for the analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). The use of a core-shell C@MoS2 matrix strongly reduces matrix background interferences and increases signal intensity in the analysis of sulfonamides antibiotics (SAs), cationic dyes, emodin, as well as estrogen and amino acids. The composite material was applied to the SALDI-TOF MS analysis of selected molecules in (spiked) real samples. The ionization mechanism of the core-shell C@MoS2 as a matrix is discussed. The method exhibits low fragmentation interference, excellent ionization efficiency, high reproducibility and satisfactory salt tolerance.

Schematic representation of the method for fabrication of MoS2-coated mesoporous carbon hollow spheres (core-shell C@MoS2). As a new matrix, the nanocomposites were applied to analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry.

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Acknowledgements

This work was supported by The National Key Research and Development Program of China (2018YFC1603500), Natural Science Foundation of Shandong Province (ZR2017MB011), Key R&D Program of Shandong Province (2019GSF111009, 2019GSF111001), Key Laboratory of Biomedical Effects of Nanomaterials and Nanosafety, CAS(NSKF201813), the Special Grant for High-Level Overseas Talents of Shandong Academy of Sciences, Youth Science Funds of Shandong Academy of Sciences (2019QN008,2019QN009).

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Authors and Affiliations

  1. Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province, Shandong Analysis and Test Centre, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250014, China

    Yanfang Zhao, Hanyi Xie, Mei Zhao, Huijuan Li & Xiangfeng Chen

  2. State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, 999077, People’s Republic of China

    Zongwei Cai

  3. Intelligene Biosystems (QingDao) Co. Ltd., Qingdao, 266400, China

    Hexing Song

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  1. Yanfang Zhao
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Correspondence to Xiangfeng Chen.

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Zhao, Y., Xie, H., Zhao, M. et al. Core-shell hollow spheres of type C@MoS2 for use in surface-assisted laser desorption/ionization time of flight mass spectrometry of small molecules. Microchim Acta 186, 830 (2019). https://doi.org/10.1007/s00604-019-3960-1

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