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Cobalt-doped nanoporous carbon as SALDI-TOF-MS adsorbent and matrix for quantification of cetyltrimethylammonium bromide, Rhodamine B and Malachite Green at sub-ppt levels

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Abstract

Cobalt-doped nanoporous carbon (Co-NPC) with dodecahedral shape was pyrolytically synthesized and applied as a sorbent and matrix for the enrichment and analysis of small molecules by surface-assisted laser desorption/ionization time-of-flight mass spectrometry (SALDI-TOF MS). Extremely low detection limits were accomplished for cetyltrimethylammonium bromide (1 fg·mL−1), and Rhodamine B (1 fg·mL−1) in water, and Malachite Green and its metabolite in fish blood and fish extracts (pg·mL−1 concentrations).

Schematic representation of cobalt-doped nanoporous carbons (Co-NPCs) applied as SALDI matrix for analysis of toxic contaminants in fish and receipt papers. The Co-NPCs have a high desorption/ionization efficiency and low limit of detection.

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Acknowledgements

This work was supported by a grant from National Natural Science Foundation of China (21874038).

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Authors and Affiliations

  1. State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People’s Republic of China

    Deshuai Zhen, Ning Jiang, Hongchao Geng, Yan Qiao, Yu Liu, Xingqi Zhu, Chan Gao & Qingyun Cai

  2. College of Chemistry and Chemical Engineering, Qiannan Normal University for Nationalities, Duyun, 558000, People’s Republic of China

    Deshuai Zhen

  3. Flux Photon Corporation, 5950 Shiloh Road East, Alpharetta, GA, 30005, USA

    Craig A. Grimes

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  1. Deshuai Zhen
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  2. Ning Jiang
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  4. Yan Qiao
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  5. Yu Liu
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Correspondence to Qingyun Cai.

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Zhen, D., Jiang, N., Geng, H. et al. Cobalt-doped nanoporous carbon as SALDI-TOF-MS adsorbent and matrix for quantification of cetyltrimethylammonium bromide, Rhodamine B and Malachite Green at sub-ppt levels. Microchim Acta 186, 691 (2019). https://doi.org/10.1007/s00604-019-3816-8

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