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A glassy carbon electrode modified with porous Cu2O nanospheres on reduced graphene oxide support for simultaneous sensing of uric acid and dopamine with high selectivity over ascorbic acid

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Abstract

Porous cuprous oxide nanospheres were deposited on reduced graphene oxide (pCu2O NS-rGO) by a solvothermal approach that uses hexadecyltrimethylammonium bromide as the capping agent and L-glutamic acid as the reducing agent. The nanomaterial was characterized by transmission electron microscopy, Raman spectroscopy, thermogravimetry, and electrochemical methods. A glassy carbon electrode was modified with pCu2O NS-rGO, and the respective electrode displays a well expressed oxidation peak for dopamine (DA) located at 160 mV (vs. SCE). It also gives a strong peak for uric acid (UA) which is separated from the DA peak by 130 mV (vs. SCE). No signals can be detected for ascorbic acid (AA) in concentrations up to 2.0 mM. The findings are exploited in a method for simultaneous determination of UA and DA. The linear ranges are from 1.0 to 138 μM for UA, and from 0.05 to 109 μM for DA even in the presence of relatively high concentrations of AA. The detection limits are 112 nM for UA and 15 nM for DA (at an S/N ratio of 3).

Porous cuprous oxide nanospheres deposited on reduced graphene oxide was fabricated by a one-pot solvothermal method. The nanocomposites were explored to construct a sensor for simultaneous determination of uric acid and dopamine in the presence of ascorbic acid with high concentration.

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Acknowledgment

This work was financially supported by National Natural Science Foundation of China (Nos. 21475118, 21275130, 21275131, 21505121 and 21506195).

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Authors and Affiliations

  1. College of Geography and Environmental Science, College of Chemistry and Life Science, Zhejiang Normal University, Jinhua, 321004, China

    Li-Ping Mei, Jiu-Ju Feng, Liang Wu, Jian-Rong Chen, Liguo Shen, Yunlong Xie & Ai-Jun Wang

  2. Xingzhi College, Zhejiang Normal University, Jinhua, 321004, China

    Yunlong Xie

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  1. Li-Ping Mei
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  2. Jiu-Ju Feng
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  3. Liang Wu
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Correspondence to Yunlong Xie or Ai-Jun Wang.

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Mei, LP., Feng, JJ., Wu, L. et al. A glassy carbon electrode modified with porous Cu2O nanospheres on reduced graphene oxide support for simultaneous sensing of uric acid and dopamine with high selectivity over ascorbic acid. Microchim Acta 183, 2039–2046 (2016). https://doi.org/10.1007/s00604-016-1845-0

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