Abstract
To reveal the shear-seepage coupling characteristics of fractured specimens under cyclic loading and unloading, the specific test device and test method were designed in this study. The cyclic loading and unloading shear-seepage coupling test on the fractured rock mass under different confining pressures and seepage pressures was carried out by processing “double L-shaped” specimens, and the change laws of the shear characteristics and seepage characteristics of fractured specimens with different roughness were experimentally investigated. The results indicated that the peak shear stress, residual shear stress, and shear stiffness of rough fractures all increase with increasing confining pressure, while the change in normal dilatation displacement is the opposite. Under a constant normal stress, the permeability of rough fracture decreases, increase, and then stabilizes with increasing shear displacement. The peak shear stress of the smooth fracture is 3.7 times lower than that of the rough fracture with the same shear displacement, and the smooth sandstone specimens are all in a shear shrinkage state, with the normal shrinkage displacement of less than 1.0 mm. In addition, during unloading, permeability increases to some extent but cannot recover to the original value. The confining pressure causes permanent damage to the permeability of fractured rock mass. The permeability of sandstone specimens changes primarily in the early loading stage and late unloading stage. Based on the test results, the relationship between permeability and confining pressure follows a negative exponential function under cyclic loading and unloading conditions.
Highlights
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The shear-seepage coupling test device and test method were designed.
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The effect of seepage pressure on the hydro-mechanical coupling of rough fractures has a threshold value.
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The permeability of rough fractured specimen changes in the staged manner of “decrease-increase-stability” with increasing shear displacement.
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The initial stage of loading and the later stage of unloading are the main stages of permeability change of fractured sandstone specimens.
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References
Aalianvari A (2017) Combination of engineering geological data and numerical modeling results to classify the tunnel route based on the groundwater seepage. Geomech Eng 13(4):671–683. https://doi.org/10.12989/gae.2017.13.4.671
Abierdi XYZ, Zhong HY, Gu X, Liu HL, Zhang WG (2020) Laboratory model tests and DEM simulations of unloading-induced tunnel failure mechanism. CMC-Comput Mater Con 63(2):825–844. https://doi.org/10.3264/cmc.2020.07946
Ahola MP, Mohanty S, Makurat A (1996) Coupled mechanical shear and hydraulic flow behavior of natural rock joints. Dev Geotech Eng 79(C):393–423. https://doi.org/10.1016/S0165-1250(96)80034-4
Boulon MJ, Selvadurai APS, Benjelloun H, Feuga B (1993) Influence of rock joint degradation on hydraulic conductivity. Int J Rock Mech Min Sci Geomech Abstr 30(7):1311–1317. https://doi.org/10.1016/0148-9062(93)90115-T
Cao C, Xu ZG, Chai JR, Qin Y, Tan R (2018) Mechanical and hydraulic behaviors in a single fracture with asperities crushed during shear. Int J Geomech 18(11):04018148. https://doi.org/10.1061/(ASCE)GM.1943-5622.0001277
Cappa F, Guglielmi Y, Rutqvist J, Tsang CF, Thoraval A (2005) Hydromechanical interactions in a fractured carbonate reservoir inferred from hydraulic and mechanical measurements. Int J Rock Mech Min 42(2):287–306. https://doi.org/10.1016/j.ijrmms.2004.11.006
Cappa F, Guglielmi Y, Rutqvist J, Tsang CF, Thoraval A (2006) Hydromechanical modelling of pulse tests that measure fluid pressure and fracture normal displacement at the Coaraze laboratory site. France Int J Rock Mech Min 43(7):1062–1082. https://doi.org/10.1016/j.ijrmms.2006.03.006
Chao ZM, Ma GT, Hu XW, He K, Luo G, Mei XF, Li D (2020) Experimental research on stress-dependent permeability and porosity of rock-like materials with different thicknesses of smooth hidden joints. Int J Mod Phys B 34(12):2050117. https://doi.org/10.1142/S0217979220501179
Chen Z, Narayan SP, Yang Z, Rahman SS (2000) An experimental investigation of hydraulic behaviour of fractures and joints in granitic rock. Int J Rock Mech Min 37(7):1061–1071. https://doi.org/10.1016/S1365-1609(00)00039-3
Chen HM, Zhao ZY, Choo LQ, Sun JP (2016) Rock cavern stability analysis under different hydro-geological conditions using the coupled hydro-mechanical model. Rock Mech Rock Eng 49(2):555–572. https://doi.org/10.1007/s00603-015-0748-4
Chen SJ, Feng F, Wang YJ, Li DY, Huang WP, Zhao XD, Jiang N (2020) Tunnel failure in hard rock with multiple weak planes due to excavation unloading of in-situ stress. J Cent South Univ 27(10):2864–2882. https://doi.org/10.1007/s11771-020-4515-7
Di ST, Jia C, Qiao WG, Yu WJ, Li K (2017) Theoretical and experimental investigation of characteristics of single fracture stress-seepage coupling considering microroughness. Math Probl Eng. https://doi.org/10.1155/2017/6431690
Duan K, Ji YL, Wu W, Kwok CY (2019) Unloading-induced failure of brittle rock and implications for excavation induced strain burst. Tunn Undergr Sp Tech 84(2):495–506. https://doi.org/10.1016/j.tust.2018.11.012
Eggertsson GH, Lavallee Y, Kendrick JE, Markusson SH (2020) Improving fluid flow in geothermal reservoirs by thermal and mechanical stimulation: the case of Krafla volcano. Iceland J Volcanol Geoth Res 391:106351. https://doi.org/10.1016/j.jvolgeores.2018.04.008
Esaki T, Du S, Mitani Y, Ikusada K, Jing L (1999) Development of a shear-flow test apparatus and determination of coupled properties for a single rock joint. Int J Rock Mech Min 36(5):641–650. https://doi.org/10.1016/S0148-9062(99)00044-3
Faoro I, Vinciguerra S, Marone C, Elsworth D, Schubnel A (2013) Linking permeability to crack density evolution in thermally stressed rocks under cyclic loading. Geophys Res Lett 40(11):2590–2595. https://doi.org/10.1002/grl.50436
Feng F, Chen SJ, Li DY, Huang WP, Peng K, Zang CW (2020) Excavation unloading-induced fracturing of hard rock containing different shapes of central holes affected by unloading rates and in situ stresses. Energy Sci Eng 8(1):4–27. https://doi.org/10.1002/ese3.486
Fu CH, Xie HP, Gao MZ, Wang F, Xie J, Liu JJ, Yang BG, Tang RF (2021) Mechanical behaviour and seepage characteristics of coal under the loading path of roadway excavation and coal mining. Geomat Nat Haz Risk 12(1):1862–1884. https://doi.org/10.1080/19475705.2021.1948451
Gramiger LM, Moore JR, Gischig VS, Loew S, Funk M, Limpach P (2020) Hydromechanical rock slope damage during late pleistocene and holocene glacial cycles in an alpine valley. J Geophys Res-Earth. https://doi.org/10.1029/2019JF005494
Gui Y, Xia CC, Ding WQ, Qian X, Du SG (2017) A new method for 3D modeling of joint surface degradation and void space evolution under normal and shear loads. Rock Mech Rock Eng 50(10):2827–2836. https://doi.org/10.1007/s00603-017-1242-y
Guo JQ, Qian Y, Chen JX, Chen F (2019) The minimum safe thickness and catastrophe process for water inrush of a karst tunnel face with multi fractures. Processes 7(10):686. https://doi.org/10.3390/pr7100686
He XP, Sinan M, Kwak H, Hoteit H (2021) A corrected cubic law for single-phase laminar flow through rough-walled fractures. Adv Water Resour 154:103984. https://doi.org/10.1016/j.advwatres.2021.103984
Huang N, Jiang YJ, Liu RC, Li B, Zhang ZY (2017) A predictive model of permeability for fractal-based rough rock fractures during shear. Fractals 25(5):1750051. https://doi.org/10.1142/S0218348X17500517
Huang MQ, Zhang L, Zhang C, Cheng S (2020) Characteristics of permeability changes in bituminous coal under conditions of stress variation due to repeated mining activities. Nat Resour Res 29(3):1687–1704. https://doi.org/10.1007/s11053-019-09542-0
Jang HS, Kang SS, Jang BA (2014) Determination of joint roughness coefficients using roughness parameters. Rock Mech Rock Eng 47(6):2061–2073. https://doi.org/10.1007/s00603-013-0535-z
Javadi M, Sharifzadeh M, Shahriar K, Mitani Y (2014) Critical reynolds number for nonlinear flow through rough-walled fractures: the role of shear processes. Water Resour Res 50(2):1789–1804. https://doi.org/10.1002/2013WR014610
Jia P, Yang N, Liu DQ (2021) Effect of unloading direction on rock failure under true triaxial stress conditions. J Test Eval 49(6):4058–4071. https://doi.org/10.1520/JTE20200298
Jiang Q, Zhang MZ, Yan F, Su GS, Feng XT, Xu DP, Feng GL (2020) Effect of initial minimum principal stress and unloading rate on the spalling and rockburst of marble: a true triaxial experiment investigation. B Eng Geol Environ 80(2):1617–1634. https://doi.org/10.1007/s10064-020-01995-5
Kling T, Huo D, Schwarz JO, Enzmann F, Benson S, Blum P (2016) Simulating stress-dependent fluid flow in a fractured core sample using real-time X-ray CT data. Solid Earth 7(4):1109–1124. https://doi.org/10.5194/se-7-1109-2016
Kong HL, Yin MG, Wang LZ, Zhang HL, Ji F (2021) A review of the mass-loss-induced non-Darcy seepage and seepage suffosion in the fractured zone: the concepts discrimination and connection. Arab J Geosci 14(23):2522. https://doi.org/10.1007/s12517-021-08754-0
Koyama T, Li B, Jiang Y, Jing L (2009) Numerical modelling of fluid flow tests in a rock fracture with a special algorithm for contact areas. Comput Geotech 36(1–2):291–303. https://doi.org/10.1016/j.compgeo.2008.02.010
Lee HS, Cho TF (2002) Hydraulic characteristics of rough fractures in linear flow under normal and shear load. Rock Mech Rock Eng 35(4):299–318. https://doi.org/10.1007/s00603-002-0028-y
Li XB, Du K, Li DY (2015) True triaxial strength and failure modes of cubic rock specimens with unloading the minor principal stress. Rock Mech Rock Eng 48(6):2185–2196. https://doi.org/10.1007/s00603-014-0701-y
Li B, Liu RC, Jiang YJ (2019) An experimental method to visualize shear-induced channelization of fluid flow in a rough-walled fracture. Hydrogeol J 27(8):3097–3106. https://doi.org/10.1007/s10040-019-02048-2
Li LP, Tu WF, Zhou ZQ, Shi SH, Zhang MG, Chen YX (2020) Dynamic unloading instability mechanism of underground cavern based on seepage-damage coupling. KSCE J Civ Eng 24(5):1620–1631. https://doi.org/10.1007/s12205-020-1288-3
Li JB, Wang YH, Tan ZS, Du W, Liu ZY (2021) Study on water inflow variation law of no.1 shaft auxiliary shaft in highligongshan based on dual medium model. Symmetry-Basel 13(6):930. https://doi.org/10.3390/sym13060930
Liu W, Chen YF, Hu R, Zhou W, Zhou CB (2016) A two-step homogenization-based permeability model for deformable fractured rocks with consideration of coupled damage and friction effects. Int J Rock Mech Min 89:212–226. https://doi.org/10.1016/j.ijrmms.2016.09.009
Liu C, Yu BC, Zhang DM, Zhao HG (2020a) Experimental study on strain behavior and permeability evolution of sandstone under constant amplitude cyclic loading-unloading. Energy Sci Eng. https://doi.org/10.1002/ese3.527
Liu RC, Huang N, Jiang YJ, Han GS, Jing HW (2020b) Effect of shear direction change on shear-flow-transport processes in single rough-walled rock fractures. Transport Porous Med 133(3):373–395. https://doi.org/10.1007/s11242-020-01428-7
Liu J, Li ZP, Zhang X, Weng XJ (2021) Analysis of water and mud inrush in tunnel fault fracture zone-a case study of Yonglian tunnel. Sustainability-Basel 13(17):9585. https://doi.org/10.3390/su13179585
Ma YQ, Zhang YJ, Huang YB, Zhang Y, Hu ZJ (2019) Experimental study on flow and heat transfer characteristics of water flowing through a rock fracture induced by hydraulic fracturing for an enhanced geothermal system. Appl Therm Eng 154:433–441. https://doi.org/10.1016/j.applthermaleng.2019.03.114
Meng QB, Zhang MW, Han LJ, Pu H, Nie TY (2016) Effects of acoustic emission and energy evolution of rock specimens under the uniaxial cyclic loading and unloading compression. Rock Mech Rock Eng 49(10):3873–3886. https://doi.org/10.1007/s00603-016-1077-y
Meng QB, Zhang MW, Han LJ, Pu H, Chen YL (2018) Acoustic emission characteristics of red sandstone specimens under uniaxial cyclic loading and unloading compression. Rock Mech Rock Eng 51(4):969–988. https://doi.org/10.1007/s00603-017-1389-6
Mofakham AA, Stadelman M, Ahmadi G, Shanley KT, Crandall D (2018) Computational modeling of hydraulic properties of a sheared single rock fracture. Transport Porous Med 124(1):1–30. https://doi.org/10.1007/s11242-018-1030-5
Nishiyama S, Ohnishi Y, Ito H, Yano T (2014) Mechanical and hydraulic behavior of a rock fracture under shear deformation. Earth Planets Space 66:108. https://doi.org/10.1186/1880-5981-66-108
Olsson R, Barton N (2001) An improved model for hydromechanical coupling during shearing of rock joints. Int J Rock Mech Min 38(3):317–329. https://doi.org/10.1016/S1365-1609(00)00079-4
Park H, Osada M, Matsushita T, Takahashi M, Ito K (2013) Development of coupled shear-flow-visualization apparatus and data analysis. Int J Rock Mech Min 63:72–81. https://doi.org/10.1016/j.ijrmms.2013.06.003
Peguiron F, Labiouse V (2020) Consideration of anisotropies related to bedding planes in the modelling of thick-walled hollow cylinder tests on boom clay. Eur J Environ Civ En. https://doi.org/10.1080/19648189.2020.1830178
Qian X, Xia CC, Gui Y (2018) Quantitative estimates of non-darcy groundwater flow properties and normalized hydraulic aperture through discrete open rough-walled joints. Int J Geomech 18(9):04018099. https://doi.org/10.1061/(ASCE)GM.1943-5622.0001228
Qiu SL, Feng XT, Xiao JQ, Zhang CQ (2014) An experimental study on the pre-peak unloading damage evolution of marble. Rock Mech Rock Eng 47(2):401–419. https://doi.org/10.1007/s00603-013-0394-7
Ren JX, Chen X, Chen XZ, Yun MC, Cao XT, Liu TT (2020) Effect of porewater pressure on the mechanical properties of red sandstone with different unloading rates. Q J Eng Geol Hydroge. https://doi.org/10.1144/qjegh2019-101
Rong G, Yang J, Cheng L, Zhou CB (2016) Laboratory investigation of nonlinear flow characteristics in rough fractures during shear process. J Hydrol 541:1385–1394. https://doi.org/10.1016/j.jhydrol.2016.08.043
Rong G, Yang J, Cheng L, Tan J, Peng J, Zhou CB (2018) A forchheimer equation-based flow model for fluid flow through rock fracture during shear. Rock Mech Rock Eng 51(9):2777–2790. https://doi.org/10.1007/s00603-018-1497-y
Sathar S, Reeves HJ, Cuss RJ, Harrington JF (2012) The role of stress history on the flow of fluids through fractures. Mineral Mag 76(8):3165–3177. https://doi.org/10.1180/minmag.2012.076.8.30
Shen N, Li XC, Zhang Q, Wang L (2021) Comparison of shear-induced gas transmissivity of tensile fractures in sandstone and shale under varying effective normal stresses. J Nat Gas Sci Eng 95:104218. https://doi.org/10.1016/j.jngse.2021.104218
Sun WB, Xue YC, Yin LM, Zhang JM (2019) Experimental study on seepage characteristics of large size rock specimens under three-dimensional stress. Geomech Eng 18(6):567–574. https://doi.org/10.12989/gae.2019.18.6.567
Tian ZX, Dai CQ, Zhao QS, Meng ZB, Zhang BL (2021) Experimental study of join roughness influence on fractured rock mass seepage. Geofluids. https://doi.org/10.1155/2021/8813743
Tse R, Cruden DM (1979) Estimating joint roughness coefficients. Int J Rock Mech Min Sci Geomech Abstr 16(5):303–307. https://doi.org/10.1016/0148-9062(79)90241-9
Vazaios I, Vlachopoulos N, Diederichs MS (2019) Assessing fracturing mechanisms and evolution of excavation damaged zone of tunnels in interlocked rock masses at high stresses using a finite-discrete element approach. J Rock Mech Geotech Eng 11(4):701–722. https://doi.org/10.1016/j.jrmge.2019.02.004
Vogler D, Amann F, Bayer P, Elsworth D (2016) Permeability evolution in natural fractures subject to cyclic loading and gouge formation. Rock Mech Rock Eng 49(9):3463–3479. https://doi.org/10.1007/s00603-016-1022-0
Wang CS, Jiang YJ, Liu RC, Wang C, Zhang ZY, Sugimoto S (2020a) Experimental study of the nonlinear flow characteristics of fluid in 3d rough-walled fractures during shear process. Rock Mech Rock Eng 53(6):2581–2604. https://doi.org/10.1007/s00603-020-02068-5
Wang M, Guo QF, Shan PF, Cai MF, Ren FH, Dai B (2020b) Numerical research of fluid flow and solute transport in rough fractures under different normal stress. Geofluids 3:1–17. https://doi.org/10.1155/2020/8845216
Wu ZJ, Fan LF, Zhao SH (2018) Effects of hydraulic gradient, intersecting angle, aperture, and fracture length on the nonlinearity of fluid flow in smooth intersecting fractures: an experimental investigation. Geofluids. https://doi.org/10.1155/2018/9352608
Xiang YZ, Zeng ZK, Xiang YJ, Abi E, Zheng YR, Yuan HC (2021) Tunnel failure mechanism during loading and unloading processes through physical model testing and DEM simulation. Sci Rep-UK 11(1):16753. https://doi.org/10.1038/s41598-021-96206-w
Xiong XB, Li B, Jiang YJ, Koyama T, Zhang CH (2011) Experimental and numerical study of the geometrical and hydraulic characteristics of a single rock fracture during shear. Int J Rock Mech Min 48(8):1292–1302. https://doi.org/10.1016/j.ijrmms.2011.09.009
Xue Y, Liu Y, Dang FN, Liu J, Ma ZY, Zhu L, Yang HW (2019) Assessment of the nonlinear flow characteristic of water inrush based on the brinkman and forchheimer seepage model. Water-Sui 11(4):855. https://doi.org/10.3390/w11040855
Yang TJ, Wang SH, Wang PY, Zhang Z (2021) Hydraulic and mechanical coupling analysis of rough fracture network under normal stress and shear stress. KSCE J Civ Eng. https://doi.org/10.1007/s12205-021-0660-2
Yeo IW, De Freitas MH, Zimmerman RW (1998) Effect of shear displacement on the aperture and permeability of a rock fracture. Int J Rock Mech Min 35(8):1051–1070. https://doi.org/10.1016/S0148-9062(98)00165-X
Yin Q, Ma GW, Jing HW, Wang HD, Su HJ, Wang YC, Liu RC (2017) Hydraulic properties of 3D rough-walled fractures during shearing: an experimental study. J Hydrol 555:169–184. https://doi.org/10.1016/j.jhydrol.2017.10.019
Zhang C, Zhang L, Zhao YX, Wang W (2018) Experimental study of stress-permeability behavior of single persistent fractured coal samples in the fractured zone. J Geophys Eng 15(5):2159. https://doi.org/10.1088/1742-2140/aac12e
Zhang X, Chai JR, Qin Y, Cao J, Cao C (2019) Experimental study on seepage and stress of single-fracture radiation flow. KSCE J Civ Eng 23(3):1132–1140. https://doi.org/10.1007/s12205-019-1519-7
Zhang T, Liu Y, Yang K, Tang M, Yu X, Yu F (2020) Hydromechanical coupling characteristics of the fractured sandstone under cyclic loading-unloading. Geofluids 2:1–12. https://doi.org/10.1155/2020/8811003
Zhang HW, Wan ZJ, Zhao YX, Zhang Y, Chen YL, Wang JH, Cheng JY (2021a) Shear induced seepage and heat transfer evolution in a single-fractured hot-dry-rock. Cmes-Comp Model Eng 126(2):443–455. https://doi.org/10.32604/cmes.2021a.013179
Zhang L, Huang MQ, Li MX, Lu S, Yuan XC, Li JH (2021b) Experimental study on evolution of fracture network and permeability characteristics of bituminous coal under repeated mining effect. Nat Resour Res. https://doi.org/10.1007/s11053-021-09971-w
Zhang T, Xu WY, Wang HL, Wang RB, Yan L, Hu MT (2021c) Anisotropic mechanical behaviour of columnar jointed rock masses subjected to cyclic loading: an experimental investigation. Int J Rock Mech Min 148:104954. https://doi.org/10.1016/j.ijrmms.2021.104954
Zhao LH, Zhang SH, Huang DL, Zuo S, Li DJ (2018) Quantitative characterization of joint roughness based on semivariogram parameters. Int J Rock Mech Min 109:1–8. https://doi.org/10.1016/j.ijrmms.2018.06.008
Zhao K, Wang QZ, Chen Q, Zhuang HY, Chen GX (2021a) Simplified effective stress modeling of shear wave propagation in saturated granular soils. Geotech Lett 11(1):1–9. https://doi.org/10.1680/jgele.19.00023
Zhao Y, Bi J, Wang CL, Liu P (2021b) Effect of unloading rate on the mechanical behavior and fracture characteristics of sandstones under complex triaxial stress conditions. Rock Mech Rock Eng 54(9):4851–4866. https://doi.org/10.1007/s00603-021-02515-x
Zhao K, Wang QZ, Zhuang HY, Li ZY, Chen GX (2022) A fully coupled flow deformation model for seismic site response analyses of liquefiable marine sediments. Ocean Eng 251:111144. https://doi.org/10.1016/j.oceaneng.2022.111144
Zhou XP, Shou YD (2013) Excavation-induced zonal disintegration of the surrounding rock around a deep circular tunnel considering unloading effect. Int J Rock Mech Min 64:246–257. https://doi.org/10.1016/j.ijrmms.2013.08.010
Zhu GA, Dou LM, Wang CB, Ding ZW, Feng ZJ, Xue F (2019) Experimental study of rock burst in coal samples under overstress and true-triaxial unloading through passive velocity tomography. Safety Sci 117:388–403. https://doi.org/10.1016/j.ssci.2019.04.012
Acknowledgements
This work was supported by the National Natural Science Foundation of China (Grant No.U1602232), the Liaoning Province Science and technology plan, China (2019JH2-10100035), the Fundamental Research Funds for the Central Universities (N170108029), the fundamental research funds for the central universities (Grant No.2101018), Study on dynamic characterization method and catastrophe criterion of surrounding rock damage under large-scale mining in deep multi-mining area (SMDPC202103) and the China Scholarship Council (CSC No.201906080071) for a joint Ph.D. fellowship, which enabled Tianjiao Yang to visit the Environmental Geomechanics Laboratory, the Department of Civil Engineering and Applied Mechanics, McGill University, Canada.
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TY: conceptualization, methodology, experiment, software, visualization, writing—original draft. PW: data curation, experiment, investigation, writing—review and editing, funding acquisition. SW: supervision, formal analysis, funding acquisition. HL: experiment, writing—review and editing. ZZ: experiment, writing—review and editing.
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Yang, T., Wang, P., Wang, S. et al. Experimental Study on Shear-Seepage Coupling Characteristics of Single Fractured Rock Mass Under Cyclic Loading and Unloading. Rock Mech Rock Eng 56, 2137–2156 (2023). https://doi.org/10.1007/s00603-022-03125-x
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DOI: https://doi.org/10.1007/s00603-022-03125-x