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The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection

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Abstract

Purpose

The significance of the duration of the recurrence-free survival after curative resection for colorectal cancer remains unclear. The purpose was to reveal the association between time to recurrence after surgery and the survival after recurrence.

Methods

Patients with stage II and III colorectal cancer who underwent curative resection between 2007 and 2015 were retrospectively reviewed (n = 645). Patients with recurrence after surgery (n = 133) were divided into 2 groups: early recurrence (within 13 months after surgery, n = 63) and late recurrence (more than 13 months after surgery, n = 70). The overall survival after recurrence and clinicopathological features were compared between early recurrence, late recurrence, and without recurrence groups.

Results

The overall survival after recurrence was significantly shorter in patients with early recurrence occurring at less than 13 months (hazard ratio: 1.70, p = 0.03). A high preoperative CA19-9 level (odds ratio [OR]: 2.38, p = 0.03), venous invasion (OR: 2.26, p = 0.03), and the absence of adjuvant chemotherapy (OR: 2.08, p = 0.04) were independently correlated with early recurrence.

Conclusion

Early recurrence was associated with a poor prognosis after recurrence. Venous invasion correlated with early recurrence. Adjuvant chemotherapy may reduce the risk of early recurrence. These results indicate the importance of prudent surveillance and the aggressive application of adjuvant chemotherapy.

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Acknowledgements

We thank all of the staff who performed the clinical treatment and were responsible for the management of patients in the study. The authors declare that they have no conflicts of interest.

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Authors and Affiliations

  1. Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyo-ku, Kyoto, 6028566, Japan

    Hirotaka Furuke, Tomohiro Arita, Yoshiaki Kuriu, Hiroki Shimizu, Jun Kiuchi, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Hisashi Ikoma, Takeshi Kubota, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto & Eigo Otsuji

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  1. Hirotaka Furuke
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Correspondence to Tomohiro Arita.

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595_2021_2336_MOESM1_ESM.pdf

Supplementary file1 Supplementary Fig. 1. Survival curves of the OS after recurrence by the other cut-off points. OS: overall survival, TTR: time to recurrence. (PDF 98 kb)

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Furuke, H., Arita, T., Kuriu, Y. et al. The survival after recurrence of colorectal cancer: a retrospective study focused on time to recurrence after curative resection. Surg Today 52, 239–250 (2022). https://doi.org/10.1007/s00595-021-02336-z

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  • DOI: https://doi.org/10.1007/s00595-021-02336-z

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