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Predictive factors of gallstone formation after sleeve gastrectomy: a multivariate analysis of risk factors

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Abstract

Purpose

Obesity and bariatric surgery are both risk factors for cholelithiasis (CL). However, most previous studies have focused on Roux-en-Y gastric bypass, and limited published data are available for sleeve gastrectomy (SG).

Methods

Patients were evaluated in two groups depending on the presence of gallstones (Group I, present; Group II, absent). Demographic characteristics, comorbid diseases, pre-operative blood values, and early and late weight loss rates were compared between the groups.

Results

The study included 111 patients with a mean age of 38.9. The mean follow-up period was 20.6 (12–39) months. During follow-up, gallstone formation was observed in 36.9% (n = 41) of patients. Thirteen patients (31.8%) had symptomatic cholelithiasis that was resolved with laparoscopic cholecystectomy. The mean interval between sleeve gastrectomy and the detection of cholelithiasis was 210 days and the mean time of post-operative cholecystectomy was 540 days. A multivariate analysis showed that only dyslipidemia was independently and significantly associated with gallstone formation. There was no significant difference in the weight loss rate between the groups.

Conclusions

Although CL development was found to be associated with rapid weight loss in several published studies in post-SG patients, the present study showed no significant difference between the groups in terms of early or late weight loss. Pre-operative dyslipidemia may be associated with an increased risk of developing CL.

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Authors and Affiliations

  1. Department of General Surgery, University of Medical Sciences Keçioren Training and Research Hospital, Pınarbası Mah. Sanatoryum Cad. Ardahan Sok. No. 25, 06380, Keçioren, Ankara, Turkey

    Mustafa Alimoğulları & Hakan Buluş

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  1. Mustafa Alimoğulları
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  2. Hakan Buluş
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Correspondence to Mustafa Alimoğulları.

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Alimoğulları, M., Buluş, H. Predictive factors of gallstone formation after sleeve gastrectomy: a multivariate analysis of risk factors. Surg Today 50, 1002–1007 (2020). https://doi.org/10.1007/s00595-020-01971-2

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  • DOI: https://doi.org/10.1007/s00595-020-01971-2

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