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Video-assisted thoracoscopic surgery node dissection for lung cancer treatment

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Abstract

Purpose

Mediastinal node dissection (MND) is an integral component of the surgical treatment for non-small cell lung cancer (NSCLC). Although video-assisted thoracoscopic surgery (VATS) has been used increasingly for lung cancer treatment, the accuracy of by VATS MND still remains controversial. We reviewed the surgical results of VATS MND for NSCLC.

Methods

A systematic review of literature was performed, and articles that fully described the surgical procedure, devices, and results of VATS MND were selected to compare the efficacy of MND by VATS and thoracotomy.

Results

Various techniques and equipments have been shown to perform adequate MND, but there is an argument as to the method of estimation of the accuracy of MND. Most of the recent studies showed that the nodal upstaging and number of dissected nodes are significantly lower by VATS than after thoracotomy. Oppositely, some studies showed VATS noninferiority in these issues. Complications such as chylothorax, pleural effusion, bleeding, and nerve damage were similar in both groups.

Conclusions

Although ND by VATS remains controversial, VATS MND is becoming easier and more feasible owing to the development of more advanced endoscopic cameras and equipments. We should learn further to become more adept at performing adequate ND by VATS.

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References

  1. McKenna RJ Jr, Houck W, Fuller CB. Video-assisted thoracic surgery lobectomy: experience with 1,100 cases. Ann Thorac Surg. 2016;81:421–6.

    Article  Google Scholar 

  2. Licht PB, Jørgensen OD, Ladegaard L, Jakobsen E. A national study of nodal upstaging after thoracoscopic versus open lobectomy for clinical stage I lung cancer. Ann Thorac Surg. 2013;96:943–50.

    Article  PubMed  Google Scholar 

  3. Scott WJ, Allen MS, Darling G, Meyers B, Decker PA, Putnam JB, et al. Video-assisted thoracic surgery versus open lobectomy for lung cancer: a secondary analysis of data from the American College of Surgeons Oncology Group Z0030 randomized clinical trial. J Thorac Cardiovas Surg. 2010;139:976–83.

    Article  Google Scholar 

  4. Scott WJ, Matteotti RS, Egleston BL, Oseni S, Flaherty JF. A comparison of perioperative outcomes of video-assisted thoracic surgical (VATS) lobectomy with open thoracotomy and lobectomy: results of an analysis using propensity score based weighting. Ann Surg Innov Res. 2010;4:1.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Lardinois D, De Leyn P, Van Schil P, Porta RR, Waller D, Passlick B, et al. ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer. Eur J Cardiothorac Surg. 2006;30:787–92.

    Article  PubMed  Google Scholar 

  6. Howington JA, Blum MG, Chang AC, Balekian AA, Murthy SC. Treatment of stage I and II non-small cell lung cancer: diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143:e278S–e313S.

    Article  CAS  PubMed  Google Scholar 

  7. D’Amico TA. Videothoracoscopic mediastinal lymphadenectomy. Thorac Surg Clin. 2010;20:207–13.

    Article  PubMed  Google Scholar 

  8. De Giacomo T, Venuta F, Rendina EA. Role of lymphadenectomy in the treatment of clinical stage I non-small cell lung cancer. Thorac Surg Clin. 2007;17:217–21.

    Article  PubMed  Google Scholar 

  9. De Leyn P, Lardinois D, Van Schil P, Rami-Porta R, Passlick B, Zielinski M, et al. ESTS. European trends in preoperative and intraoperative nodal staging: ESTS guidelines. J Thorac Oncol. 2007;2:357–61.

    Article  PubMed  Google Scholar 

  10. Amer K, Khan A-Z, Singh N, Addis B, Jogai S, Harden S, et al. Video-assisted thoracic surgery systematic mediastinal nodal dissection and stage migration: impact on clinical pathway. Eur J Cardiothorac Surg. 2011;40:1474–81.

    PubMed  Google Scholar 

  11. Watanabe A, Nakazawa J, Miyajima M, Harada R, Nakashima S, Mawatari T, et al. Thoracoscopic mediastinal lymph node dissection for lung cancer. Semin Thorac Cardiovasc Surg. 2012;24:68–73.

    Article  PubMed  Google Scholar 

  12. Nagashima T. Thoracoscopic left mediastinal lymph node dissection. Ann Transl Med. 2016;4:10.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Baste JM, Haddad L, Melki J, Peillon C. Anterior subcarinal node dissection on the left side using video thoracoscopy: an easier technique. Ann Thorac Surg. 2015;99:e99–e100.

    Article  PubMed  Google Scholar 

  14. Witte B, Messerschmidt A, Hillebrand H, Gross S, Wolf M, Kriegel E, et al. Combined videothoracoscopic and videomediastinoscopic approach improves radicality of minimally invasive mediastinal lymphadenectomy for early stage lung carcinoma. Eur J Cardiothorac Surg. 2009;35:343–7.

    Article  PubMed  Google Scholar 

  15. Lin Z, Xu S, Wang Q. Uniportal video-assisted thoracoscopic surgery right upper lobectomy with systematic lymphadenectomy in a semiprone position. J Thorac Dis. 2014;6:1840–2.

    PubMed  PubMed Central  Google Scholar 

  16. Lin Z, Xi J, Xu S, Jiang W, Wang L, Wang Q. Uniportal video-assisted thoracic surgery lobectomy in semiprone position: primary experience of 105 cases. J Thorac Dis. 2015;7:2389–95.

    PubMed  PubMed Central  Google Scholar 

  17. Akiba T, Marushima H, Hirano K, Morikawa T. Thoracoscopic mediastinal lymph node dissection using an endoscopic spacer. Ann Thorac Cardiovasc Surg. 2012;18:281–3.

    Article  PubMed  Google Scholar 

  18. Hirai K, Ibi T, Bessho R, Koizumi K, Shimizu K. Use of the “Secrea (Hogy™)” sponge spacer in thoracoscopic surgery for lung cancer. J Surg Oncol. 2011;104:857–8.

    Article  CAS  PubMed  Google Scholar 

  19. Sato Y, Tezuka Y, Kanai Y, Otani S, Yamamoto S, Tetsuka K, et al. Novel retractor for lymph node dissection by video-assisted thoracic surgery. Ann Thorac Surg. 2008;8:1036–7.

    Article  Google Scholar 

  20. Sagawa M, Sato M, Sakurada A, Matsumura Y, Endo C, Handa M, Kondo T. A prospective trial of systematic nodal dissection for lung cancer by video-assisted thoracic surgery: can it be perfect? Ann Thorac Surg. 2002;73:900–4.

    Article  PubMed  Google Scholar 

  21. Watanabe A, Koyanagi T, Ohsawa H, Mawatari T, Nakashima S, Takahashi N, et al. Systematic node dissection by VATS is not inferior to that through an open thoracotomy: a comparative clinicopathologic retrospective study. Surgery. 2005;1383:510–7.

    Article  Google Scholar 

  22. D’Amico TA, Niland J, Mamet R, Zornosa C, Dexter EU, Onaitis MW. Efficacy of mediastinal lymph node dissection during lobectomy for lung cancer by thoracoscopy and thoracotomy. Ann Thorac Surg. 2011;92:226–31.

    Article  PubMed  Google Scholar 

  23. Palade E, Passlick B, Osei-Agyemang T, Günter J, Wiesemann S. Video-assisted vs. open mediastinal lymphadenectomy for stage I non-small-cell lung cancer: results of a prospective randomized trial. Eur J Cardiothorac Surg. 2013;44:244–9.

    Article  PubMed  Google Scholar 

  24. Amer K, Khan AZ, Singh N, Addis B, Jogai S, Harden S, et al. Video-assisted thoracic surgery systematic mediastinal nodal dissection and stage migration: impact on clinical pathway. Eur J Cardiothorac Surg. 2011;406:1474–81.

    Google Scholar 

  25. Martin JT, Durbin EB, Chen L, Gal T, Mahan A, Ferraris V, et al. Nodal upstaging during lung cancer resection is associated with surgical approach. Ann Thorac Surg. 2016;101:238–445.

    Article  PubMed  Google Scholar 

  26. Kocher F, Ng C, Augustin F. On the article “Nodal upstaging is more common with thoracotomy than with VATS during lobectomy for early-stage lung cancer: an analysis from the National Cancer Data Base” by Medbery et al. J Thorac Oncol. 2016;11:e103–4.

    Article  PubMed  Google Scholar 

  27. Scott WJ, Allen MS, Darling G, Meyers B, Decker PA, Putnam JB, et al. Video-assisted thoracic surgery versus open lobectomy for lung cancer: a secondary analysis of data from the American College of Surgeons Oncology Group Z0030 randomized clinical trial. J Thorac Cardiovasc Surg. 2010;139:976–83.

    Article  PubMed  Google Scholar 

  28. Medbery RL, Gillespie TW, Liu Y, Nickleach DC, Lipscomb J, Sancheti MS, et al. Nodal upstaging is more common with thoracotomy than with VATS during lobectomy for early-stage lung cancer: an analysis from the National Cancer Data Base. J Thorac Oncol. 2016;11:222–33.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Wang W, Yin W, Shao W, Jiang G, Wang Q, Liu L, et al. Comparative study of systematic thoracoscopic lymphadenectomy and conventional thoracotomy in resectable non-small cell lung cancer. J Thorac Dis. 2014;6:45–51.

    PubMed  PubMed Central  Google Scholar 

  30. Whitson BA, Andrade RS, Boettcher A, Bardales R, Kratzke RA, Dahlberg PS, et al. Video-assisted thoracoscopic surgery is more favorable than thoracotomy for resection of clinical stage I non-small cell lung cancer. Ann Thorac Surg. 2007;83:1965–70.

    Article  PubMed  Google Scholar 

  31. Denlinger CE, Fernandez F, Meyers BF, Pratt W, Zoole JB, Patterson GA, et al. Lymph node evaluation in video-assisted thoracoscopic lobectomy versus lobectomy by thoracotomy. Ann Thorac Surg. 2010;89:1730–6.

    Article  PubMed  Google Scholar 

  32. Boffa DJ, Kosinski AS, Paul S, Mitchell JD, Onaitis M. Lymph node evaluation by open or video-assisted approaches in 11,500 anatomic lung cancer resections. Ann Thorac Surg. 2012;94:347–53.

    Article  PubMed  Google Scholar 

  33. Merritt RE, Hoang CD, Shrager JB. Lymph node evaluation achieved by open lobectomy compared with thoracoscopic lobectomy for N0 lung cancer. Ann Thorac Surg. 2013;96:117–7.

    Article  Google Scholar 

  34. Kim K, Kim HK, Park JS, Chang SW, Choi YS, Kim J, et al. Video-assisted thoracic surgery lobectomy: single institutional experience with 704 cases. Ann Thorac Surg. 2010;89:S2118–22.

    Article  PubMed  Google Scholar 

  35. Cerfolio RJ, Bryant AS, Minnich DJ. Complete thoracic mediastinal lymphadenectomy leads to a higher rate of pathologically proven N2 disease in patients with non-small cell lung cancer. Ann Thorac Surg. 2012;94:902–6.

    Article  PubMed  Google Scholar 

  36. Ratto G, Ratto GB, Costa R, Maineri P, Alloisio A, Bruzzi P, et al. Is there a subset of patients with preoperatively diagnosed N2 non-small cell lung cancer who might benefit from surgical resection? J Thorac Cardiovasc Surg. 2009;138:849–58.

    Article  PubMed  Google Scholar 

  37. Watanabe A, Mishina T, Ohori S, Koyanagi T, Nakashima S, Mawatari T, et al. Is video-assisted thoracoscopic surgery a feasible approach for clinical N0 and postoperatively pathological N2 non-small cell lung cancer? Eur J Cardiothorac Surg. 2008;33:812–8.

    Article  PubMed  Google Scholar 

  38. Zhong C, Yao F, Zhao H. Clinical outcomes of thoracoscopic lobectomy for patients with clinical N0 and pathologic N2 non-small cell lung cancer. Ann Thorac Surg. 2013;95:987–92.

    Article  PubMed  Google Scholar 

  39. Katayama H, Kurokawa Y, Nakamura K, Ito H, Kanemitsu Y, Masuda N, et al. Extended Clavien–Dindo classification of surgical complications: Japan Clinical Oncology Group postoperative complications criteria. Surg Today. 2016;46:668–85.

    Article  PubMed  Google Scholar 

  40. Muranishi Y, Sonobe M, Menju T, Aoyama A, Chen-Yoshikawa TF, et al. Atrial fibrillation after lung cancer surgery: incidence, severity, and risk factors. Surg Today. 2017;47:252–8.

    Article  PubMed  Google Scholar 

  41. Kanzaki R, Inoue M, Minami M, Shintani Y, Funaki S, Kawamura T, et al. Outcomes of lung cancer surgery in patients with coronary artery disease: a decade of experience at a single institution. Surg Today. 2017;47:27–34.

    Article  PubMed  Google Scholar 

  42. Liu CY, Hsu PK, Huang CS, Sun YH, Wu YC, Hsu WH. Chylothorax complicating video-assisted thoracoscopic surgery for non-small cell lung cancer. World J Surg. 2014;38:2875–81.

    Article  PubMed  Google Scholar 

  43. Paul S, Sedrakyan A, Chiu YL, Nasar A, Port JL, Lee PC, et al. Outcomes after lobectomy using thoracoscopy vs. thoracotomy: a comparative effectiveness analysis utilizing the Nationwide Inpatient Sample database. Eur J Cardiothorac Surg. 2013;43:813–7.

    Article  PubMed  Google Scholar 

  44. Gharagozloo F, Tempesta B, Margolis M, Alexander EP. Video-assisted thoracic surgery lobectomy for stage I lung cancer. Ann Thorac Surg. 2003;76:1009–15.

    Article  PubMed  Google Scholar 

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Correspondence to Atsushi Watanabe.

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Watanabe, A., Miyajima, M., Mishina, T. et al. Video-assisted thoracoscopic surgery node dissection for lung cancer treatment. Surg Today 47, 1419–1428 (2017). https://doi.org/10.1007/s00595-017-1494-x

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