Skip to main content
SpringerLink
Log in

Sintilimab-induced autoimmune diabetes mellitus manifesting as diabetic ketoacidosis in a patient with advanced esophageal squamous cell carcinoma

  • Case Report
  • Published:
Acta Diabetologica Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Kojima T, Hara H, Tsuji A et al (2022) First-line pembrolizumab + chemotherapy in Japanese patients with advanced/metastatic esophageal cancer from KEYNOTE-590. Esophagus 19(4):683–692. https://doi.org/10.1007/s10388-022-00920-x

    Article  PubMed  PubMed Central  Google Scholar 

  2. Lv H, Tian Y, Li J et al (2022) Neoadjuvant sintilimab plus chemotherapy in resectable locally advanced esophageal squamous cell carcinoma. Front Oncol 12:864533. https://doi.org/10.3389/fonc.2022.864533

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Perdigoto AL, Quandt Z, Anderson M et al (2019) Checkpoint inhibitor-induced insulin-dependent diabetes: an emerging syndrome. Lancet Diabetes Endocrinol 7(6):421–423. https://doi.org/10.1016/s2213-8587(19)30072-5

    Article  PubMed  Google Scholar 

  4. Akturk HK, Kahramangil D, Sarwal A et al (2019) Immune checkpoint inhibitor-induced type 1 diabetes: a systematic review and meta-analysis. Diabet Med 36(9):1075–1081. https://doi.org/10.1111/dme.14050

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Wang K, Li F, Cui Y et al (2019) The association between depression and type 1 diabetes mellitus: Inflammatory cytokines as ferrymen in between? Mediat Inflamm 2019:2987901. https://doi.org/10.1155/2019/2987901

    Article  CAS  Google Scholar 

Download references

Funding

Funding is provided by the fund for endocrine and metabolic diseases key laboratory of Shanxi Province (Grant Number 202104010910009).

Author information

Authors and Affiliations

  1. Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China

    Nannan Lai, Xuemei Fan & Shiwei Liu

Authors
  1. Nannan Lai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Xuemei Fan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shiwei Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nannan Lai.

Ethics declarations

Conflict of interest

All authors disclosed no relevant. The author(s) declared no potential conflicts of interest with respect to the research, author- ship, and/or publication of this article.

Ethical approval

This study was conducted according to the Shanxi Bethune Hospital Center for Ethics’ advice. For the public release of this case as well as any information or photographs that could be used to identify the person, informed and written permission was sought from them.

Additional information

Managed by Antonio Secchi.

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lai, N., Fan, X. & Liu, S. Sintilimab-induced autoimmune diabetes mellitus manifesting as diabetic ketoacidosis in a patient with advanced esophageal squamous cell carcinoma. Acta Diabetol 61, 675–678 (2024). https://doi.org/10.1007/s00592-023-02232-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00592-023-02232-7

Search

Navigation