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C-reactive protein-to-albumin ratio and 8‐year incidence of type 2 diabetes: the Korean genome and epidemiology study

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Abstract

Aims

The C-reactive protein-to-albumin ratio (CAR) has been reported as a novel prognostic marker in serious illness and various inflammatory diseases. The aim of this study is to investigate the association of CAR with incidence risk of type 2 diabetes in adults without chronic disease.

Methods

A total of 5904 participants aged 40 to 69 years were selected from the Korean Genome and Epidemiology Study who were observed over 12 years. Multivariable logistic regression was analyzed to examine the relationship between CAR tertiles and incident diabetes. The predictive power of new-onset diabetes by CAR and homeostasis model assessment-insulin resistance (HOMA-IR) were also measured using the random forest model.

Results

During a mean follow-up period of 7.6 years, 701 subjects (11.9%) developed diabetes. Compared with the lowest CAR group, the highest CAR group was associated with incidence of diabetes (OR 1.60; 95% CI 1.24–1.89) after adjustment for other potential confounding factors. In the random forest model, CAR did not show a significant difference in prediction of new-onset diabetes compared with HOMA-IR (p = 0.561).

Conclusions

CAR, which is a ratio of commonly used biomarkers and reflects both oxidative stress and antioxidants, is suggested as a predictor of incident diabetes.

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Acknowledgements

We specially thank to Dr. T.S.Lee who gave scientific advice.

Funding

No funding was provided.

Author information

Author notes

  1. A.-Ra Cho and Sung‐Bum Lee are authors who equally contributed to this work.

Authors and Affiliations

  1. Department of Family Medicine, Yong-in Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin Si, Gyeonggi-do, 16995, Republic of Korea

    A.-Ra Cho & Dong‐Hyuk Jung

  2. Department of Medicine, Graduate School, Yonsei University Wonju College of Medicine, Wonju, 26426, Republic of Korea

    Sung‐Bum Lee

  3. TheragenEtex BioInstitue Co., Ltd., Suwon, 16229, Republic of Korea

    Kyung-Won Hong

Authors
  1. A.-Ra Cho
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  2. Sung‐Bum Lee
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  4. Dong‐Hyuk Jung
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Correspondence to Dong‐Hyuk Jung.

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Ethics approvals for the study protocol and analysis of the data were obtained from the Institutional Review Board of Yonsei University College of Medicine.

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Informed consent was obtained from all individual participants included in the study.

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Cho, AR., Lee, S., Hong, KW. et al. C-reactive protein-to-albumin ratio and 8‐year incidence of type 2 diabetes: the Korean genome and epidemiology study. Acta Diabetol 58, 1525–1532 (2021). https://doi.org/10.1007/s00592-021-01755-1

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  • DOI: https://doi.org/10.1007/s00592-021-01755-1

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