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Outcomes of free vascularised fibular graft reconstruction in upper limb trauma—a systematic review

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Abstract

Purpose

To evaluate existing literature describing the use of free fibular flaps in upper extremity trauma and summarise flap outcomes. Secondary objectives are to evaluate patient demographics and flap characteristics.

Methods

EMBASE, PubMed, MEDLINE and the Cochrane Database were searched for eligible studies published from 1975 to January 2019. Primary outcome measures collected were rate of union, graft survival rate, and complication rates. Patient demographics and flap characteristics were also collected. Statistical analysis was performed using SPSS software (SPSS version 25; IBM, Chicago, USA). Pooled data were presented as mean and standard deviation or median and range. Categorical variables were assessed by chi-squared test. Quality of studies were assessed using the National Institutes of Health (NIH) Quality Assessment Tool for case series studies.

Results

Initial search yielded 1070 articles. A total of 25 studies (151 cases) met the inclusion criteria. Flap survival was 97% (147/151) at time of follow-up, with first union rate of 95% (142/151) and second union rate of 97% (147/151) following bone graft or further procedure. Overall complication rate was 33% (47/140). There was a statistically significant association between recipient flap site and rates of flap fracture (p = 0.049). There was no statistically significant association between flap type, evidence of infection at donor or defect site, or method of flap fixation on outcomes.

Conclusions

Vascularised fibular flaps are a safe and efficacious reconstructive option for upper limb trauma. Further research is required to enable better understanding of the impact of patient and clinical factors on flap outcome measures.

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References

  1. Cano-Luís P, Andrés-Cano P, Ricón-Recarey FJ, Giráldez-Sánchez MA (2018) Treatment of posttraumatic bone defects of the forearm with vascularized fibular grafts. Follow up after fourteen years. Injury 49(Suppl 2):S27–S35. https://doi.org/10.1016/j.injury.2018.07.021

    Article  PubMed  Google Scholar 

  2. Landau MJ, Badash I, Yin C, Alluri RK, Patel KM (2018) Free vascularized fibula grafting in the operative treatment of malignant bone tumors of the upper extremity: a systematic review of outcomes and complications. J Surg Oncol 117(7):1432–1439. https://doi.org/10.1002/jso.25032

    Article  PubMed  Google Scholar 

  3. Beris AE, Lykissas MG, Korompilias AV, Vekris MD, Mitsionis GI, Malizos KN, Soucacos PN (2011) Vascularized fibula transfer for lower limb reconstruction. Microsurgery 31(3):205–211. https://doi.org/10.1002/micr.20841

    Article  PubMed  Google Scholar 

  4. Bishop AT, Shin AY (2011) Vascularized Bone Grafting. In: Wolfe SW, Hotchkiss RN, Pederson WC, Kozin SH (eds) Green’s Operative Hand Surgery, 6th edn. Elsevier, Philadelphia, pp 1603–1644

    Google Scholar 

  5. Wei FC, El-Gammal TA, Lin CH, Ueng WN (1997) Free fibula osteoseptocutaneous graft for reconstruction of segmental femoral shaft defects. J Trauma 43(5):784–792. https://doi.org/10.1097/00005373-199711000-00009

    Article  CAS  PubMed  Google Scholar 

  6. Bieber EJ, Wood MB (1986) Bone reconstruction. Clin Plast Surg 13(4):645–655

    Article  CAS  PubMed  Google Scholar 

  7. Gan AW, Puhaindran ME, Pho RW (2013) The reconstruction of large bone defects in the upper limb. Injury 44(3):313–317. https://doi.org/10.1016/j.injury.2013.01.014

    Article  PubMed  Google Scholar 

  8. Weiland AJ, Kleinert HE, Kutz JE, Daniel RK (1979) Free vascularized bone grafts in surgery of the upper extremity. J Hand Surg 4(2):129–144. https://doi.org/10.1016/s0363-5023(79)80129-x

    Article  CAS  Google Scholar 

  9. Bae DS, Waters PM (2006) Free vascularized fibula grafting: principles, techniques, and applications in pediatric orthopaedics. Orthop J Harv Med Sch 8:86–89

    Google Scholar 

  10. de Boer, H. H., & Wood, M. B. (1989). Bone changes in the vascularised fibular graft. J Bone Jt Surg. British volume, 71(3), 374–378. https://doi.org/10.1302/0301-620X.71B3.2722923

  11. Taylor GI, Miller GD, Ham FJ (1975) The free vascularized bone graft. A clinical extension of microvascular techniques. Plast Reconstr Surg 55(5):533–544. https://doi.org/10.1097/00006534-197505000-00002

    Article  CAS  PubMed  Google Scholar 

  12. Kremer T, Bickert B, Germann G, Heitmann C, Sauerbier M (2006) Outcome assessment after reconstruction of complex defects of the forearm and hand with osteocutaneous free flaps. Plast Reconstr Surg 118(2):443–456. https://doi.org/10.1097/01.prs.0000227742.66799.74

    Article  CAS  PubMed  Google Scholar 

  13. Bumbasirevic M, Stevanovic M, Bumbasirevic V, Lesic A, Atkinson HD (2014) Free vascularised fibular grafts in orthopaedics. Int Orthop 38(6):1277–1282. https://doi.org/10.1007/s00264-014-2281-6

    Article  PubMed  PubMed Central  Google Scholar 

  14. Heitmann, C., Erdmann, D., & Levin, L. S. (2002). Treatment of segmental defects of the humerus with an osteoseptocutaneous fibular transplant. J Bone Jt Surg. American volume, 84(12), 2216–2223. https://doi.org/10.2106/00004623-200212000-00014

  15. Joneschild E, Urbaniak JR (2005) Biology of the vascularized fibular graft. In: Lieberman JR, Friedlaender GE (eds) Bone generation and repair: biology and clinical applications. Humana, New York, pp 93–112

    Chapter  Google Scholar 

  16. Pototschnig H, Schaff J, Kovacs L, Biemer E, Papadopulos NA (2013) The free osteofasciocutaneous fibula flap: clinical applications and surgical considerations. Injury 44(3):366–369. https://doi.org/10.1016/j.injury.2013.01.007

    Article  PubMed  Google Scholar 

  17. Korompilias AV, Paschos NK, Lykissas MG, Kostas-Agnantis I, Vekris MD, Beris AE (2011) Recent updates of surgical techniques and applications of free vascularized fibular graft in extremity and trunk reconstruction. Microsurgery 31(3):171–175. https://doi.org/10.1002/micr.20848

    Article  PubMed  Google Scholar 

  18. Jupiter JB, Fernandez DL, Levin LS, Wysocki RW (2010) Reconstruction of posttraumatic disorders of the forearm. Instr Course Lect 59:283–293

    PubMed  Google Scholar 

  19. Houdek, M. T., Bayne, C. O., Bishop, A. T., & Shin, A. Y. (2017). The outcome and complications of vascularised fibular grafts. Bone Jt J, 99-B(1), 134–138. https://doi.org/10.1302/0301-620X.99B1.BJJ-2016-0160.R1

  20. Study Quality Assessment Tools | NHLBI, NIH. (2019, May 21). National Institutes of Health. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools. Accessed 22nd September 2021.

  21. Adani R, Delcroix L, Innocenti M, Marcoccio I, Tarallo L, Celli A, Ceruso M (2004) Reconstruction of large posttraumatic skeletal defects of the forearm by vascularized free fibular graft. Microsurgery 24(6):423–429. https://doi.org/10.1002/micr.20067

    Article  PubMed  Google Scholar 

  22. Adani R, Delcroix L, Innocenti M, Tarallo L, Baccarani A (2008) Free fibula flap for humerus segmental reconstruction: report on 13 cases. La Chirurgia degli organi di movimento 91(1):21–26. https://doi.org/10.1007/s12306-007-0004-5

    Article  PubMed  Google Scholar 

  23. Beredjiklian PK, Hotchkiss RN, Athanasian EA, Ramsey ML, Katz MA (2005) Recalcitrant nonunion of the distal humerus: treatment with free vascularized bone grafting. Clin Orthop Relat Res 435:134–139

    Article  Google Scholar 

  24. Cavadas PC, Landin L, Thione A, Ibañez J, Nthumba P, Roger I (2010) Reconstruction of massive bone losses of the elbow with vascularized bone transfers. Plast Reconstr Surg 126(3):964–972. https://doi.org/10.1097/PRS.0b013e3181e6b0b9

    Article  CAS  PubMed  Google Scholar 

  25. Chai Y-M, Wang C-Y, Zeng B-F, Chen Z-G, Cai P-H, Kang Q-L, Ruan H-J (2010) Peroneal artery perforator chimeric flap for reconstruction of composite defects in extremities. Microsurgery 30:199–206. https://doi.org/10.1002/micr.20729

    Article  PubMed  Google Scholar 

  26. Giessler GA, Schmidt AB, Germann G, Pelzer M (2011) The role of fabricated chimeric free flaps in reconstruction of devastating hand and forearm injuries. J Reconstr Microsurg 27(9):567–573. https://doi.org/10.1055/s-0031-1287672

    Article  PubMed  Google Scholar 

  27. Hameed S, Ehtesham-ul-haq RH, Ahmed RS, Majid A, Waqas M, Aslam A, Yusuf O, Butt AM, Ali G (2013) Use of vascularised free fibula in limb reconstruction (for non-malignant defects). JPMA 63(12):1549–1554

    Google Scholar 

  28. Hirayama T, Suematsu N, Inoue K, Baitoh C, Takemitsu Y (1985) Free vascularised bone grafts in reconstruction of the upper extremity. J Hand Surg 10(2):169–175. https://doi.org/10.1016/0266-7681_85_90008-7

    Article  CAS  Google Scholar 

  29. Jupiter J. B. (1990). Complex non-union of the humeral diaphysis. Treatment with a medial approach, an anterior plate, and a vascularized fibular graft. J Bone Jt Surg. American volume, 72(5), 701–707.

  30. Jupiter, J. B., Gerhard, H. J., Guerrero, J., Nunley, J. A., & Levin, L. S. (1997). Treatment of segmental defects of the radius with use of the vascularized osteoseptocutaneous fibular autogenous graft. J Bone Jt Surg. American volume, 79(4), 542–550. https://doi.org/10.2106/00004623-199704000-00009

  31. Kerfant N, Valenti P, Kilinc AS, Falcone MO (2012) Free vascularised fibular graft in multi-operated patients for an aseptic non-union of the humerus with segmental defect: surgical technique and results. Orthop Traumatol, Surg Res: OTSR 98(5):603–607. https://doi.org/10.1016/j.otsr.2012.03.013

    Article  CAS  PubMed  Google Scholar 

  32. Lee HB, Tark KC, Kang SY, Kim SW, Chung YK (2000) Reconstruction of composite metacarpal defects using a fibula free flap. Plast Reconstr Surg 105(4):1448–1452. https://doi.org/10.1097/00006534-200004040-00029

    Article  CAS  PubMed  Google Scholar 

  33. Lin CH, Wei FC, Rodriguez ED, Lin YT, Chen CT (2005) Functional reconstruction of traumatic composite metacarpal defects with fibular osteoseptocutaneous free flap. Plast Reconstr Surg 116(2):605–612. https://doi.org/10.1097/01.prs.0000173554.46455.5a

    Article  CAS  PubMed  Google Scholar 

  34. Malizos KN, Beris AE, Xenakis TA, Korobilias AB, Soucacos PN (1992) Free vascularized fibular graft: a versatile graft for reconstruction of large skeletal defects and revascularization of necrotic bone. Microsurgery 13(4):182–187. https://doi.org/10.1002/micr.1920130407

    Article  CAS  PubMed  Google Scholar 

  35. Muramatsu K, Doi K, Ihara K, Shigetomi M, Kawai S (2003) Recalcitrant posttraumatic nonunion of the humerus: 23 patients reconstructed with vascularized bone graft. Acta Orthop Scand 74(1):95–97. https://doi.org/10.1080/00016470310013734

    Article  PubMed  Google Scholar 

  36. Minami A, Kaneda K, Itoga H, Usui M (1989) Free vascularized fibular grafts. J Reconstr Microsurg 5(1):37–43. https://doi.org/10.1055/s-2007-1006849

    Article  CAS  PubMed  Google Scholar 

  37. Olekas J, Guobys A (1991) Vascularised bone transfer for defects and pseudarthroses of forearm bones. J Hand Surg (Edinburgh, Scotland) 16(4):406–408. https://doi.org/10.1016/0266-7681(91)90013-e

    Article  CAS  Google Scholar 

  38. Repo JP, Sommarhem A, Roine RP, Sintonen H, Halonen T, Tukiainen E (2016) Free vascularized fibular graft is reliable in upper extremity long-bone reconstruction with good long-term outcomes. J Reconstr Microsurg 32(7):513–519. https://doi.org/10.1055/s-0036-1581075

    Article  PubMed  Google Scholar 

  39. Safoury Y (2005) Free vascularized fibula for the treatment of traumatic bone defects and nonunion of the forearm bones. J Hand Surg (Edinburgh, Scotland) 30(1):67–72. https://doi.org/10.1016/j.jhsb.2004.09.007

    Article  CAS  Google Scholar 

  40. Simsek T, Engin MS, Demir A, Tayfur V, Eroglu L (2012) Reconstruction of hand injuries with multiple metacarpal defects using free fibular osteoseptocutaneous flap. Microsurgery 32(7):520–526. https://doi.org/10.1002/micr.21977

    Article  PubMed  Google Scholar 

  41. Yücetürk A, Tuncay C, Işiklar U, Tandoğan R (1998) Vascularised bone graft applications in upper extremity problems. Microsurgery 18(3):160–162. https://doi.org/10.1002/(sici)1098-2752(1998)18:3%3c160::aid-micr5%3e3.0.co;2-p

    Article  PubMed  Google Scholar 

  42. Hollenbeck ST, Komatsu I, Woo S, Schoeman M, Yang J, Erdmann D, Levin LS (2011) The current role of the vascularized-fibular osteocutaneous graft in the treatment of segmental defects of the upper extremity. Microsurgery 31(3):183–189

    Article  PubMed  Google Scholar 

  43. Chen ZW, Yan W (1983) The study and clinical application of the osteocutaneous flap of fibula. Microsurgery 4(1):11–16. https://doi.org/10.1002/micr.1920040107

    Article  CAS  PubMed  Google Scholar 

  44. Yoshimura, M., Shimamura, K., Iwai, Y., Yamauchi, S., & Ueno, T. (1983). Free vascularized fibular transplant. A new method for monitoring circulation of the grafted fibula. J Bone Jt Surg. American volume, 65(9), 1295–1301.

  45. Wei FC, Chen HC, Chuang CC, Noordhoff MS (1986) Fibular osteoseptocutaneous flap: anatomic study and clinical application. Plast Reconstr Surg 78(2):191–200. https://doi.org/10.1097/00006534-198608000-00008

    Article  CAS  PubMed  Google Scholar 

  46. Shi LL, Jawa A, Jupiter JB (2008) Long term bone changes in vascularised fibula grafts. Orthop J Harv Med Sch 10:103–105

    Google Scholar 

  47. Liu S, Tao S, Tan J, Hu X, Liu H, Li Z (2018) Long-term follow-up of fibular graft for the reconstruction of bone defects. Medicine 97(40):e12605. https://doi.org/10.1097/MD.0000000000012605

    Article  PubMed  PubMed Central  Google Scholar 

  48. Hsu, R. W., Wood, M. B., Sim, F. H., & Chao, E. Y. (1997). Free vascularised fibular grafting for reconstruction after tumour resection. J Bone Jt Surg. British volume, 79(1), 36–42. https://doi.org/10.1302/0301-620x.79b1.6818

  49. Shea KG, Coleman DA, Scott SM, Coleman SS, Christianson M (1997) Microvascularized free fibular grafts for reconstruction of skeletal defects after tumor resection. J Pediatr Orthop 17(4):424–432

    Article  CAS  PubMed  Google Scholar 

  50. Lambert K. L. (1971). The weight-bearing function of the fibula. A strain gauge study. J Bone Jt Surg. American volume, 53(3), 507–513.

  51. Pacelli, L. L., Gillard, J., McLoughlin, S. W., & Buehler, M. J. (2003). A biomechanical analysis of donor-site ankle instability following free fibular graft harvest. J Bone Jt Surg. American volume, 85(4), 597–603. https://doi.org/10.2106/00004623-200304000-00002

  52. Aberg M, Rydholm A, Holmberg J, Wieslander JB (1988) Reconstruction with a free vascularized fibular graft for malignant bone tumor. Acta Orthop Scand 59(4):430–437. https://doi.org/10.3109/17453678809149397

    Article  CAS  PubMed  Google Scholar 

  53. Bishop, A. T., Wood, M. B., & Sheetz, K. K. (1995). Arthrodesis of the ankle with a free vascularized autogenous bone graft. Reconstruction of segmental loss of bone secondary to osteomyelitis, tumor, or trauma. J Bone Jt Surg. American volume, 77(12), 1867–1875. https://doi.org/10.2106/00004623-199512000-00011

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Table 5 NIH quality assessment tool

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Liaw, F., Teoh, S.H., Stevens-Harris, I. et al. Outcomes of free vascularised fibular graft reconstruction in upper limb trauma—a systematic review. Eur J Orthop Surg Traumatol 33, 207–223 (2023). https://doi.org/10.1007/s00590-021-03185-9

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