Abstract
Report on epizootic lymphangitis, a chronic contagious zoonosis of Equidae caused by Histoplasma capsulatum var. farciminosum characterized clinically by pyogranulomatous multifocal dermatitis with lymphadenitis, is rare in donkeys. This case reports a 6-year-old, 200-kg local male donkey at the University of Ibadan zoological garden with wounds on its dorsum which developed into ulcerative lesions on the left cranial thoracic region. The lesions were also along the lymphatic drainage of the left infrascapular area down to the girth with extensive nodular lesions on the skin, characteristic focal ulcers and fenestrations along the left flank. The ulcers were recurrent with blockage of the left lymphatic drainage causing ventral edema of the sternum extending to the prepuce and the left forelimb. The wound was managed for about 1 year but remained persistent with episodes of apparent healing, scarification and recurrence. Tentative diagnosis of epizootic lymphangitis was made. Blood sample, pus swab and aspirated exudate were collected for confirmatory diagnosis using light microscopy and polymerase chain reaction (PCR) to detect and amplify a fragment of the internal transcribed spacer-2 (ITS-2) gene. These techniques detected Histoplasma capsulatum var. farciminosum, which informed the use of appropriate therapeutic agents, providone iodine wash, and griseofulvin cream and tablets for 3 weeks to treat the disease condition.
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References
Abdisa T (2017) Review on Equine epizootic lymphangitis and its impact in Ethiopia. J Vet Med Res 4(5):1087–1093
Al-Ani FK (1989) Epizootic lymphangitis in horses: a goal for diagnosis, treatment and control? In Proc. 6th Technical Conference of animal diseases in the Arab world, 18-21 March, Baghdad. General Federation of Arab Veterinarians, Iraqi Veterinary Medical Syndicate, Baghdad, 11-22.
Ameni G, Terefe W (2004) A cross-sectional study of epizootic lymphangitis in cart-mules in western Ethiopia. Preventive Vet Med 66:93–99
Fouad KM, Saleh S, Sokkar S, Shouman MT (1973) Studies on lachrymal histoplasmosis in donkeys in Egypt. Zentralbl Veterinarmed B 20:584–593
Guerin C, Abebe S, Touati F (1992) Epizootic lymphangitis in horses in Ethiopia. J Mycol Med 2:1–5
Jubb KV, Kennedy PC, Palmer N (1985) Epizootic lymphangitis in pathology of domestic animals, vol 3, 4th edn. Academic Press, New York, pp 82–84
Meselu D, Abebe R, Mekibib B (2018) Lymphangitis and bodily distribution of lesions in Cart-Mules in Bahir Dar town, Northwest Ethiopia. J Vet Sci Techol 9(1):509
Pal M (2019) Occurrence of cutaneous epizootic lymphangitis in working donkeys in Debre Zeit, Ethiopia. EC Microbiology 15(5):382–384
Quinn PJ, Carter ME, Markey B, Carter GR (1994) Veterinary clinical microbiology, 1st edn. Wolfe Publishing Company, London, p 407
Radostitis OM, Gay CC, Constable PD, Hinchliff KW (2007) Veterinary medicine. A text book of the diseases of cattle, sheep, goats and horses.10th ed, WB Saunders Co.
Selim SA, Soliman R, Osman K, Padhye AA, Ajello L (1985) Studies on histoplasmosis farciminosi (epizootic lymphangitis) in Egypt. Eur J Epidemiol 1(2):84–89
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The authors sincerely appreciate the efforts of Mpama IC and Nwagbara A in the histological processing of the tissues.
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The Institutional Review Board on Animal Care Use and Research Ethics of the University of Ibadan, Nigeria, approved the study.
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Adedokun, R.A.M., Fagbohun, O.A., Akinlabi, E.Y. et al. Clinicopathological features, molecular diagnosis and treatment of epizootic lymphangitis in a donkey at a university zoological garden: a case report. Comp Clin Pathol 29, 899–903 (2020). https://doi.org/10.1007/s00580-020-03112-0
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DOI: https://doi.org/10.1007/s00580-020-03112-0