Abstract
Surgeons conducting bone grafting procedures have been in search of a bone graft substitute to avoid autogenous bone harvesting because of its associated complications. In the present study, the authors used fish bone and fish DBM in healing of a radial bone defect in a rat model. The 16 female Sprague–Dawley rats used in the present study were divided into the following four groups: autograft (positive control), untreated defect (negative control), and fish DBM, and fish bone graft as the experimental groups. Radiographs were taken in the 1st, 35th, and 56th post-operative days. Histopathological and biomechanical evaluations were performed in 56th post-operative day. The radiological, histopathological, and biomechanical evaluations revealed a superior rate of bone formation in the fish bone graft and autograft groups compared to those of the control. This study showed that the fish bone graft is effective in healing of the radial bone defect in rat.
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The authors would like to thank the Shiraz University for their financial support and cooperation.
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Ahmad Oryan has received research grants from Shiraz University. Amin Bigham-Sadegh is a Shahrekord University member who performed all surgical procedures. Somaye Monazzah is a Ph. D student of Veterinary Pathology and co-operates during the whole study. Ahmad Oryan declares that he has no conflict of interest. Amin Bigham-Sadegh declares that he has no conflict of interest. Somaye Monazzah declares that she has no conflict of interest.
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This study was funded by grant number 94GRD1M1880.
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All guidelines for the care and use of animals were followed in accordance with the permission and prescribed guidelines of the Institutional Animal Ethics Committee.
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Oryan, A., Bigham-Sadegh, A. & Monazzah, S. Fish bone versus fish demineralized bone matrix (vertebra) effects on healing of experimental radial defect in rat model. Comp Clin Pathol 25, 981–985 (2016). https://doi.org/10.1007/s00580-016-2290-5
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DOI: https://doi.org/10.1007/s00580-016-2290-5