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Elevated high-mobility group box1 level is associated with alterations of interferon gamma in Egyptians with lupus nephritis

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Abstract

High-mobility group box protein-1 (HMGB1) is identified as a pro-inflammatory mediator of tissue injury. Interferon-gamma (IFN-γ) dose dependently induced the release of HMGB1. The understanding of systemic lupus erythematosus (SLE) cytokine networks is very important for SLE treatment strategy and drug development. The purpose of this study is to determine the association of HMGB1 and IFN-γ levels to lupus nephritis and their relation to disease activity, autoantibodies, and certain laboratory parameters. The study population consisted of 50 lupus nephritis patients compared to 30 age- and sex-matched healthy controls (HC). HMGB1 and IFN-γ levels were measured by ELISA method. The plasma levels of HMGB1 and IFN-γ were significantly increased in lupus nephritis patients compared to HC (P < 0.05 and P < 0.01, respectively). Additionally, plasma HMGB1 was positively correlated with IFN-γ (P < 0.001), creatinine (P < 0.05), ESR (P < 0.05), 24-h urinary protein (P < 0.001), and negatively correlated with serum albumin (P < 0.05). HMGB1 and IFN-γ may contribute to the generation of lupus nephritis and may be a potential role for therapies targeting cytokines and HMGB1 in preventing or limiting lupus nephritis in the vulnerable SLE patients.

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Limitations

The limitations of this study were with regard to patient numbers and clinical events.

Funding

The authors received no financial support for the research and/or authorship.

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The authors have no conflict of interest.

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Authors and Affiliations

  1. Clinical and Chemical Pathology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt

    Hoiyda A. Abdel Rasol

  2. Faculty of Applied Medical Sciences, Taibah University, Medina, Kingdom of Saudi Arabia

    Hoiyda A. Abdel Rasol

  3. Rheumatology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

    Wafaa Gaber

  4. Department of Biochemistry, Research Institute of Ophthalmology, Cairo, Egypt

    Margeret A. Aziz

  5. Microbiology Department, Faculty of Medicine, Ismailia University, Fayoum, Egypt

    Abeer Galal El-Din Ahmed Rabie

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  1. Hoiyda A. Abdel Rasol
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  2. Wafaa Gaber
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  3. Margeret A. Aziz
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  4. Abeer Galal El-Din Ahmed Rabie
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Correspondence to Hoiyda A. Abdel Rasol.

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Rasol, H.A.A., Gaber, W., Aziz, M.A. et al. Elevated high-mobility group box1 level is associated with alterations of interferon gamma in Egyptians with lupus nephritis. Comp Clin Pathol 24, 989–994 (2015). https://doi.org/10.1007/s00580-014-2018-3

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  • DOI: https://doi.org/10.1007/s00580-014-2018-3

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