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Diagnostic performance of magnifying endoscopy with narrow-band imaging in differentiating neoplastic colorectal polyps from non-neoplastic colorectal polyps: a meta-analysis

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Abstract

Colorectal polyps are commonly seen in colonoscopy and the management of neoplastic polyps and non-neoplastic polyps are different. It is necessary to distinguish neoplastic polyps from non-neoplastic polyps in real-time. Therefore, we conducted a meta-analysis to assess the diagnostic accuracy of magnifying endoscopy with narrow-band imaging (ME-NBI) in diagnosing neoplastic colorectal polyps from non-neoplastic colorectal polyps. PubMed and EMBASE were searched for trials that used magnifying endoscopy with ME-NBI for diagnosing neoplastic colorectal polyps. Sixteen articles and 20 fourfold tables were obtained. Sensitivity (Sen), specificity (Spe), positive likelihood ratios (+ LRs), negative likelihood ratios (− LRs) and diagnostic odds ratios (DORs) were calculated. A summary receiver-operating characteristic (SROC) curve was constructed, and the area under the ROC curve (AUC) was calculated. We performed subgroup analyses based on polyp size and assessment criteria: (1) According to data extracted from 20 fourfold tables, the pooled Sen and Spe of ME-NBI for diagnosing neoplastic colorectal polyps < 10 mm were 0.94 (95% CI 0.92–0.95) and 0.76 (95% CI 0.72–0.80),respectively. The pooled Sen and Spe of ME-NBI for diagnosing all neoplastic polyps were 0.98 (95% CI 0.98–0.99) and 0.88 (95% CI 0.85–0.90), respectively. (2) Data pertaining to the following three assessment methods were analysed from 15 fourfold tables: surface pattern (SP), vessel pattern (VP) and the combination of SP and VP. The AUCs for these assessment criteria were 0.9533, 0.9518 and 0.9954, respectively. Conclusions were made that ME-NBI has high diagnostic accuracy in diagnosing neoplastic colorectal polyps based on the combination of SP with VP and is helpful in making real-time diagnoses.

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Acknowledgements

This article is supported by the Science and Technology Department of Sichuan Province for Scientific Research in China (Nos. 2014SZ0002-2 and 2015SZ0123).

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  1. Department of Gastroenterology, West China Hospital of Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, Sichuan Province, China

    Tian-Jiao Guo, Wei Chen, Yao Chen, Jun-Chao Wu, Yi-Ping Wang & Jin-Lin Yang

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Correspondence to Jin-Lin Yang.

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Tian-Jiao Guo, Wei Chen, Yao Chen, Jun-Chao Wu, Yi-Ping Wang, Jin-Lin Yang declare that they have no conflict of interest.

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Guo, TJ., Chen, W., Chen, Y. et al. Diagnostic performance of magnifying endoscopy with narrow-band imaging in differentiating neoplastic colorectal polyps from non-neoplastic colorectal polyps: a meta-analysis. J Gastroenterol 53, 701–711 (2018). https://doi.org/10.1007/s00535-018-1436-4

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