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Different effects of dietary factors on reflux esophagitis and non-erosive reflux disease in 11,690 Korean subjects

  • Original Article—Alimentary Tract
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Abstract

Background

Although dietary factors seem to be associated with gastroesophageal reflux symptoms, their effects on reflux esophagitis and non-erosive reflux disease (NERD) are unclear. We evaluate dietary effects on NERD and reflux esophagitis.

Methods

A total of 11,690 health check-up persons completed questionnaires for reflux symptoms and 3-day recordings for dietary intake and underwent esophagogastroduodenoscopy from 2004 to 2008. Multiple logistic regression with odds ratio (OR) and 95% confidence interval (CI) was used to evaluate the relationship of dietary components with NERD or reflux esophagitis.

Results

Prevalence of NERD and reflux esophagitis was 7.7 and 7.2%, respectively. In adjusted analysis, highest quartile of beans (OR 0.78, 95% CI 0.64–0.95), 3rd quartile of vegetables (OR 0.74, 95% CI 0.60–0.91), 4th quartile of fruit (OR 0.78, 95% CI 0.64–0.95), 4th quartile of egg (OR 0.78, 95% CI 0.64–0.96), and 3rd quartile of fish (OR 0.80, 95% CI 0.66–0.98), and 4th quartile of milk (OR 0.78, 95% CI 0.65–0.94) reduced NERD. Reflux esophagitis had no association with food groups, whereas it was related with men, absence of H. pylori, hiatal hernia, BMI, and total energy intake. Furthermore, dietary effect on NERD was similar in men and women, whereas highest tertile of potato (OR 1.91) and milk (OR 1.87) increased reflux esophagitis only in women.

Conclusions

While many food groups affected NERD, reflux esophagitis was associated with BMI and total energy intake rather than dietary component. These results may suggest different approaches toward dietary management of NERD and reflux esophagitis.

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Acknowledgements

The authors thank Hyun Hee Kang, Kyoung A Ryu, and Min Kyong Yoo for acquiring the nutritional data.

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Authors and Affiliations

  1. Kyungpook National University Medical Center, Kyungpook National University School of Medicine, 807 Hoguk-ro, Buk-gu, Daegu, 702–210, South Korea

    Su Youn Nam & Kum Hei Ryu

  2. Center for Cancer Prevention and Detection, National Cancer Center, Goyang, South Korea

    Su Youn Nam & Bum Joon Park

  3. Department of Clinical Nutrition, National Cancer Center, Goyang, South Korea

    Yeong-Ah Cho

  4. Center for Gastric Cancer, National Cancer Center, Goyang, South Korea

    Il Ju Choi & Young-Woo Kim

  5. Cancer Biostatistics Branch, National Cancer Center, Goyang, South Korea

    Sohee Park

  6. Department of Biostatistics Graduate School of Public Health, Yonsei University, Seoul, South Korea

    Sohee Park

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  1. Su Youn Nam
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Correspondence to Su Youn Nam.

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Nam, S.Y., Park, B.J., Cho, YA. et al. Different effects of dietary factors on reflux esophagitis and non-erosive reflux disease in 11,690 Korean subjects. J Gastroenterol 52, 818–829 (2017). https://doi.org/10.1007/s00535-016-1282-1

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  • DOI: https://doi.org/10.1007/s00535-016-1282-1

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