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Summary of evidence on comprehensive healthcare for chemotherapy-induced peripheral neuropathy in cancer patients

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Abstract

Objective

This paper aims to provide an evidence-based summary of the most effective strategies for comprehensive healthcare of chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients.

Method

Following the “6S” model, relevant evidence on CIPN management was collected from reputable evidence-based resource websites and databases nationally and internationally. The included articles were evaluated for methodological quality, and evidence was extracted using the Australian JBI Evidence-based Health Care Center’s literature evaluation standard (2016 edition).

Results

A total of 60 articles were included in this study, comprising 2 guidelines, 5 expert consensus statements, and 53 systematic reviews. The findings of these articles were summarized across 7 dimensions, including risk factor screening, assessment, diagnosis, prevention, treatment, management, and health education, resulting in the identification of 42 relevant pieces of evidence.

Conclusions

This study provides a comprehensive synthesis of evidence-based recommendations for managing CIPN in cancer patients, offering guidance for healthcare professionals engaged in clinical practice. However, when implementing these recommendations, it is crucial to consider the individual patient’s clinical circumstances, preferences, and expert judgment, ensuring feasibility and applicability in real-world clinical settings.

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Data availability

All relevant data are included in this article. Further inquiries can be directed to the corresponding author.

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Acknowledgements

We express our gratitude to the Sichuan University Library for providing us with database resources for searching literature.

Funding

This study was supported by the Nursing Department of West China Second University Hospital, Sichuan University (HLBKJ202022).

Author information

Authors and Affiliations

  1. Department of Radiation Therapy and Chemotherapy for Cancer Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

    Xin Dan, Ya-Lin He & Ya-Lin Tian

  2. Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, 610041, Sichuan, China

    Xin Dan, Ya-Lin He, Ya-Lin Tian, Yan Huang & Jian-Hua Ren

  3. Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

    Yan Huang

  4. Department of Obstetrics and Gynecology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China

    Jian-Hua Ren

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  1. Xin Dan
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  4. Yan Huang
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Contributions

Study conceptualisation, Xin Dan, Yan Huang, and Jian-Hua Ren. Methodology development, Xin Dan, Ya-Lin He, Ya-Lin Tian, and Yan Huang. Data curation, Xin Dan, Ya-Lin He, Ya-Lin Tian and Jian-Hua Ren. Formal analysis, Xin Dan and Jian-Hua Ren. Writing-reviewing and editing, Xin Dan, Yan Huang, and Jian-Hua Ren. Supervision, Yan Huang, and Jian-Hua Ren. Project administration, Xin Dan. The authors read and approved the final manuscript.

Corresponding authors

Correspondence to Yan Huang or Jian-Hua Ren.

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An ethics statement is not required for this study as it solely relies on published literature and does not involve direct research on humans or animals. Consequently, ethical considerations do not arise.

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Dan, X., He, YL., Tian, YL. et al. Summary of evidence on comprehensive healthcare for chemotherapy-induced peripheral neuropathy in cancer patients. Support Care Cancer 32, 264 (2024). https://doi.org/10.1007/s00520-024-08466-7

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