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Compression therapy using surgical gloves is ineffective for the prevention of vincristine-induced neuropathy in patients with malignant lymphoma

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Abstract

Purpose

Vincristine (VCR) often induces peripheral neuropathy (PN) as an adverse event. Currently, there is no consensus on the prevention of vincristine-induced PN (VIPN). In this study, we aimed to investigate the efficacy of compression therapy using surgical gloves for preventing VIPN.

Methods

Patients with malignant lymphoma (vincristine-naïve) who were receiving chemotherapy with cyclophosphamide, doxorubicin, VCR, and prednisolone, with or without rituximab, every 3 weeks for six cycles were eligible. For every VCR infusion, each patient wore two one-size-smaller gloves on one hand (study hand) for 90 min. The other hand was left bare (control hand). PN was assessed at each treatment using the Common Terminology Criteria for Adverse Events ver. 4.0.

Results

Fifty-one patients with malignant lymphoma were enrolled and 44 were evaluated. At 1 month after treatment, the occurrence rates of grade ≥ 2 sensory PN were 13.6 and 13.6% in the study and control hands, respectively (p = 1.0), and those of grade ≥ 2 motor PN were 15.9 and 15.9% in the study and control hands, respectively (p = 1.0).

Conclusion

Compression therapy using surgical gloves showed no significant effect for the prevention of VIPN.

Trial registration

November 1, 2018, National University Hospital Council of Japan (UMIN 000034145).

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Data Availability

The data can be made available from the corresponding author upon reasonable request.

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Acknowledgements

We thank the many nurses and patients of Hitachi General Hospital.

Funding

No funding was received to assist with the preparation of this manuscript.

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Authors and Affiliations

  1. Diabetes and Hematology Division, NHO Kanmon Medical Center, 1-1, Sotouracho, Shimonoseki-City, Yamaguchi, 752-8510, Japan

    Takuya Suyama

  2. Hematology and Oncology Division, Hitachi General Hospital, 2-1-1 Jonancho, Hitachi-City, Ibaraki, 317-0077, Japan

    Yuri Tsuboi, Misayo Shimizu, Akihiro Kuroda, Masanori Seki & Atsushi Shinagawa

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  1. Takuya Suyama
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  2. Yuri Tsuboi
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  3. Misayo Shimizu
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  4. Akihiro Kuroda
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  5. Masanori Seki
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  6. Atsushi Shinagawa
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Contributions

All authors contributed to study conception and design. Data preparation and analysis were performed by Takuya Suyama. Data collection was performed by all authors. The first draft of the manuscript was written by Takuya Suyama, Yuri Tsuboi, Misayo Shimizu. Akihiro Kuroda, Masanori Seki, and Atsushi Shinagawa commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Takuya Suyama.

Ethics declarations

Ethics approval

Approval was obtained from the ethics committee of Hitachi General Hospital. The procedures used in this study adhere to the tenets of Declaration of Helsinki.

Consent to participate

Informed consent to participate was obtained from all participants prior to intervention commencement.

Consent for publication

Informed consent to publish data was obtained from all participants.

Competing interests

The authors declare no competing interests.

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Suyama, T., Tsuboi, Y., Shimizu, M. et al. Compression therapy using surgical gloves is ineffective for the prevention of vincristine-induced neuropathy in patients with malignant lymphoma. Support Care Cancer 32, 173 (2024). https://doi.org/10.1007/s00520-024-08389-3

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