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Effects of a 12-week exercise-based intervention on weight management in overweight or obese breast cancer survivors: a randomized controlled trial

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Abstract

Purpose

Breast cancer survivors face dual challenges: long-term sequelae of treatment and the risk of recurrent disease. Furthermore, obesity and a sedentary lifestyle can complicate both challenges. We aimed to assess the effect of a 12-week exercise-based weight-management program in overweight/obese breast cancer survivors.

Methods

A two-arm, single-blinded, randomized controlled trial was conducted among 60 overweight/obese, stage 0–III breast cancer survivors. During the 12-week program, the intervention group received weekly information support, fortnightly exercise prescriptions, including aerobic and resistance exercises to perform at home, and one dietary instruction. The control group received information support about weight management and exercise. Weight, body composition, and physical fitness data were collected at baseline, postintervention, and the 3-month follow-up.

Results

The intervention group showed significant improvements in body weight and all adiposity indices, including body mass index, waist circumference, and %body fat, in comparison with baseline (P < 0.001) and the control group (P < 0.05). Both groups showed no significant changes in fat-free mass during the 6-month period (P > 0.05). International Physical Activity Questionnaire scores and left grip strength increased significantly in the intervention group in comparison with the baseline (P < 0.01) and the control group (P < 0.05). Right grip strength, lower-body strength, and aerobic endurance showed no significant intergroup differences (P > 0.05).

Conclusions

A combination of exercise prescription and weight-loss interventions yielded clinically meaningful weight loss in overweight/obese breast cancer survivors. These findings may facilitate the incorporation of home-based exercise and weight management into breast cancer treatment and survivorship care.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This study was supported by the Beijing Natural Science Foundation of China (no. 7222008).

Author information

Authors and Affiliations

  1. School of Nursing, Capital Medical University, No. 10, Xitoutiao, You An Men Wai, Fengtai District, Beijing, China

    Fu-Yun Zhao, Jun-E Liu, Lu Chen, Jia-Gui Liang, Yu Liu, Ruo-Lin Li & Hai-Rong Chen

  2. Department of Breast Surgery, Yantai Yuhuangding Hospital, Shandong, China

    Xiao-Ming Fang

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  1. Fu-Yun Zhao
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  2. Jun-E Liu
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Contributions

Fuyun Zhao: conceptualization; methodology; formal analysis; investigation; data curation; writing—original draft; writing—review and editing. Jun-E Liu: conceptualization; methodology; supervision; writing—review and editing; project administration; funding acquisition. Xiaoming Fang: project administration, investigation, data curation. Lu Chen: methodology, supervision, writing—review and editing. Jiagui Liang: methodology, supervision, writing—review and editing. Yu Liu: supervision, writing—review and editing. Ruolin Li: investigation. Hairong Chen: investigation.

Corresponding author

Correspondence to Jun-E Liu.

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Ethics approval

Approval was obtained from the Medical Ethics Committee of Capital Medical University (Z2023SY035). The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Informed consent was obtained from all of the participants in this study.

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The authors declare no competing interests.

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Zhao, FY., Liu, JE., Fang, XM. et al. Effects of a 12-week exercise-based intervention on weight management in overweight or obese breast cancer survivors: a randomized controlled trial. Support Care Cancer 32, 98 (2024). https://doi.org/10.1007/s00520-023-08300-6

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