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Photobiomodulation: a promising innovative approach for preventing oral mucositis in patients undergoing hematopoietic stem cell transplantation

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Abstract

Purpose

This single-center retrospective study aims to assess the feasibility, safety, and tolerability of CareMin650, a new photobiomodulation device, for both preventing oral mucositis (OM) and reducing its severity in the setting of hematopoietic stem cell transplantation (HCT).

Methods

Patients who underwent autologous HCT for hematological malignancies between November 2020 and October 2021 could be included. Prophylactic photobiomodulation (PBM) was used daily from day 1 of conditioning until the day of neutrophil recovery at a dose of 3 J/cm2. Curative PBM was started at a dose of 6 J/cm2 when at least one grade 1 OM had occurred. For each OM case, time of onset, National Cancer Institute-Common Terminology Criteria for Adverse Events (NCI-CTCAE) v5.0 grade for OM, analgesic dose, and time to resolution were reported.

Results

Twenty-five consecutive patients were included. The median age was 58 years (range, 39–74) and 14 (56%) were male. Twenty-one patients (84%) received a high-dose melphalan conditioning regimen for multiple myeloma, and 4 (16%) patients received BEAM conditioning for aggressive lymphoma. A total of 178 CareMin650 sessions were performed, with a median of 7 days of application (range, 4–12), with no device-related adverse events (AEs). According to the NCI-CTCAE v5.0 scale, 76% (19 of 25) of patients presented grade 0 or 1 mucositis (no ulcers), five patients (20%) developed small ulcers (grade 2), and only one patient developed grade 4 mucositis. Satisfaction rates were high among patients and users.

Conclusion

Photobiomodulation provides excellent safety and tolerance, as well as promising efficacy, both as a preventive and curative strategy, in patients undergoing autologous HCT.

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Acknowledgements

The authors acknowledge NeoMedLight, 90 rue Frédéric Fays, 69100 Villeurbanne, France, and Cell Therapies Research & Services (CTRS), 63 rue de l’Est, 92100 Boulogne-Billancourt, France, for their generous and continuous support of this research work. The authors also thank the clinical teams who cared for the study patients and for their dedication to this study.

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Authors and Affiliations

  1. Centre de Recherche Saint-Antoine (CRSA), INSERM, Sorbonne Université, 75012, Paris, France

    Nicolas Stocker, Virginie Baltes, Solal Bellaiche, Flora Brouillard, Nadia Belmoufid, Zoé Van de Wyngaert, Laure Ricard, Anne Banet, Florent Malard, Remy Duléry, Mohamad Mohty & Eolia Brissot

  2. Service Hématologie Clinique Et Thérapie Cellulaire, Hôpital Saint-Antoine, AP-HP, 184 rue du Faubourg Saint-Antoine, 75012, Paris, France

    Nicolas Stocker, Céline Rousseau, Agnès Bonnin, Zoé Van de Wyngaert, Laure Ricard, Anne Banet, Florent Malard, Remy Duléry, Mohamad Mohty & Eolia Brissot

Authors
  1. Nicolas Stocker
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  2. Virginie Baltes
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  3. Solal Bellaiche
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  11. Florent Malard
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  13. Mohamad Mohty
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  14. Eolia Brissot
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Contributions

NS and EB designed the study, NS collected the data, and all authors recruited patients. NS and EB prepared the manuscript for publication. All authors analyzed the data, reviewed the manuscript, and agreed to its submission for publication.

Corresponding author

Correspondence to Nicolas Stocker.

Ethics declarations

Ethics approval

All study procedures complied with the ethical standards and the guidelines of the 1964 Declaration of Helsinki. There were no invasive procedures planned for human beings during the study period.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

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Not applicable.

Competing interests

The authors declare no competing interests.

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Stocker, N., Baltes, V., Bellaiche, S. et al. Photobiomodulation: a promising innovative approach for preventing oral mucositis in patients undergoing hematopoietic stem cell transplantation. Support Care Cancer 30, 8211–8216 (2022). https://doi.org/10.1007/s00520-022-07280-3

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  • DOI: https://doi.org/10.1007/s00520-022-07280-3

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