Abstract
Purpose
To quantify financial toxicity of female patients with breast cancer in China and investigate its factors and patients’ coping strategies.
Methods
The Comprehensive Score for Financial Toxicity (COST) is defined by using a structured questionnaire containing 12 items measuring perceived affordability of healthcare services, with the range of scoring of which being from 0 to 44 (higher score indicates lower financial toxicity). From January to March 2021, a total of 664 female patients diagnosed with stage 0–IV breast cancer were recruited from 33 public tertiary cancer hospitals located in 31 provinces of China. Multivariate linear regression models were used.
Results
The median age of patients was 48 years (range: 26–84 years), and 62.04% lived in urban areas. The median COST score was 21.00 (interquartile range: 15–26). Older age, higher household income, and better self-reported health status were associated with lower financial toxicity, while a bigger household size, being retired or unemployed, stage IV cancer, and a history of targeted therapy were associated with higher financial toxicity (all P < 0.05). Nearly half of the patients reported using at least one coping strategy, including considering quitting treatment, delaying treatment, and failing to take medicine or attend medical visits as instructed. The people with increased financial toxicity seem to adopt more coping strategies.
Conclusions
Financial toxicity and coping strategies are common among Chinese women with breast cancer. An understanding of the factors regarding financial toxicity may help oncologists and policy-makers identify at-risk patients and develop targeted interventions.
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Introduction
In 2020, female breast cancer surpassed lung cancer as the leading cause of global cancer incidence, and it is the most frequently diagnosed cancer among Chinese women with more than 800 new cases each day [1, 2]. Due to the development of innovative treatments involving gene therapy, targeted therapy, and conservative surgery and the advances of overall healthcare, the health outcomes of patients with breast cancer have improved; however, treatment-related costs continue to increase [3]. A multicenter cross-sectional study including patients from 13 provinces in China reported that the average medical expenditure for a female patient with breast cancer was US $7,527 in 2014, which was more than twice the amount of the average disposable income of Chinese residents (US $3,284) [4]. Although social medical insurance of universal coverage has been built in China since 2009, the proportion of out-of-pocket expenditure in total health expenditure is still more than 25% now, with a higher proportion for cancer patients due to deficient coverage of certain drugs and procedures [5, 6]. The incidence of catastrophic health expenditure (CHE) for breast cancer was 31% (set the threshold of CHE at 40% of average household income) [7]. In China, the onset age of breast cancer is low, and patients are likely to have late-stage cancer due to poor awareness of regular screening protocols [8]. These factors may aggravate the financial hardship of female patients with breast cancer in China.
The financial hardship associated with clinical treatments is gaining recognition [9]. Previous studies have suggested that financial hardship is related to a decrease in treatment adherence and health-related quality of life and an increase in adverse symptoms and depression [10,11,12,13,14,15]. As a diagnosis of cancer is typically followed by a reduced work schedule and expensive treatments, many individuals or families are forced to use passive coping strategies, such as reducing non-medical expenses and basic healthcare expenses and acquiring loans [16, 17]. As financial burdens and their adverse effects are being gradually recognized, intervention strategies have been proposed including improving transparency regarding the costs of treatment, enhancing cost-based communication between patients and oncologists, and offering financial assistance [18].
Financial toxicity refers to the subjective financial distress and objective financial burden of medical care [19]. To quantify financial toxicity, the Comprehensive Score for Financial Toxicity (COST) instrument was developed [20, 21] and has been used and validated in several countries. Financial toxicity in patients with cancer has been associated with age [22, 23], income [24, 25], insurance [16], education [23, 24], out of pocket expenses [16], work status [21, 26], household savings [26], and disease and treatment profiles [16, 27]. The only previous study that investigated financial toxicity in Chinese female patients with breast cancer focused on patients with stage 0–III breast cancer treated at one tertiary cancer center [25]. More studies including a more representative sample are needed to further the understanding of this field.
This study aimed to quantify the financial toxicity of stage 0–IV breast cancer in female patients in China using the validated COST instrument and to explore the factors underlying high financial toxicity. The relationships between financial toxicity and coping strategies are also investigated in this study. By identifying the population most at risk for financial toxicity, this study may lead to policy changes and early interventions for those in need.
Materials and methods
Study design
This cross-sectional study based on a national inpatient survey was part of the external evaluation of the National Healthcare Improvement Initiative in 2021 and included patients from 33 public tertiary cancer hospitals in 31 provinces of China. The cancer hospitals included in this study treat a large number of patients with severe and complicated diseases and represent a relatively high technical level of diagnoses and treatments in China.
At least 150 inpatients diagnosed with any type and any stage of cancer were continuously recruited from each hospital between January and March 2021. Each patient was interviewed by the investigators. All of the patients were nearing discharge at the time of the interview, and those who agreed to participate in the study were asked to complete an electronic questionnaire. The investigators assisted patients who were unable to complete the questionnaire on their own. This study was approved by the Ethics Committee of Institute of Medical Biology of Chinese Academy of Medical Sciences (IPB-2020–23) and all patients provided written informed consent for their participation in the study.
Patients
A total of 5417 patients were surveyed. Female patients aged ≥ 18 years with a diagnosis of breast cancer (n = 664; 12.3%) were eligible for inclusion in this study. Patients who did not undergo treatment (n = 6), those involved in clinical trials (n = 27), and those with concomitant cancers of different types (n = 4) were excluded from the study as the financial burden of these patients could vary significantly from those undergoing regular treatments for breast cancer. The final analysis included 627 patients (Fig. 1).
Variables and outcomes
In this study, financial toxicity was assessed using the COST questionnaire, which has been validated and used internationally and in China [20, 21, 28,29,30,31,32]. The COST questionnaire consists of 12 items that are rated using a 5-point Likert scale. The recall period of the COST questionnaire is 7 days. It is designed to measure the financial toxicity of patients aged 18 years and older. The total score of the COST questionnaire ranges from 0 to 44 points, with lower scores indicating worse financial conditions and higher levels of financial toxicity. The original English version of the COST questionnaire and the scoring guidelines are available online (www.facit.org/measures/FACIT-COST). The Chinese version can be obtained from the official website upon request (Supplementary A1).
The coping strategies of patients facing financial toxicity were designed based on frameworks and previous studies [17, 18, 33, 34]. They were collected by a survey question “have you ever taken the following actions due to financial difficulties,” followed by seven items (response “yes” or “no”):
-
1.
once considered quitting treatment;
-
2.
have delayed treatment for more than seven days;
-
3.
have failed to take medicine as instructed;
-
4.
have failed to attend medical visits as instructed;
-
5.
have reduced spending on leisure activities, such as shopping or travelling;
-
6.
have reduced spending on basic health services, such as clinic visits or vaccinations;
-
7.
have borrowed money or acquired a loan due to illness.
The patients’ demographic (age, residency, ethnicity, marital status, education, and household size), economic (annual household income, work status, and medical insurance), and clinical (duration since diagnosis, cancer stage, self-reported health status, and therapies) characteristics were collected using a study-specific questionnaire based on relevant surveys that was validated by consultations with multidisciplinary experts and a small-scale pilot survey [27, 35].
Statistical analysis
Descriptive statistics were used to summarize the patients’ baseline characteristics (Table 1). Continuous variables were presented as median and interquartile range (IQR) or mean and standard deviation (SD). Categorical variables were presented as number and percentage. Significant covariates identified in a univariate linear regression analysis (P ≤ 0.10) and covariates identified by other studies to be of significance (age and surgery) were included in the multivariate linear regression analyses [36, 37]. All of the variance inflation factors (VIF) for the multivariate liner regression analysis were less than two.
In analysis of coping strategies, patients were divided into different financial toxicity groups based on median COST score [16, 25]. The patients’ coping strategies were presented as a number and percentage in each financial toxicity group. Pearson’s chi-square test was used to compare the coping strategies between the two groups with different COST scores.
For all analyses, a two-tailed P value < 0.05 was considered statistically significant. All statistical analyses were conducted with Stata/SE 15.0 software (Stata Corp LP, College Station, TX, USA).
Sensitivity analysis
To verify the robustness of the result of determinants of financial toxicity, sensitivity analysis was performed by repeating the multivariate linear regression analysis with participants of a known cancer stage.
Results
Patient characteristics
The mean COST score was 20.99 (SD: 9.323) and the median COST score was 21.00 (IQR: 15–26). The mean patient age was 48.71 years (SD: 10.591 years), and 262 patients (42.79%) had Urban Employees Basic Medical Insurance (UEBMI) while 338 patients (53.91%) had Urban and Rural Residents Basic Medical Insurance (URBMI) (Table 1). Nearly half of the patients (48.80%) had a duration since diagnosis of less than one year. Stage 0–I cancer was diagnosed in 20.73% of patients, stage II in 20.10%, stage III in 14.04%, and stage IV in 18.50%. The stage was unknown in 167 (26.63%) patients. Overall, 78.31% of patients underwent surgical treatment, 20.73% underwent targeted therapy, and 29.03% underwent radiotherapy.
Determinants of financial toxicity
The patients’ residency, education, household size, annual household income, work status, medical insurance, duration since diagnosis, stage, self-reported health status, history of targeted therapy, and history of radiotherapy were associated with financial toxicity in univariate analyses (all P < 0.05) (Table 2).
After adjusting for possible confounding variables, older age, higher annual household income, and better self-reported health status were associated with lower financial toxicity (all P < 0.05) (Table 2). Per year increase in age was associated with an average increase in the COST score of 0.10 points (95% confidence interval (CI): 0.03 to 0.17, P = 0.004). Annual household income of ¥60,000–120,000 and ≥ ¥120,000 increased the COST score by 3.36 points (95% CI: 1.38 to 5.34, P = 0.001) and 6.30 points (95% CI: 4.03 to 8.57, P < 0.001), respectively, compared to an annual household income < ¥30,000. Self-reported health status of moderate or better were associated with COST scores that were increased by 1.72 points (95% CI: 0.16 to 3.28, P = 0.031) and 3.77 points (95% CI: 2.06 to 5.48, P < 0.001), respectively.
Smaller household size, being retired or unemployed, advanced stage, and having a history of targeted therapy were associated with lower COST scores (higher financial toxicity). A household size ≥ 4 was associated with an average 1.45-point (95% CI: − 2.81 to − 0.09, P = 0.037) decrease in the COST score. The average COST score of patients who were retired or unemployed was 2.08 points (95% CI: − 3.57 to − 0.59, P = 0.006) lower than that of patients who were employed. Patients with stage IV breast cancer scored 4.35 points (95% CI: − 6.64 to − 2.06, P < 0.001) lower than patients with stage 0–I breast cancer, and those who did not know their stage scored 2.28 points (95% CI: − 4.23 to − 0.33, P = 0.022) lower than patients with stage 0–I breast cancer. Patients who underwent targeted therapy averaged 2.36 points (95% CI: − 3.98 to − 0.74, P = 0.004) lower than those who had not. Patients with URBMI were more likely to have increased financial toxicity risk than those with UEBMI (coefficient: − 1.48, 95% CI: − 3.16 to 0.20, P = 0.083). Patients whose duration since diagnosis was 1–2 years (coefficient: − 1.63, 95% CI: − 3.33 to 0.07, P = 0.061) or ≥ 2 years (coefficient: − 1.49, 95% CI: − 3.25 to 0.26, P = 0.095) had increased financial toxicity compared with those whose duration since diagnosis was ≤ 1 year (Table 2).
Patients’ coping strategies and financial toxicity
Nearly half of the patients (48.01%) reported using at least one coping strategy (Table 3). Overall, 258 (41.15%) patients reported decreasing spending on leisure activities such as shopping or travelling, and 106 (16.91%) reported decreasing their spending on basic health services such as clinic visits and vaccinations. A total of 133 (21.21%) patients borrowed money from relatives and friends or acquired a loan from a bank. Patients with COST scores below the median score (those with high financial toxicity) were more likely to use coping strategies (all P < 0.001).
As the number of coping strategies used by a patient increased from zero to seven, the percentage of patients with high financial toxicity increased from 29.5 to 100.0% (Fig. 2). The median COST score decreased as the number of coping strategies used increased, as the median COST score for patients using zero coping strategies was 24.5 (IQR: 20–31) and that of patients using seven coping strategies was 1 (IQR: 0–4).
Sensitivity analysis
A total of 460 patients knew their cancer stage. A regression analysis including these patients yielded similar results as the analysis including all patients (Supplementary A2).
Discussion
This study identified factors and coping strategies associated with financial toxicity in female patients with breast cancer using the COST score. Older age, higher household income, and better self-reported health status were associated with lower financial toxicity, while bigger household size, being retired or unemployed status, stage IV breast cancer, and a history of targeted therapy were associated with higher financial toxicity.
The level of financial toxicity of patients with breast cancer in China
The multicenter design of this study allowed for the observation of financial toxicity in a more geographically and clinically diverse population in China. A previous study reported financial toxicity of 166 patients with stage 0–III breast cancer treated at a single hospital [25]. Our study includes patients with stage 0–IV breast cancer patients treated at 33 hospitals. The median COST score was a little lower in this study than the score of 22 in the previous study [25], which may be attributed to the inclusion of patients with stage IV breast cancer in this study (stage IV: 18.50%, median COST score: 17). The median COST score reported in a study of financial toxicity in patients with breast cancer who underwent lumpectomy or mastectomy in the USA was 30 and the median COST score reported in patients with metastatic breast cancer was 22, which are higher than in our study [16, 38]. The comparatively higher level of financial toxicity among Chinese patients might be attributed to inadequate coverage of medical insurance for cancer treatment cost and the low affordability of advanced drugs and procedures given that China is still a middle-income country with a big population. [39, 40]. Besides, in the USA, median scores of financial toxicity among cancer survivors were mostly between 23 and 29, and financial toxicity of patients with breast cancer was relatively lower than patients with other types of cancer, such as multiple myeloma and lung cancer due to lower medical costs [21, 23, 27]. These indicate greater economic burden for Chinese cancer survivors.
Factors associated with financial toxicity
In this study, age and household size were associated with financial toxicity. Patients with increased age had a lower probability of having financial toxicity, which is consistent with the results of previous studies [22, 41,42,43]. Younger adults may not have additional resources such as retirement funds or home equity to ease their financial burden [44]. Younger adults also tend to have fewer savings, and an association between less household savings and higher financial toxicity has been reported [11, 26]. Younger adults also have more financial responsibilities than older adults, including the need to support family members and pay for housing and other bills, resulting in increased financial needs [45]. In this study, a larger household size was associated with higher financial toxicity in the multivariate models among patients with breast cancer, which is consistent with the findings of previous studies [41, 46, 47].
Economic factors are important predictors of financial burden for patients with cancer [47]. In this study, household income was a protective factor of financial toxicity. Previous studies reported an association between being retired or unemployed and higher financial toxicity [21, 47] Different medical insurance types showed no association with financial toxicity. Chinese government launched a new round of health system reform in 2009 to provide affordable and equitable basic healthcare for all, the gap of different medical insurance types regarding service packages covered and the drugs covered was greatly narrowed [5].
The effects of disease duration, disease stage, self-reported health status, and treatment methods (including surgery, radiotherapy, and targeted therapy) on financial toxicity were also investigated in this study. Better self-reported heath status was a protective factor for patients in this study. A previous study regarding the correlation between COST scores and self-reported health in gynecologic oncology patients reported that worse self-reported health is correlated with greater financial toxicity (r = 0.47; P < 0.001) [34]. Advanced cancer stage was significantly associated with increased financial toxicity in this study, which is similar to previously reported results regarding financial toxicity in adult females with breast cancer who underwent a lumpectomy or mastectomy [16]. Increased financial toxicity was also observed among patients with an unknown breast cancer stage. In China, a patient’s family tended to conceal the details of the disease from the patient, especially when the disease is severe [48, 49]. Therefore, patients who do not know their stage may have a higher probability to suffer advanced stage cancer. A history of targeted therapy increased the risk of financial toxicity in this study. These findings indicate that multiple policies or actions should be taken by the government and society to relieve the financial difficulties faced by patients with breast cancer, especially those who are younger adults, unemployed, suitable for targeted therapy, and with bigger household size, lower income and worse self-reported health.
Financial toxicity and coping strategies
Increased financial toxicity resulted in the use of multiple coping strategies, as indicated by the association between decreased COST scores and increased number of coping strategies. A previous study reported that patients prioritized affordability or maintaining functional independence when making treatment decisions [44]. Sixty-eight percent of patients with high financial toxicity and nearly 30% of patients with low financial toxicity reporting using at least one coping strategy, which includes reducing their spending on basic health services such as clinic visits and vaccinations, quitting treatment, delaying treatment, and failing to take medicine or attend medical visits as instructed. These results indicate patients with financial difficulties tend to withdraw from treatment plans or avoid seeking necessary healthcare, which might cause adverse effects on their recovery and health outcome [15].
Strengths and limitations
Our study was based on a large sample with a diversity of geographic locations and multicenter collaboration in China. Our findings identified the common coping strategies of patients with breast cancer who faced financial toxicity. Patients with higher financial toxicity tended to pause or postpone appropriate treatments and reduce their basic healthcare and basic living expenses. The results of this study can help identify patients with a high-risk financial toxicity, and are useful for designing targeted interventions.
However, this study has some limitations. First, the nature of cross-sectional design limited the power to determine a causal relationship. Longitudinal research will be considered to explore the causal mechanism in the future. Second, the clinical information was self-reported by the patients which may have recall bias, although the magnitude of the bias might be small because the patients were interviewed in hospitals close to discharge. In addition, approximately one-fourth of the patients in this study did not know their cancer stage. A sensitivity analysis was used to assess whether the exclusion of this population would significantly affect the results. And results of the sensitivity analysis were robust. Third, travel distance between home and treatment center is an important factor related to indirect costs and financial toxicity. Our survey did not collect the data and it could be further explored in future studies. Finally, this study only focused on female patients with breast cancer in tertiary cancer hospitals, which usually took patients of progressive stage. Future studies should include more hospital and disease types.
Conclusion
In conclusion, this national cross-sectional study that quantified financial toxicity in female patients with stage 0–IV breast cancer in China revealed that financial toxicity and coping strategies are common among these patients. Increased financial toxicity is associated with the use of more coping strategies. An understanding of the factors associated with financial toxicity may help oncologists and policy-makers identify patients at risk for financial toxicity and develop targeted interventions.
Data availability
The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.
References
Cao M, Li H, Sun D et al (2020) Cancer burden of major cancers in China: a need for sustainable actions. Cancer Commun (Lond) 40(5):205–210. https://doi.org/10.1002/cac2.12025
Sung H, Ferlay J, Siegel RL et al (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660
Shi JF, Shi CL, Yue XP et al (2016) Economic burden of cancer in China during 1996–2014: a systematic review. Zhonghua Zhong Liu Za Zhi 38(12):929–941. https://doi.org/10.3760/cma.j.issn.0253-3766.2016.12.010
Liao XZ, Shi JF, Liu JS et al (2018) Medical and non-medical expenditure for breast cancer diagnosis and treatment in China: a multicenter cross-sectional study. Asia Pac J Clin Oncol 14(3):167–178. https://doi.org/10.1111/ajco.12703
Tao W, Zeng Z, Dang H et al (2020) Towards universal health coverage: achievements and challenges of 10 years of healthcare reform in China. BMJ Glob Health 5(3):e2087. https://doi.org/10.1136/bmjgh-2019-002087
The National Healthcare Security Administration (2021) Statistical Bulletin on the Development of National Healthcare Security in 2020. http://www.nhsa.gov.cn/art/2021/6/8/art_7_5232.html. Accessed 4 May 2021.
Zheng A, Duan W, Zhang L et al (2018) How great is current curative expenditure and catastrophic health expenditure among patients with cancer in China? A research based on “System of Health Account 2011”. Cancer Med 7(8):4036–4043. https://doi.org/10.1002/cam4.1590
Wang L, Zhang Y, Shi JF et al (2016) Disease burden of famale breast cancer in China. Zhonghua Liu Xing Bing Xue Za Zhi 37(7):970–976. https://doi.org/10.3760/cma.j.issn.0254-6450.2016.07.013
Longo CJ, Fitch MI, Banfield L et al (2020) Financial toxicity associated with a cancer diagnosis in publicly funded healthcare countries: a systematic review. Support Care Cancer 28(10):4645–4665. https://doi.org/10.1007/s00520-020-05620-9
Arastu A, Patel A, Mohile SG et al (2020) Assessment of financial toxicity among older adults with advanced cancer. JAMA Netw Open 3(12):e2025810. https://doi.org/10.1001/jamanetworkopen.2020.25810
Hazell SZ, Fu W, Hu C et al (2020) Financial toxicity in lung cancer: an assessment of magnitude, perception, and impact on quality of life. Ann Oncol 31(1):96–102. https://doi.org/10.1016/j.annonc.2019.10.006
Beeler WH, Bellile EL, Casper KA et al (2020) Patient-reported financial toxicity and adverse medical consequences in head and neck cancer. Oral Oncol 101:104521. https://doi.org/10.1016/j.oraloncology.2019.104521
Albelda R, Wiemers E, Hahn T et al (2019) Relationship between paid leave, financial burden, and patient-reported outcomes among employed patients who have undergone bone marrow transplantation. Qual Life Res 28(7):1835–1847. https://doi.org/10.1007/s11136-019-02150-8
Casilla-Lennon MM, Choi SK, Deal AM et al (2018) Financial toxicity among patients with bladder cancer: reasons for delay in care and effect on quality of life. J Urol 199(5):1166–1173. https://doi.org/10.1016/j.juro.2017.10.049
Kent EE, Forsythe LP, Yabroff KR et al (2013) Are survivors who report cancer-related financial problems more likely to forgo or delay medical care?. Cancer 119(20):3710–3717. https://doi.org/10.1002/cncr.28262
Offodile AN, Asaad M, Boukovalas S et al (2021) Financial toxicity following surgical treatment for breast cancer: a cross-sectional pilot study. Ann Surg Oncol 28(5):2451–2462. https://doi.org/10.1245/s10434-020-09216-9
Schröder SL, Schumann N, Fink A et al (2020) Coping mechanisms for financial toxicity: a qualitative study of cancer patients’ experiences in Germany. Support Care Cancer 28(3):1131–1139. https://doi.org/10.1007/s00520-019-04915-w
Carrera PM, Kantarjian HM, Blinder VS (2018) The financial burden and distress of patients with cancer: understanding and stepping-up action on the financial toxicity of cancer treatment. CA Cancer J Clin 68(2):153–165. https://doi.org/10.3322/caac.21443
Zafar SY (2016) Financial toxicity of cancer care: it’s time to intervene. J Natl Cancer Inst 108(5). https://doi.org/10.1093/jnci/djv370
de Souza JA, Yap BJ, Hlubocky FJ et al (2014) The development of a financial toxicity patient-reported outcome in cancer: the COST measure. Cancer 120(20):3245–3253. https://doi.org/10.1002/cncr.28814
de Souza JA, Yap BJ, Wroblewski K et al (2017) Measuring financial toxicity as a clinically relevant patient-reported outcome: the validation of the COmprehensive Score for financial Toxicity (COST). Cancer 123(3):476–484. https://doi.org/10.1002/cncr.30369
Allcott N, Dunham L, Levy D et al (2019) Financial burden amongst cancer patients treated with curative intent surgery alone. Am J Surg 218(3):452–456. https://doi.org/10.1016/j.amjsurg.2019.01.033
Mady LJ, Lyu L, Owoc MS et al (2019) Understanding financial toxicity in head and neck cancer survivors. Oral Oncol 95:187–193. https://doi.org/10.1016/j.oraloncology.2019.06.023
Perry LM, Hoerger M, Seibert K et al (2019) Financial strain and physical and emotional quality of life in breast cancer. J Pain Symptom Manage 58(3):454–459. https://doi.org/10.1016/j.jpainsymman.2019.05.011
Jing J, Feng R, Zhang X et al (2020) Financial toxicity and its associated patient and cancer factors among women with breast cancer: a single-center analysis of low-middle income region in China. Breast Cancer Res Treat 181(2):435–443. https://doi.org/10.1007/s10549-020-05632-3
Honda K, Gyawali B, Ando M et al (2019) Prospective survey of financial toxicity measured by the comprehensive score for financial toxicity in Japanese patients with cancer. J Glob Oncol 5:1–8. https://doi.org/10.1200/JGO.19.00003
Huntington SF, Weiss BM, Vogl DT et al (2015) Financial toxicity in insured patients with multiple myeloma: a cross-sectional pilot study. Lancet Haematol 2(10):e408–e416. https://doi.org/10.1016/S2352-3026(15)00151-9
Ripamonti CI, Chiesi F, Di Pede P et al (2020) The validation of the Italian version of the COmprehensive Score for financial Toxicity (COST). Support Care Cancer 28(9):4477–4485. https://doi.org/10.1007/s00520-019-05286-y
Durber K, Halkett GK, Mcmullen M et al (2021) Measuring financial toxicity in Australian cancer patients - validation of the COmprehensive Score for financial Toxicity (FACT COST) measuring financial toxicity in Australian cancer patients. Asia Pac J Clin Oncol. https://doi.org/10.1111/ajco.13508
Hueniken K, Douglas CM, Jethwa AR et al (2020) Measuring financial toxicity incurred after treatment of head and neck cancer: development and validation of the Financial Index of Toxicity questionnaire. Cancer 126(17):4042–4050. https://doi.org/10.1002/cncr.33032
Yu HH, Bi X, Liu YY (2017) Reliability and validity of the Chinese version on Comprehensive Scores for Financial Toxicity based on the patient-reported outcome measures. Zhonghua Liu Xing Bing Xue Za Zhi 38(8):1118–1120
Chan D, Choi KC, Ng M et al (2021) Translation and validation of the Traditional Chinese version of the COmprehensive Score for financial Toxicity-Functional Assessment of Chronic Illness Therapy (Version 2). Health Qual Life Outcomes 19(1):17. https://doi.org/10.3760/cma.j.issn.0254-6450.2017.08.024
Esselen KM, Stack-Dunnbier H, Gompers A, Hacker MR (2021) Crowdsourcing to measure financial toxicity in gynecologic oncology. Gynecol Oncol 161(2):595–600. https://doi.org/10.1016/j.ygyno.2021.01.040
Bouberhan S, Shea M, Kennedy A et al (2019) Financial toxicity in gynecologic oncology. Gynecol Oncol 154(1):8–12. https://doi.org/10.1016/j.ygyno.2019.04.003
Samuel CA, Spencer JC, Rosenstein DL et al (2020) Racial differences in employment and cost-management behaviors in patients with metastatic breast cancer. Breast Cancer Res Treat 179(1):207–215. https://doi.org/10.1007/s10549-019-05449-9
Politi MC, Yen RW, Elwyn G et al (2021) Women who are young, non-white, and with lower socioeconomic status report higher financial toxicity up to 1 year after breast cancer surgery: a mixed-effects regression analysis. Oncologist 26(1):e142–e152. https://doi.org/10.1002/onco.13544
Liang MI, Pisu M, Summerlin SS et al (2020) Extensive financial hardship among gynecologic cancer patients starting a new line of therapy. Gynecol Oncol 156(2):271–277. https://doi.org/10.1016/j.ygyno.2019.11.022
Wan C, Williams CP, Nipp RD et al (2021) Treatment decision making and financial toxicity in women with metastatic breast cancer. Clin Breast Cancer 21(1):37–46. https://doi.org/10.1016/j.clbc.2020.07.002
Dou G, Wang Q, Ying X (2018) Reducing the medical economic burden of health insurance in China: achievements and challenges. Biosci Trends 12(3):215–219. https://doi.org/10.5582/bst.2018.01054
Zhang Y, Wushouer H, Han S et al (2021) The impacts of government reimbursement negotiation on targeted anticancer medication price, volume and spending in China. BMJ Glob Health 6(7):e006196. https://doi.org/10.1136/bmjgh-2021-006196
Zafar SY, Peppercorn JM, Schrag D et al (2013) The financial toxicity of cancer treatment: a pilot study assessing out-of-pocket expenses and the insured cancer patient’s experience. Oncologist 18(4):381–390. https://doi.org/10.1634/theoncologist.2012-0279
Palmer JD, Patel TT, Eldredge-Hindy H et al (2018) Patients undergoing radiation therapy are at risk of financial toxicity: a patient-based prospective survey study. Int J Radiat Oncol Biol Phys 101(2):299–305. https://doi.org/10.1016/j.ijrobp.2018.03.014
Ehlers M, Bjurlin M, Gore J et al (2021) A national cross-sectional survey of financial toxicity among bladder cancer patients. Urol Oncol 39(1):71–76. https://doi.org/10.1016/j.urolonc.2020.09.030
Warner EL, Kent EE, Trevino KM et al (2016) Social well-being among adolescents and young adults with cancer: a systematic review. Cancer 122(7):1029–1037. https://doi.org/10.1002/cncr.29866
Kaddas HK, Pannier ST, Mann K et al (2020) Age-related differences in financial toxicity and unmet resource needs among adolescent and young adult cancer patients. J Adolesc Young Adult Oncol 9(1):105–110. https://doi.org/10.1089/jayao.2019.0051
Murphy PB, Severance S, Savage S et al (2019) Financial toxicity is associated with worse physical and emotional long-term outcomes after traumatic injury. J Trauma Acute Care Surg 87(5):1189–1196. https://doi.org/10.1097/TA.0000000000002409
Gilligan AM, Alberts DS, Roe DJ et al (2018) Death or debt? National estimates of financial toxicity in persons with newly-diagnosed cancer. Am J Med 131(10):1187–1199. https://doi.org/10.1016/j.amjmed.2018.05.020
Jiang Y, Liu C, Li JY et al (2007) Different attitudes of Chinese patients and their families toward truth telling of different stages of cancer. Psychooncology 16(10):928–936. https://doi.org/10.1002/pon.1156
Ni YH, Alræk T (2017) What circumstances lead to non-disclosure of cancer-related information in China? A qualitative study. Support Care Cancer 25(3):811–816. https://doi.org/10.1007/s00520-016-3464-z
Acknowledgements
We would like to thank Editage (www.editage.cn) for English language editing.
Funding
This work was supported by the Chinese Academy of Medical Sciences (Grant numbers 2021-I2M-1–046).
Author information
Authors and Affiliations
Contributions
All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Meicen Liu, Linlin Hu, Jing Sun, and Yuanli Liu. Data interpretations were performed by Meicen Liu, Xueyan Han, and Man Cao. The first draft of the manuscript was written by Meicen Liu and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Corresponding authors
Ethics declarations
Ethics approval
This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Institute of Medical Biology of Chinese Academy of Medical Sciences (IPB-2020–23).
Consent to participate
Informed consent was obtained from all individual participants included in the study.
Competing interests
The authors declare no competing interests.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Implications for practice
An understanding of factors regarding financial toxicity helps oncologists and policy-makers identify at-risk patients and develop targeted interventions. Increased financial toxicity was associated with cumulative coping strategies, and timely support is vital for those patients.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Liu, M., Hu, L., Han, X. et al. Financial toxicity in female patients with breast cancer: a national cross-sectional study in China. Support Care Cancer 30, 8231–8240 (2022). https://doi.org/10.1007/s00520-022-07264-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00520-022-07264-3