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The impact of bilateral salpingo-oophorectomy on sexuality and quality of life in women with breast cancer

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Abstract

Objective

To compare sexual function and quality of life (QoL) in breast cancer survivors with and without a history of bilateral salpingo-oophorectomy (BSO).

Methods

A cross-sectional study of breast cancer survivors treated at a tertiary referral hospital in Western Australia. The Female Sexual Function Index was used to determine rates of female sexual dysfunction (FSD) and hypoactive sexual desire disorder (HSDD). Participants also completed the Relationship Assessment Scale, Menopause-specific quality of life questionnaire and Short Form Health Survey-36.

Results

A total of 427 women were invited to participate: 119 had undergone BSO and 308 were controls with at least one ovary remaining. A total of 172 women participated (overall response rate 40.3%), consisting of 76 women in the BSO group (response rate 63.9%) and 96 women with at least one ovary remaining (response rate 31.2%). There was no difference in FSD between the two groups: 63/76 (82.9%) women who had undergone BSO had FSD compared to 75/96 (78.1%) controls (p = 0.458). No difference in HSDD was observed (p = 0.084) between the BSO group 70/76 (96.0%) and the controls 96/96 (100%). Women who had undergone BSO had lower general health scores compared to the control group (p = 0.034). Both groups had similar energy levels, emotional well-being, pain scores, physical functioning levels and social functioning levels.

Conclusions

In this study, women with prior treatment for breast cancer had high levels of FSD and HSDD, irrespective of whether they had undergone BSO. Both groups reported similar sexual function scores and QoL.

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Acknowledgements

The authors gratefully acknowledge the women who participated in this study.

Funding

This study was funded by St John of God Subiaco Hospital, Perth, Western Australia. Dr. Paige Tucker is a PhD Student at the University of Notre Dame Australia, Fremantle and is supported by a scholarship funded through the St John of God Foundation by a donation from the Kailis Family Foundation, Leederville.

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Authors and Affiliations

  1. St John of God Hospital Bendat Family Comprehensive Cancer Centre, 12 Salvado Rd, Subiaco, WA, 6008, Australia

    Paige E. Tucker, Paul A. Cohen, Stephanie Jeffares & Christobel Saunders

  2. School of Medicine, University of Notre Dame Australia, 21 Henry Street, Fremantle, WA, 6160, Australia

    Paige E. Tucker

  3. Division of Obstetrics and Gynaecology, Faculty of Health and Medical Sciences, University of Western Australia, 35 Stirling Highway, Crawley, WA, 6009, Australia

    Paul A. Cohen

  4. Institute for Health Research, University of Notre Dame Australia, 32 Mouat St, Fremantle, WA, 6160, Australia

    Paul A. Cohen & Max K. Bulsara

  5. Division of Surgery, Faculty of Health and Medical Sciences, University of Western Australia, 35 Stirling Hwy, Crawley, WA, 6009, Australia

    Christobel Saunders

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  1. Paige E. Tucker
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  2. Paul A. Cohen
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Correspondence to Paul A. Cohen.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Tucker, P.E., Cohen, P.A., Bulsara, M.K. et al. The impact of bilateral salpingo-oophorectomy on sexuality and quality of life in women with breast cancer. Support Care Cancer 29, 369–375 (2021). https://doi.org/10.1007/s00520-020-05503-z

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  • DOI: https://doi.org/10.1007/s00520-020-05503-z

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